Stem cell mobilization with G-CSF induces type 17 differentiation and promotes scleroderma

The recent shift to the use of stem cells mobilized by granulocyte colony-stimulating factor (G-CSF) for hematopoietic transplantation has increased chronic graftversus-host disease (GVHD), although the mechanisms of this are unclear. We have found that G-CSF invokes potent type 17 rather than type...

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Veröffentlicht in:	Blood 2010-08, Vol.116 (5), p.819-828
Hauptverfasser:	Hill, Geoffrey R., Olver, Stuart D., Kuns, Rachel D., Varelias, Antiopi, Raffelt, Neil C., Don, Alistair L., Markey, Kate A., Wilson, Yana A., Smyth, Mark J., Iwakura, Yoichiro, Tocker, Joel, Clouston, Andrew D., MacDonald, Kelli P.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Bone Marrow Transplantation - adverse effects CD4-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - metabolism Cell Differentiation - drug effects Crosses, Genetic Cytokines - biosynthesis Female Fibrosis Graft vs Host Disease - etiology Hematologic and hematopoietic diseases Hematopoietic Stem Cell Mobilization - adverse effects Hematopoietic Stem Cell Transplantation - adverse effects Humans Interleukin-17 - metabolism Interleukin-17 - physiology Interleukins - physiology Macrophages - physiology Medical sciences Mice Mice, Inbred BALB C Mice, Inbred DBA Radiation Chimera Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Scleroderma, Localized - etiology Signal Transduction Skin - immunology Skin - pathology T-Lymphocyte Subsets - transplantation Transplantation, Homologous - adverse effects
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