Testosterone-Induced Modulation of Nitric Oxide-cGMP Signaling Pathway and Androgenesis in the Rat Leydig Cells

Testosterone, acting as a systemic and local factor, is one of the major regulatory molecules that initiate and maintain testicular function. In the present study, different experimental approaches were used to evaluate the role of testosterone in regulation of the nitric oxide (NO)-cGMP pathway in...

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Veröffentlicht in:	Biology of reproduction 2010-09, Vol.83 (3), p.434-442
Hauptverfasser:	ANDRIC, Silvana A, JANJIC, Marija M, STOJKOV, Natasa J, KOSTIC, Tatjana S
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Biological and medical sciences Blotting, Western Cyclic GMP - metabolism Cyclic GMP-Dependent Protein Kinases - metabolism Fundamental and applied biological sciences. Psychology Hypogonadism - metabolism Leydig Cells - drug effects Leydig Cells - metabolism Luteinizing Hormone - blood Male Nitric Oxide - metabolism Nitric Oxide Synthase Type II - metabolism Phosphoric Diester Hydrolases - metabolism Progesterone - blood Radioimmunoassay Rats Rats, Wistar Reverse Transcriptase Polymerase Chain Reaction Signal Transduction - drug effects Testosterone - metabolism Testosterone - pharmacology Up-Regulation Vertebrates: reproduction
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