Inhibition of hepatic organic anion-transporting polypeptide by RNA interference in sandwich-cultured human hepatocytes: an in vitro model to assess transporter-mediated drug-drug interactions

Organic anion-transporting polypeptides (OATPs), members of the SLCO/SLC21 family, mediate the transport of various endo- and xenobiotics. In human liver, OATP1B1, 1B3, and 2B1 are located at the basolateral membrane of hepatocytes and are involved in hepatic drug uptake and biliary elimination. Cli...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Drug metabolism and disposition 2010-09, Vol.38 (9), p.1612-1622
Hauptverfasser:	Liao, Mingxiang, Raczynski, Arek R, Chen, Michael, Chuang, Bei-Ching, Zhu, Qing, Shipman, Rob, Morrison, Jodi, Lee, David, Lee, Frank W, Balani, Suresh K, Xia, Cindy Q
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromatography, Liquid Drug Interactions Hepatocytes - drug effects Hepatocytes - metabolism Humans Models, Biological Organic Anion Transporters - antagonists & inhibitors Organic Anion Transporters - genetics RNA Interference RNA, Messenger - genetics Tandem Mass Spectrometry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!