Distinct developmental roles for direct and indirect talin-mediated linkage to actin

Transmembrane adhesion receptors, such as integrins, mediate cell adhesion by interacting with intracellular proteins that connect to the cytoskeleton. Talin, one such linker protein, is essential to connect extracellular matrix-bound integrins to the cytoskeleton. Talin can connect to the cytoskele...

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Veröffentlicht in:	Developmental biology 2010-09, Vol.345 (1), p.64-77
Hauptverfasser:	Franco-Cea, Ari, Ellis, Stephanie J., Fairchild, Michael J., Yuan, Lin, Cheung, Tsz Ying Sylvia, Tanentzapf, Guy
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actins - metabolism Amino Acid Sequence Animals Animals, Genetically Modified Binding Sites - genetics Cell Adhesion Drosophila Drosophila melanogaster - embryology Drosophila melanogaster - genetics Drosophila melanogaster - growth & development Drosophila Proteins - genetics Drosophila Proteins - metabolism Drosophila Proteins - physiology Embryo, Nonmammalian - cytology Embryo, Nonmammalian - embryology Embryo, Nonmammalian - metabolism Gene Expression Regulation, Developmental Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Immunohistochemistry Integrin Integrins - metabolism Microscopy, Confocal Molecular Sequence Data Morphogenesis Muscle Mutation Myotendinous junctions Protein Binding Sequence Homology, Amino Acid Talin Talin - genetics Talin - metabolism Talin - physiology Wings, Animal - embryology Wings, Animal - growth & development Wings, Animal - metabolism
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