Bilirubin Exerts Renoprotective Effects in Angiotensin II-Hypertension
Bilirubin is an endogenous antioxidant and is the end product of heme catabolism by heme oxygenase (HO) and biliverdin reductase. Chronic angiotensin II (Ang II) infusion induces renal HO-1 expression that is associated with renoprotective effects, and further induction of renal HO-1 attenuates the...
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| Veröffentlicht in: | The American journal of the medical sciences 2010-08, Vol.340 (2), p.144-146 |
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| creator | LeBlanc, Ryan M. Gabriel Navar, L. Botros, Fady T. |
| description | Bilirubin is an endogenous antioxidant and is the end product of heme catabolism by heme oxygenase (HO) and biliverdin reductase. Chronic angiotensin II (Ang II) infusion induces renal HO-1 expression that is associated with renoprotective effects, and further induction of renal HO-1 attenuates the development of hypertension in this model. To determine the effects of bilirubin on the development of Ang II-induced hypertension and resultant proteinuria, 2 groups of rats were studied: Ang II (n=4) and Ang II+bilirubin (n=4). Rats were infused with Ang II (80 ng/min for 2 weeks), and bilirubin was administered simultaneously in 1 group (3mg/100 g body weight/48 hr, intraperitoneally). Two weeks after onset of Ang II infusion, systolic blood pressure significantly increased from 134 ± 4 to 198 ± 7mm Hg (P < 0.05) in the Ang II group and from 128 ± 8 to 209 ± 9mm Hg (P < 0.05) in the Ang II+bilirubin group. Relative to the Ang II group, treatment with bilirubin did not alter body weight, food intake, water intake or urine output. However, urinary protein excretion was significantly lower in the Ang II+bilirubin group (32.9 ± 9.7mg/d versus 81.4 ± 22.8mg/d, P < 0.05). The authors conclude that exogenous bilirubin exerts renoprotective effects in Ang II-dependent hypertension. |
| doi_str_mv | 10.1097/MAJ.0b013e3181e52de9 |
| format | Article |
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Chronic angiotensin II (Ang II) infusion induces renal HO-1 expression that is associated with renoprotective effects, and further induction of renal HO-1 attenuates the development of hypertension in this model. To determine the effects of bilirubin on the development of Ang II-induced hypertension and resultant proteinuria, 2 groups of rats were studied: Ang II (n=4) and Ang II+bilirubin (n=4). Rats were infused with Ang II (80 ng/min for 2 weeks), and bilirubin was administered simultaneously in 1 group (3mg/100 g body weight/48 hr, intraperitoneally). Two weeks after onset of Ang II infusion, systolic blood pressure significantly increased from 134 ± 4 to 198 ± 7mm Hg (P < 0.05) in the Ang II group and from 128 ± 8 to 209 ± 9mm Hg (P < 0.05) in the Ang II+bilirubin group. Relative to the Ang II group, treatment with bilirubin did not alter body weight, food intake, water intake or urine output. However, urinary protein excretion was significantly lower in the Ang II+bilirubin group (32.9 ± 9.7mg/d versus 81.4 ± 22.8mg/d, P < 0.05). The authors conclude that exogenous bilirubin exerts renoprotective effects in Ang II-dependent hypertension.</description><identifier>ISSN: 0002-9629</identifier><identifier>EISSN: 1538-2990</identifier><identifier>DOI: 10.1097/MAJ.0b013e3181e52de9</identifier><identifier>PMID: 20588179</identifier><identifier>CODEN: AJMSA9</identifier><language>eng</language><publisher>Hagerstown, MD: Elsevier Inc</publisher><subject>Angiotensin II - antagonists & inhibitors ; Angiotensin II - pharmacology ; Animals ; Arterial hypertension. Arterial hypotension ; Bilirubin - pharmacology ; Bilirubin - physiology ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood pressure ; Blood Pressure - drug effects ; Blood Pressure - physiology ; Body Weight - drug effects ; Body Weight - physiology ; Cardiology. Vascular system ; Drinking - drug effects ; Drinking - physiology ; Eating - drug effects ; Eating - physiology ; General aspects ; Hypertension - chemically induced ; Hypertension - drug therapy ; Hypertension - physiopathology ; Hypertension - prevention & control ; Kidney ; Male ; Medical sciences ; Nephrology. Urinary tract diseases ; Proteinuria ; Proteinuria - drug therapy ; Proteinuria - physiopathology ; Rats ; Rats, Sprague-Dawley ; Urinary system involvement in other diseases. Miscellaneous ; Urinary tract. Prostate gland</subject><ispartof>The American journal of the medical sciences, 2010-08, Vol.340 (2), p.144-146</ispartof><rights>2010 Southern Society for Clinical Investigation</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c457t-1c55c3457873333f14a3a80e031f3e32cfd00fb39d776b3832b2e84ab83c74a23</citedby><cites>FETCH-LOGICAL-c457t-1c55c3457873333f14a3a80e031f3e32cfd00fb39d776b3832b2e84ab83c74a23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27926,27927</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23092646$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20588179$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Gabriel Navar, L.</contributor><contributor>Gööz, Monika</contributor><creatorcontrib>LeBlanc, Ryan M.</creatorcontrib><creatorcontrib>Gabriel Navar, L.</creatorcontrib><creatorcontrib>Botros, Fady T.</creatorcontrib><title>Bilirubin Exerts Renoprotective Effects in Angiotensin II-Hypertension</title><title>The American journal of the medical sciences</title><addtitle>Am J Med Sci</addtitle><description>Bilirubin is an endogenous antioxidant and is the end product of heme catabolism by heme oxygenase (HO) and biliverdin reductase. Chronic angiotensin II (Ang II) infusion induces renal HO-1 expression that is associated with renoprotective effects, and further induction of renal HO-1 attenuates the development of hypertension in this model. To determine the effects of bilirubin on the development of Ang II-induced hypertension and resultant proteinuria, 2 groups of rats were studied: Ang II (n=4) and Ang II+bilirubin (n=4). Rats were infused with Ang II (80 ng/min for 2 weeks), and bilirubin was administered simultaneously in 1 group (3mg/100 g body weight/48 hr, intraperitoneally). Two weeks after onset of Ang II infusion, systolic blood pressure significantly increased from 134 ± 4 to 198 ± 7mm Hg (P < 0.05) in the Ang II group and from 128 ± 8 to 209 ± 9mm Hg (P < 0.05) in the Ang II+bilirubin group. Relative to the Ang II group, treatment with bilirubin did not alter body weight, food intake, water intake or urine output. However, urinary protein excretion was significantly lower in the Ang II+bilirubin group (32.9 ± 9.7mg/d versus 81.4 ± 22.8mg/d, P < 0.05). The authors conclude that exogenous bilirubin exerts renoprotective effects in Ang II-dependent hypertension.</description><subject>Angiotensin II - antagonists & inhibitors</subject><subject>Angiotensin II - pharmacology</subject><subject>Animals</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Bilirubin - pharmacology</subject><subject>Bilirubin - physiology</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood pressure</subject><subject>Blood Pressure - drug effects</subject><subject>Blood Pressure - physiology</subject><subject>Body Weight - drug effects</subject><subject>Body Weight - physiology</subject><subject>Cardiology. Vascular system</subject><subject>Drinking - drug effects</subject><subject>Drinking - physiology</subject><subject>Eating - drug effects</subject><subject>Eating - physiology</subject><subject>General aspects</subject><subject>Hypertension - chemically induced</subject><subject>Hypertension - drug therapy</subject><subject>Hypertension - physiopathology</subject><subject>Hypertension - prevention & control</subject><subject>Kidney</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Proteinuria</subject><subject>Proteinuria - drug therapy</subject><subject>Proteinuria - physiopathology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Urinary system involvement in other diseases. Miscellaneous</subject><subject>Urinary tract. Prostate gland</subject><issn>0002-9629</issn><issn>1538-2990</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFKAzEQhoMotlbfQKQX8bR1kuw2yUWoUrWiCKLnkM1OJLLdrcm22Lc30qrgwVzyJ3wzmXyEHFMYUVDi_GFyN4ISKEdOJcWCVah2SJ8WXGZMKdglfQBgmRoz1SMHMb4BUCYp3yc9BoWUVKg-ub70tQ_L0jfD6QeGLg6fsGkXoe3Qdn6Fw6lzKcVhAibNq0_3TUx5Nstu14tU8HVsm0Oy50wd8Wi7D8jL9fT56ja7f7yZXU3uM5sXosuoLQrLU5SCp-VobriRgMCpS_9g1lUAruSqEmJccslZyVDmppTcitwwPiBnm75pwvclxk7PfbRY16bBdhm1yKUqBE0SBiTfkDa0MQZ0ehH83IS1pqC_BOokUP8VmMpOtg8syzlWP0XfxhJwugVMtKZ2wTTWx1-Og2LjfJy4iw2HScfKY9DRemwsVj4kobpq_f-TfAL6FY4A</recordid><startdate>20100801</startdate><enddate>20100801</enddate><creator>LeBlanc, Ryan M.</creator><creator>Gabriel Navar, L.</creator><creator>Botros, Fady T.</creator><general>Elsevier Inc</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100801</creationdate><title>Bilirubin Exerts Renoprotective Effects in Angiotensin II-Hypertension</title><author>LeBlanc, Ryan M. ; Gabriel Navar, L. ; Botros, Fady T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c457t-1c55c3457873333f14a3a80e031f3e32cfd00fb39d776b3832b2e84ab83c74a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Angiotensin II - antagonists & inhibitors</topic><topic>Angiotensin II - pharmacology</topic><topic>Animals</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Bilirubin - pharmacology</topic><topic>Bilirubin - physiology</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood pressure</topic><topic>Blood Pressure - drug effects</topic><topic>Blood Pressure - physiology</topic><topic>Body Weight - drug effects</topic><topic>Body Weight - physiology</topic><topic>Cardiology. Vascular system</topic><topic>Drinking - drug effects</topic><topic>Drinking - physiology</topic><topic>Eating - drug effects</topic><topic>Eating - physiology</topic><topic>General aspects</topic><topic>Hypertension - chemically induced</topic><topic>Hypertension - drug therapy</topic><topic>Hypertension - physiopathology</topic><topic>Hypertension - prevention & control</topic><topic>Kidney</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Proteinuria</topic><topic>Proteinuria - drug therapy</topic><topic>Proteinuria - physiopathology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Urinary system involvement in other diseases. Miscellaneous</topic><topic>Urinary tract. Prostate gland</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LeBlanc, Ryan M.</creatorcontrib><creatorcontrib>Gabriel Navar, L.</creatorcontrib><creatorcontrib>Botros, Fady T.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of the medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LeBlanc, Ryan M.</au><au>Gabriel Navar, L.</au><au>Botros, Fady T.</au><au>Gabriel Navar, L.</au><au>Gööz, Monika</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bilirubin Exerts Renoprotective Effects in Angiotensin II-Hypertension</atitle><jtitle>The American journal of the medical sciences</jtitle><addtitle>Am J Med Sci</addtitle><date>2010-08-01</date><risdate>2010</risdate><volume>340</volume><issue>2</issue><spage>144</spage><epage>146</epage><pages>144-146</pages><issn>0002-9629</issn><eissn>1538-2990</eissn><coden>AJMSA9</coden><abstract>Bilirubin is an endogenous antioxidant and is the end product of heme catabolism by heme oxygenase (HO) and biliverdin reductase. Chronic angiotensin II (Ang II) infusion induces renal HO-1 expression that is associated with renoprotective effects, and further induction of renal HO-1 attenuates the development of hypertension in this model. To determine the effects of bilirubin on the development of Ang II-induced hypertension and resultant proteinuria, 2 groups of rats were studied: Ang II (n=4) and Ang II+bilirubin (n=4). Rats were infused with Ang II (80 ng/min for 2 weeks), and bilirubin was administered simultaneously in 1 group (3mg/100 g body weight/48 hr, intraperitoneally). Two weeks after onset of Ang II infusion, systolic blood pressure significantly increased from 134 ± 4 to 198 ± 7mm Hg (P < 0.05) in the Ang II group and from 128 ± 8 to 209 ± 9mm Hg (P < 0.05) in the Ang II+bilirubin group. Relative to the Ang II group, treatment with bilirubin did not alter body weight, food intake, water intake or urine output. However, urinary protein excretion was significantly lower in the Ang II+bilirubin group (32.9 ± 9.7mg/d versus 81.4 ± 22.8mg/d, P < 0.05). The authors conclude that exogenous bilirubin exerts renoprotective effects in Ang II-dependent hypertension.</abstract><cop>Hagerstown, MD</cop><pub>Elsevier Inc</pub><pmid>20588179</pmid><doi>10.1097/MAJ.0b013e3181e52de9</doi><tpages>3</tpages></addata></record> |
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| subjects | Angiotensin II - antagonists & inhibitors Angiotensin II - pharmacology Animals Arterial hypertension. Arterial hypotension Bilirubin - pharmacology Bilirubin - physiology Biological and medical sciences Blood and lymphatic vessels Blood pressure Blood Pressure - drug effects Blood Pressure - physiology Body Weight - drug effects Body Weight - physiology Cardiology. Vascular system Drinking - drug effects Drinking - physiology Eating - drug effects Eating - physiology General aspects Hypertension - chemically induced Hypertension - drug therapy Hypertension - physiopathology Hypertension - prevention & control Kidney Male Medical sciences Nephrology. Urinary tract diseases Proteinuria Proteinuria - drug therapy Proteinuria - physiopathology Rats Rats, Sprague-Dawley Urinary system involvement in other diseases. Miscellaneous Urinary tract. Prostate gland |
| title | Bilirubin Exerts Renoprotective Effects in Angiotensin II-Hypertension |
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