Responses of Blood Lipids and Lipoproteins to Extended-Release Niacin and Exercise in Sedentary Postmenopausal Women
Niacin and exercise positively alter blood lipids and lipoproteins via different mechanisms. However, the effects of niacin combined with exercise on blood lipid and lipoprotein profiles have not been investigated in sedentary postmenopausal women. The current study examined the responses of blood l...
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| Veröffentlicht in: | The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2010-09, Vol.65A (9), p.924-932 |
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| container_title | The journals of gerontology. Series A, Biological sciences and medical sciences |
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| creator | Koh, Yunsuk Ben-Ezra, Vic Biggerstaff, Kyle D. Nichols, David L. |
| description | Niacin and exercise positively alter blood lipids and lipoproteins via different mechanisms. However, the effects of niacin combined with exercise on blood lipid and lipoprotein profiles have not been investigated in sedentary postmenopausal women. The current study examined the responses of blood lipids and lipoproteins to niacin and exercise in 18 sedentary postmenopausal women, who underwent four conditions: no-niacin rest, no-niacin exercise, niacin rest, and niacin exercise. Participants ingested 1,000 mg/day of extended-release niacin for 4 weeks during the niacin condition. As an exercise treatment, participants performed a single bout of exercise on a treadmill at 60% heart rate reserve until 400 kcal were expended. Extended-release niacin without the exercise intervention significantly (p < .001) increased high-density lipoprotein cholesterol and high-density lipoprotein-2 cholesterol by 12.4% and 33.3%, respectively, and decreased the total cholesterol to high-density lipoprotein cholesterol ratio by 14.8%. Thus, 4 weeks of 1,000 mg/day of extended-release niacin can improve the blood lipid and lipoprotein profiles in sedentary postmenopausal women. |
| doi_str_mv | 10.1093/gerona/glq097 |
| format | Article |
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However, the effects of niacin combined with exercise on blood lipid and lipoprotein profiles have not been investigated in sedentary postmenopausal women. The current study examined the responses of blood lipids and lipoproteins to niacin and exercise in 18 sedentary postmenopausal women, who underwent four conditions: no-niacin rest, no-niacin exercise, niacin rest, and niacin exercise. Participants ingested 1,000 mg/day of extended-release niacin for 4 weeks during the niacin condition. As an exercise treatment, participants performed a single bout of exercise on a treadmill at 60% heart rate reserve until 400 kcal were expended. Extended-release niacin without the exercise intervention significantly (p < .001) increased high-density lipoprotein cholesterol and high-density lipoprotein-2 cholesterol by 12.4% and 33.3%, respectively, and decreased the total cholesterol to high-density lipoprotein cholesterol ratio by 14.8%. Thus, 4 weeks of 1,000 mg/day of extended-release niacin can improve the blood lipid and lipoprotein profiles in sedentary postmenopausal women.</description><identifier>ISSN: 1079-5006</identifier><identifier>EISSN: 1758-535X</identifier><identifier>DOI: 10.1093/gerona/glq097</identifier><identifier>PMID: 20530245</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Blood lipids and lipoproteins ; Cholesterol ; Delayed-Action Preparations ; Exercise ; Female ; Humans ; Hypolipidemic Agents - administration & dosage ; Lipids ; Lipids - blood ; Lipoproteins ; Lipoproteins - blood ; Menopause ; Middle Aged ; Niacin - administration & dosage ; Niaspan ; Postmenopausal women ; Postmenopause ; Proteins ; Sedentary Lifestyle ; Vitamin B ; Womens health</subject><ispartof>The journals of gerontology. Series A, Biological sciences and medical sciences, 2010-09, Vol.65A (9), p.924-932</ispartof><rights>The Author 2010. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org. 2010</rights><rights>Copyright Oxford University Press, UK Sep 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c429t-bb625de7f6e0018167d171afdf77184ed54738e5f6ac5bf2410639abc7a61cbb3</citedby><cites>FETCH-LOGICAL-c429t-bb625de7f6e0018167d171afdf77184ed54738e5f6ac5bf2410639abc7a61cbb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1578,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20530245$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koh, Yunsuk</creatorcontrib><creatorcontrib>Ben-Ezra, Vic</creatorcontrib><creatorcontrib>Biggerstaff, Kyle D.</creatorcontrib><creatorcontrib>Nichols, David L.</creatorcontrib><title>Responses of Blood Lipids and Lipoproteins to Extended-Release Niacin and Exercise in Sedentary Postmenopausal Women</title><title>The journals of gerontology. Series A, Biological sciences and medical sciences</title><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><description>Niacin and exercise positively alter blood lipids and lipoproteins via different mechanisms. However, the effects of niacin combined with exercise on blood lipid and lipoprotein profiles have not been investigated in sedentary postmenopausal women. The current study examined the responses of blood lipids and lipoproteins to niacin and exercise in 18 sedentary postmenopausal women, who underwent four conditions: no-niacin rest, no-niacin exercise, niacin rest, and niacin exercise. Participants ingested 1,000 mg/day of extended-release niacin for 4 weeks during the niacin condition. As an exercise treatment, participants performed a single bout of exercise on a treadmill at 60% heart rate reserve until 400 kcal were expended. Extended-release niacin without the exercise intervention significantly (p < .001) increased high-density lipoprotein cholesterol and high-density lipoprotein-2 cholesterol by 12.4% and 33.3%, respectively, and decreased the total cholesterol to high-density lipoprotein cholesterol ratio by 14.8%. Thus, 4 weeks of 1,000 mg/day of extended-release niacin can improve the blood lipid and lipoprotein profiles in sedentary postmenopausal women.</description><subject>Blood lipids and lipoproteins</subject><subject>Cholesterol</subject><subject>Delayed-Action Preparations</subject><subject>Exercise</subject><subject>Female</subject><subject>Humans</subject><subject>Hypolipidemic Agents - administration & dosage</subject><subject>Lipids</subject><subject>Lipids - blood</subject><subject>Lipoproteins</subject><subject>Lipoproteins - blood</subject><subject>Menopause</subject><subject>Middle Aged</subject><subject>Niacin - administration & dosage</subject><subject>Niaspan</subject><subject>Postmenopausal women</subject><subject>Postmenopause</subject><subject>Proteins</subject><subject>Sedentary Lifestyle</subject><subject>Vitamin B</subject><subject>Womens health</subject><issn>1079-5006</issn><issn>1758-535X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1v1DAQxa2Kql9w5IosLvQSasd2nBzZammRVoUWUFe9WE48qVyydmo70vLf4zZLD1zwxfOsn97M-CH0lpKPlDTs7B6Cd_rsfngkjdxDR1SKuhBMrF_lmsimEIRUh-g4xgfydER5gA5LIhgpuThC6Qbi6F2EiH2PF4P3Bq_saE3E2j2Xfgw-gXURJ4-X2wTOgCluYAAdAV9Z3Vn3zC63EDqb37L-DgZc0uE3_uZj2oDzo56iHvCtz-I12u_1EOHN7j5BPz8vf5xfFquvF1_OP62KjpdNKtq2KoUB2VdACK1pJQ2VVPeml5LWHIzgktUg-kp3ou1LTknFGt12Ule0a1t2gj7MvnmFxwliUhsbOxgG7cBPUUleN1zWVGTy_T_kg5-Cy8NliJOSZe8MFTPUBR9jgF6NwW7ykooS9RSGmsNQcxiZf7czndoNmBf67-9n4HQG_DT-12vX28YE2xdYh1-qkkwKdbm-U9fNYs1XF9dqwf4AfsGljg</recordid><startdate>20100901</startdate><enddate>20100901</enddate><creator>Koh, Yunsuk</creator><creator>Ben-Ezra, Vic</creator><creator>Biggerstaff, Kyle D.</creator><creator>Nichols, David L.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20100901</creationdate><title>Responses of Blood Lipids and Lipoproteins to Extended-Release Niacin and Exercise in Sedentary Postmenopausal Women</title><author>Koh, Yunsuk ; Ben-Ezra, Vic ; Biggerstaff, Kyle D. ; Nichols, David L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c429t-bb625de7f6e0018167d171afdf77184ed54738e5f6ac5bf2410639abc7a61cbb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Blood lipids and lipoproteins</topic><topic>Cholesterol</topic><topic>Delayed-Action Preparations</topic><topic>Exercise</topic><topic>Female</topic><topic>Humans</topic><topic>Hypolipidemic Agents - administration & dosage</topic><topic>Lipids</topic><topic>Lipids - blood</topic><topic>Lipoproteins</topic><topic>Lipoproteins - blood</topic><topic>Menopause</topic><topic>Middle Aged</topic><topic>Niacin - administration & dosage</topic><topic>Niaspan</topic><topic>Postmenopausal women</topic><topic>Postmenopause</topic><topic>Proteins</topic><topic>Sedentary Lifestyle</topic><topic>Vitamin B</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koh, Yunsuk</creatorcontrib><creatorcontrib>Ben-Ezra, Vic</creatorcontrib><creatorcontrib>Biggerstaff, Kyle D.</creatorcontrib><creatorcontrib>Nichols, David L.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>The journals of gerontology. 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However, the effects of niacin combined with exercise on blood lipid and lipoprotein profiles have not been investigated in sedentary postmenopausal women. The current study examined the responses of blood lipids and lipoproteins to niacin and exercise in 18 sedentary postmenopausal women, who underwent four conditions: no-niacin rest, no-niacin exercise, niacin rest, and niacin exercise. Participants ingested 1,000 mg/day of extended-release niacin for 4 weeks during the niacin condition. As an exercise treatment, participants performed a single bout of exercise on a treadmill at 60% heart rate reserve until 400 kcal were expended. Extended-release niacin without the exercise intervention significantly (p < .001) increased high-density lipoprotein cholesterol and high-density lipoprotein-2 cholesterol by 12.4% and 33.3%, respectively, and decreased the total cholesterol to high-density lipoprotein cholesterol ratio by 14.8%. 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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Blood lipids and lipoproteins Cholesterol Delayed-Action Preparations Exercise Female Humans Hypolipidemic Agents - administration & dosage Lipids Lipids - blood Lipoproteins Lipoproteins - blood Menopause Middle Aged Niacin - administration & dosage Niaspan Postmenopausal women Postmenopause Proteins Sedentary Lifestyle Vitamin B Womens health |
| title | Responses of Blood Lipids and Lipoproteins to Extended-Release Niacin and Exercise in Sedentary Postmenopausal Women |
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