An Effective Synthesis of 5,4′-Disubstituted Flavones via a Cesium Enolate Assisted Intramolecular ipso-Substitution Reaction

A variety of 5,4′-disubstituted flavones, which are anticipated to be androgen receptor antagonists to treat diseases mediated by the androgen receptor, were synthesized. It was found that an intramolecular ipso-substitution reaction via cesium enolate using 2-fluoro-6-hydroxyacetophenone and variou...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Chemical & Pharmaceutical Bulletin 2010/08/01, Vol.58(8), pp.1107-1110
Hauptverfasser:	Matsugi, Masato, Takeda, Masaki, Takahashi, Ayano, Tazaki, Takahide, Tamura, Hiroto, Shioiri, Takayuki
Format:	Artikel
Sprache:	eng
Schlagworte:	androgen Androgen Receptor Antagonists - chemical synthesis Androgen Receptor Antagonists - chemistry antagonist Cesium - chemistry flavone Flavones - chemical synthesis Flavones - chemistry Flavones - pharmacology ipso-substitution Molecular Structure Stereoisomerism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!