Bilirubin Exerts Renoprotective Effects in Angiotensin II-Hypertension

Bilirubin is an endogenous antioxidant and is the end product of heme catabolism by heme oxygenase (HO) and biliverdin reductase. Chronic angiotensin II (Ang II) infusion induces renal HO-1 expression that is associated with renoprotective effects, and further induction of renal HO-1 attenuates the...

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Veröffentlicht in:	The American journal of the medical sciences 2010-08, Vol.340 (2), p.144-146
Hauptverfasser:	LeBlanc, Ryan M., Gabriel Navar, L., Botros, Fady T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - antagonists & inhibitors Angiotensin II - pharmacology Animals Arterial hypertension. Arterial hypotension Bilirubin - pharmacology Bilirubin - physiology Biological and medical sciences Blood and lymphatic vessels Blood pressure Blood Pressure - drug effects Blood Pressure - physiology Body Weight - drug effects Body Weight - physiology Cardiology. Vascular system Drinking - drug effects Drinking - physiology Eating - drug effects Eating - physiology General aspects Hypertension - chemically induced Hypertension - drug therapy Hypertension - physiopathology Hypertension - prevention & control Kidney Male Medical sciences Nephrology. Urinary tract diseases Proteinuria Proteinuria - drug therapy Proteinuria - physiopathology Rats Rats, Sprague-Dawley Urinary system involvement in other diseases. Miscellaneous Urinary tract. Prostate gland
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