Structure and Function of Sphingosine-1-Phosphate Lyase, a Key Enzyme of Sphingolipid Metabolism

Sphingosine-1-phosphate lyase (SPL), a key enzyme of sphingolipid metabolism, catalyzes the irreversible degradation of sphingoid base phosphates. Its main substrate sphingosine-1-phosphate (S1P) acts both extracellularly, by binding G protein-coupled receptors of the lysophospholipid receptor famil...

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Veröffentlicht in:	Structure (London) 2010-08, Vol.18 (8), p.1054-1065
Hauptverfasser:	Bourquin, Florence, Riezman, Howard, Capitani, Guido, Grütter, Markus G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actinobacteria Aldehyde-Lyases - chemistry Aldehyde-Lyases - genetics Aldehyde-Lyases - metabolism Binding Biomedical materials CELLBIO Computational Biology Crystallography Enzymes Humans In vivo testing In vivo tests Lysophospholipids - metabolism Mass Spectrometry Metabolism Models, Chemical Models, Molecular Molecular Structure Mutagenesis Protein Structure, Tertiary PROTEINS Receptors Residues Saccharomyces cerevisiae - enzymology Second Messenger Systems - genetics Sphingolipids - metabolism Sphingosine - analogs & derivatives Sphingosine - metabolism Surgical implants
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