c-erbB-2 and the “triple-state” in early breast carcinomas

Although c-erbB-2 expression is, in general terms, an ominous prognostic indicator in breast carcinomas, there are suggestions that lack of this oncogene, when combined with analogous lack of estrogen (ER negative) and progesterone receptors (PgR negative)—“triple-negative phenotype”, is linked with...

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Veröffentlicht in:	Medical oncology (Northwood, London, England) London, England), 2010-09, Vol.27 (3), p.578-584
Hauptverfasser:	Sivridis, Efthimios, Stamos, Charilaos, Fiska, Aliki, Nikolettos, Nikolaos, Koukourakis, Michael I., Giatromanolaki, Alexandra
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antineoplastic Agents, Hormonal - therapeutic use Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biomarkers, Tumor Breast Neoplasms - chemistry Breast Neoplasms - genetics Breast Neoplasms - mortality Breast Neoplasms - pathology Breast Neoplasms - therapy Carcinoma, Ductal, Breast - chemistry Carcinoma, Ductal, Breast - genetics Carcinoma, Ductal, Breast - mortality Carcinoma, Ductal, Breast - pathology Carcinoma, Ductal, Breast - therapy Chemotherapy, Adjuvant Combined Modality Therapy Female Follow-Up Studies Genes, erbB-2 Hematology Humans Internal Medicine Kaplan-Meier Estimate Lymph Node Excision Mastectomy Medicine Medicine & Public Health Middle Aged Neoplasm Proteins - physiology Oncology Original Paper Pathology Prognosis Receptor, ErbB-2 - physiology Receptors, Estrogen - analysis Receptors, Progesterone - analysis Tamoxifen - therapeutic use
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