Interpretation and Inference in Noninferiority Randomized Controlled Trials in Drug Research

Noninferiority (NI) trials in drug research are used for the purpose of demonstrating that a new treatment is not worse than a proven active comparator, thereby indirectly showing that the treatment is effective. This article explains and addresses the complications in the interpretation of NI trial...

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Veröffentlicht in:	Clinical pharmacology and therapeutics 2010-09, Vol.88 (3), p.420-423
Hauptverfasser:	Wangge, G, Klungel, O H, Roes, K C B, Boer, A, Hoes, A W, Knol, M J
Format:	Artikel
Sprache:	eng
Schlagworte:	Data Interpretation, Statistical Humans Pharmaceutical Preparations - administration & dosage Pharmaceutical Preparations - metabolism Randomized Controlled Trials as Topic - methods Research Design Therapeutic Equivalency
Online-Zugang:	Volltext
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