The effect of early and intensive statin therapy on ventricular premature beat or non-sustained ventricular tachycardia in patients with acute coronary syndrome
Our study's aim was to evaluate the prognostic value of early and intensive lipid-lowering treatment on ventricular premature beat or non-sustained ventricular tachycardia (NSVT) after acute coronary syndrome (STEMI, non-STEMI, and unstable angina pectoris). Some 586 patients with acute coronar...
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| Veröffentlicht in: | Cardiology journal 2010, Vol.17 (4), p.381-385 |
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| creator | He, Xian-zhi Zhou, Sheng-hua Wan, Xin-hong Wang, Hai-yu Zhong, Qing-hua Xue, Jian-fang |
| description | Our study's aim was to evaluate the prognostic value of early and intensive lipid-lowering treatment on ventricular premature beat or non-sustained ventricular tachycardia (NSVT) after acute coronary syndrome (STEMI, non-STEMI, and unstable angina pectoris).
Some 586 patients with acute coronary syndrome were randomly divided into two groups: Group A (with conventional statin therapy, to receive 10 mg/day atorvastatin, n = 289) and Group B (given early and intensive statin therapy, 60 mg immediately and 40 mg/day atorvastatin, n = 297). The frequency of ventricular premature beat and NSVT was recorded via Holter monitoring after hospitalization (24 h and 72 h).
Seventy seven (11.8%) patients had NSVT. When compared to patients with no documented NSVT, patients with NSVT were older and more frequently had myocardial infarction in their history, diabetes mellitus, atrial fibrillation and an ejection fraction < 40%. Ventricular premature beats decreased significantly in the early and aggressive treatment group (24 h, p < 0.01; 72 h, p < 0.001). A significant reduction in NSVT was seen in the early and aggressive treatment group (24 h, p < 0.01; 72 h, p < 0.001). There were no side effects observed in either group.
Early and intensive lipid-lowering treatment can clearly decrease ventricular premature beats and NSVT. |
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Some 586 patients with acute coronary syndrome were randomly divided into two groups: Group A (with conventional statin therapy, to receive 10 mg/day atorvastatin, n = 289) and Group B (given early and intensive statin therapy, 60 mg immediately and 40 mg/day atorvastatin, n = 297). The frequency of ventricular premature beat and NSVT was recorded via Holter monitoring after hospitalization (24 h and 72 h).
Seventy seven (11.8%) patients had NSVT. When compared to patients with no documented NSVT, patients with NSVT were older and more frequently had myocardial infarction in their history, diabetes mellitus, atrial fibrillation and an ejection fraction < 40%. Ventricular premature beats decreased significantly in the early and aggressive treatment group (24 h, p < 0.01; 72 h, p < 0.001). A significant reduction in NSVT was seen in the early and aggressive treatment group (24 h, p < 0.01; 72 h, p < 0.001). There were no side effects observed in either group.
Early and intensive lipid-lowering treatment can clearly decrease ventricular premature beats and NSVT.</description><identifier>ISSN: 1897-5593</identifier><identifier>EISSN: 1897-5593</identifier><identifier>EISSN: 1898-018X</identifier><identifier>PMID: 20690094</identifier><language>eng</language><publisher>Poland: Wydawnictwo Via Medica</publisher><subject>Acute Coronary Syndrome - complications ; Acute Coronary Syndrome - drug therapy ; Acute coronary syndromes ; Aged ; Angina pectoris ; Atorvastatin Calcium ; Cardiac arrhythmia ; Chi-Square Distribution ; China ; Double-Blind Method ; Drug Administration Schedule ; Electrocardiography, Ambulatory ; Female ; Heptanoic Acids - administration & dosage ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage ; Male ; Middle Aged ; Pyrroles - administration & dosage ; Risk Assessment ; Risk Factors ; Statins ; Tachycardia, Ventricular - diagnosis ; Tachycardia, Ventricular - etiology ; Tachycardia, Ventricular - prevention & control ; Time Factors ; Treatment Outcome ; Ventricular Premature Complexes - diagnosis ; Ventricular Premature Complexes - etiology ; Ventricular Premature Complexes - prevention & control</subject><ispartof>Cardiology journal, 2010, Vol.17 (4), p.381-385</ispartof><rights>2010. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,4025</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20690094$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>He, Xian-zhi</creatorcontrib><creatorcontrib>Zhou, Sheng-hua</creatorcontrib><creatorcontrib>Wan, Xin-hong</creatorcontrib><creatorcontrib>Wang, Hai-yu</creatorcontrib><creatorcontrib>Zhong, Qing-hua</creatorcontrib><creatorcontrib>Xue, Jian-fang</creatorcontrib><title>The effect of early and intensive statin therapy on ventricular premature beat or non-sustained ventricular tachycardia in patients with acute coronary syndrome</title><title>Cardiology journal</title><addtitle>Cardiol J</addtitle><description>Our study's aim was to evaluate the prognostic value of early and intensive lipid-lowering treatment on ventricular premature beat or non-sustained ventricular tachycardia (NSVT) after acute coronary syndrome (STEMI, non-STEMI, and unstable angina pectoris).
Some 586 patients with acute coronary syndrome were randomly divided into two groups: Group A (with conventional statin therapy, to receive 10 mg/day atorvastatin, n = 289) and Group B (given early and intensive statin therapy, 60 mg immediately and 40 mg/day atorvastatin, n = 297). The frequency of ventricular premature beat and NSVT was recorded via Holter monitoring after hospitalization (24 h and 72 h).
Seventy seven (11.8%) patients had NSVT. When compared to patients with no documented NSVT, patients with NSVT were older and more frequently had myocardial infarction in their history, diabetes mellitus, atrial fibrillation and an ejection fraction < 40%. Ventricular premature beats decreased significantly in the early and aggressive treatment group (24 h, p < 0.01; 72 h, p < 0.001). A significant reduction in NSVT was seen in the early and aggressive treatment group (24 h, p < 0.01; 72 h, p < 0.001). There were no side effects observed in either group.
Early and intensive lipid-lowering treatment can clearly decrease ventricular premature beats and NSVT.</description><subject>Acute Coronary Syndrome - complications</subject><subject>Acute Coronary Syndrome - drug therapy</subject><subject>Acute coronary syndromes</subject><subject>Aged</subject><subject>Angina pectoris</subject><subject>Atorvastatin Calcium</subject><subject>Cardiac arrhythmia</subject><subject>Chi-Square Distribution</subject><subject>China</subject><subject>Double-Blind Method</subject><subject>Drug Administration Schedule</subject><subject>Electrocardiography, Ambulatory</subject><subject>Female</subject><subject>Heptanoic Acids - administration & dosage</subject><subject>Humans</subject><subject>Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pyrroles - administration & dosage</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Statins</subject><subject>Tachycardia, Ventricular - diagnosis</subject><subject>Tachycardia, Ventricular - etiology</subject><subject>Tachycardia, Ventricular - prevention & control</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Ventricular Premature Complexes - diagnosis</subject><subject>Ventricular Premature Complexes - etiology</subject><subject>Ventricular Premature Complexes - prevention & control</subject><issn>1897-5593</issn><issn>1897-5593</issn><issn>1898-018X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkMFq3DAQhk1I6W62fYUwkENOBtnW2KtjCWlTWOhlczaz8ojVYkuuJKf4bfKoFTSBtqf5Yb75mJmrYlvtVVciqub6r7wpbmK8CNEqxPpjsalzEkLJbfF6PDOwMawTeANMYVyB3ADWJXbRvjDERMk6SGcONK_gHbywS8HqZaQAc-CJ0hIYTkzZEcB5V8YlT1nHwz9sIn1eNYXBUvbDnL25G-GXTWcgvSQG7YN3FFaIqxuCn_hT8cHQGPnzW90Vz18fjw9P5eHHt-8PXw7lXDf7VFY4GJSKTGuwlpVpUCllTli1KLASSNgMuuv2tWwFGdnhoNqqak-dImGE7ppdcf_HOwf_c-GY-slGzeNIjv0S-07ulVRdg5m8-4-8-CW4vFyf7bIWiLLN1O0btZwmHvo52Cnf1b-_vvkN2yODrQ</recordid><startdate>2010</startdate><enddate>2010</enddate><creator>He, Xian-zhi</creator><creator>Zhou, Sheng-hua</creator><creator>Wan, Xin-hong</creator><creator>Wang, Hai-yu</creator><creator>Zhong, Qing-hua</creator><creator>Xue, Jian-fang</creator><general>Wydawnictwo Via Medica</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>2010</creationdate><title>The effect of early and intensive statin therapy on ventricular premature beat or non-sustained ventricular tachycardia in patients with acute coronary syndrome</title><author>He, Xian-zhi ; Zhou, Sheng-hua ; Wan, Xin-hong ; Wang, Hai-yu ; Zhong, Qing-hua ; Xue, Jian-fang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p238t-15df549af6f5241f35999fb516505105a53dc7782460af475d96116b79a0f0c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Acute Coronary Syndrome - complications</topic><topic>Acute Coronary Syndrome - drug therapy</topic><topic>Acute coronary syndromes</topic><topic>Aged</topic><topic>Angina pectoris</topic><topic>Atorvastatin Calcium</topic><topic>Cardiac arrhythmia</topic><topic>Chi-Square Distribution</topic><topic>China</topic><topic>Double-Blind Method</topic><topic>Drug Administration Schedule</topic><topic>Electrocardiography, Ambulatory</topic><topic>Female</topic><topic>Heptanoic Acids - administration & dosage</topic><topic>Humans</topic><topic>Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pyrroles - administration & dosage</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Statins</topic><topic>Tachycardia, Ventricular - diagnosis</topic><topic>Tachycardia, Ventricular - etiology</topic><topic>Tachycardia, Ventricular - prevention & control</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Ventricular Premature Complexes - diagnosis</topic><topic>Ventricular Premature Complexes - etiology</topic><topic>Ventricular Premature Complexes - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>He, Xian-zhi</creatorcontrib><creatorcontrib>Zhou, Sheng-hua</creatorcontrib><creatorcontrib>Wan, Xin-hong</creatorcontrib><creatorcontrib>Wang, Hai-yu</creatorcontrib><creatorcontrib>Zhong, Qing-hua</creatorcontrib><creatorcontrib>Xue, Jian-fang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Cardiology journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>He, Xian-zhi</au><au>Zhou, Sheng-hua</au><au>Wan, Xin-hong</au><au>Wang, Hai-yu</au><au>Zhong, Qing-hua</au><au>Xue, Jian-fang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of early and intensive statin therapy on ventricular premature beat or non-sustained ventricular tachycardia in patients with acute coronary syndrome</atitle><jtitle>Cardiology journal</jtitle><addtitle>Cardiol J</addtitle><date>2010</date><risdate>2010</risdate><volume>17</volume><issue>4</issue><spage>381</spage><epage>385</epage><pages>381-385</pages><issn>1897-5593</issn><eissn>1897-5593</eissn><eissn>1898-018X</eissn><abstract>Our study's aim was to evaluate the prognostic value of early and intensive lipid-lowering treatment on ventricular premature beat or non-sustained ventricular tachycardia (NSVT) after acute coronary syndrome (STEMI, non-STEMI, and unstable angina pectoris).
Some 586 patients with acute coronary syndrome were randomly divided into two groups: Group A (with conventional statin therapy, to receive 10 mg/day atorvastatin, n = 289) and Group B (given early and intensive statin therapy, 60 mg immediately and 40 mg/day atorvastatin, n = 297). The frequency of ventricular premature beat and NSVT was recorded via Holter monitoring after hospitalization (24 h and 72 h).
Seventy seven (11.8%) patients had NSVT. When compared to patients with no documented NSVT, patients with NSVT were older and more frequently had myocardial infarction in their history, diabetes mellitus, atrial fibrillation and an ejection fraction < 40%. Ventricular premature beats decreased significantly in the early and aggressive treatment group (24 h, p < 0.01; 72 h, p < 0.001). A significant reduction in NSVT was seen in the early and aggressive treatment group (24 h, p < 0.01; 72 h, p < 0.001). There were no side effects observed in either group.
Early and intensive lipid-lowering treatment can clearly decrease ventricular premature beats and NSVT.</abstract><cop>Poland</cop><pub>Wydawnictwo Via Medica</pub><pmid>20690094</pmid><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1897-5593 |
| ispartof | Cardiology journal, 2010, Vol.17 (4), p.381-385 |
| issn | 1897-5593 1897-5593 1898-018X |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Acute Coronary Syndrome - complications Acute Coronary Syndrome - drug therapy Acute coronary syndromes Aged Angina pectoris Atorvastatin Calcium Cardiac arrhythmia Chi-Square Distribution China Double-Blind Method Drug Administration Schedule Electrocardiography, Ambulatory Female Heptanoic Acids - administration & dosage Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage Male Middle Aged Pyrroles - administration & dosage Risk Assessment Risk Factors Statins Tachycardia, Ventricular - diagnosis Tachycardia, Ventricular - etiology Tachycardia, Ventricular - prevention & control Time Factors Treatment Outcome Ventricular Premature Complexes - diagnosis Ventricular Premature Complexes - etiology Ventricular Premature Complexes - prevention & control |
| title | The effect of early and intensive statin therapy on ventricular premature beat or non-sustained ventricular tachycardia in patients with acute coronary syndrome |
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