Targeted covalent drugs of the kinase family

In the past decade tremendous progress has been made toward a new class of therapeutics termed ‘targeted covalent drugs’, in which structure-based approaches are employed to create small molecules that inactivate their protein target through targeted covalent attachment to a specific cysteine. In th...

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Veröffentlicht in:	Current opinion in chemical biology 2010-08, Vol.14 (4), p.475-480
Hauptverfasser:	Singh, Juswinder, Petter, Russell C, Kluge, Arthur F
Format:	Artikel
Sprache:	eng
Schlagworte:	Computational Biology Drug Delivery Systems Enzyme Inhibitors - administration & dosage Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Humans Molecular Structure Phosphotransferases - administration & dosage Phosphotransferases - chemistry Phosphotransferases - pharmacology Structure-Activity Relationship
Online-Zugang:	Volltext
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