Highly Enantioselective Hydrogenative Desymmetrization of Bicyclic Imides Leading to Multiply Functionalized Chiral Cyclic Compounds

Highly enantioselective hydrogenative desymmetrization of bicyclic imides has been developed with chiral Cp*Ru(PN) catalysts. The present hydrogenation directly provides stereochemically well-defined cyclic compounds with excellent enantiomeric exessses, which might otherwise require a detour to rea...

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Veröffentlicht in:	Journal of the American Chemical Society 2010-08, Vol.132 (33), p.11414-11415
Hauptverfasser:	Ito, Masato, Kobayashi, Chika, Himizu, Akio, Ikariya, Takao
Format:	Artikel
Sprache:	eng
Schlagworte:	Bridged Bicyclo Compounds, Heterocyclic - chemical synthesis Bridged Bicyclo Compounds, Heterocyclic - chemistry Hydrogenation Imides - chemical synthesis Imides - chemistry Molecular Structure Stereoisomerism
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creator	Ito, Masato Kobayashi, Chika Himizu, Akio Ikariya, Takao
description	Highly enantioselective hydrogenative desymmetrization of bicyclic imides has been developed with chiral Cp*Ru(PN) catalysts. The present hydrogenation directly provides stereochemically well-defined cyclic compounds with excellent enantiomeric exessses, which might otherwise require a detour to reach.
doi_str_mv	10.1021/ja105048c
format	Article
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subjects	Bridged Bicyclo Compounds, Heterocyclic - chemical synthesis Bridged Bicyclo Compounds, Heterocyclic - chemistry Hydrogenation Imides - chemical synthesis Imides - chemistry Molecular Structure Stereoisomerism
title	Highly Enantioselective Hydrogenative Desymmetrization of Bicyclic Imides Leading to Multiply Functionalized Chiral Cyclic Compounds
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