Synthesis and evaluation of some novel dibenzo[ b, d]furan carboxylic acids as potential anti-diabetic agents

A series of novel dibenzo[ b, d]furan mono-carboxylic acid derivatives were synthesized, characterized and evaluated for their ability to inhibit Protein Tyrosine Phosphatase 1B (PTP1B) in vitro in order to use them as potential anti-diabetic agents. Structure–activity relationship study led to the...

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Veröffentlicht in:	European journal of medicinal chemistry 2010-09, Vol.45 (9), p.3709-3718
Hauptverfasser:	Lakshminarayana, N., Prasad, Y. Rajendra, Gharat, Laxmikant, Thomas, Abraham, Narayanan, Shridhar, Raghuram, A., Srinivasan, C.V., Gopalan, Balasubramanian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-diabetic activity Biological and medical sciences Blood Glucose - metabolism Body Weight - drug effects Carboxylic Acids - chemical synthesis Carboxylic Acids - chemistry Carboxylic Acids - pharmacology Catalytic Domain Cholesterol - blood Dibenzo[ b, d]furan carboxylic acid Drug Discovery Furans - chemistry General and cellular metabolism. Vitamins Hypoglycemic Agents - chemical synthesis Hypoglycemic Agents - chemistry Hypoglycemic Agents - pharmacology Inhibitory Concentration 50 Male Medical sciences Mice Pharmacology. Drug treatments Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors Protein Tyrosine Phosphatase, Non-Receptor Type 1 - chemistry PTP1B inhibition Substrate Specificity Triglycerides - blood
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