Tissue Oxygen Tension Profiles Close to Brain Arterioles and Venules in the Rat Cerebral Cortex during the Development of Acute Anemia
Acute anemia (stages 1 and 2) led to decreases in pO 2 at the walls of radial venules (lumen diameter 13.1 ± 0.5 μm) and in the tissues at distances of up to 40 μm from the walls, indicating increased extraction of oxygen from the blood by the smallest microvessels. Further decreases in the blood he...
Gespeichert in:
| Veröffentlicht in: | Neuroscience and behavioral physiology 2010-09, Vol.40 (7), p.723-731 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 731 |
|---|---|
| container_issue | 7 |
| container_start_page | 723 |
| container_title | Neuroscience and behavioral physiology |
| container_volume | 40 |
| creator | Vovenko, E. P. Chuikin, A. E. |
| description | Acute anemia (stages 1 and 2) led to decreases in pO
2
at the walls of radial venules (lumen diameter 13.1 ± 0.5 μm) and in the tissues at distances of up to 40 μm from the walls, indicating increased extraction of oxygen from the blood by the smallest microvessels. Further decreases in the blood hemoglobin concentration (stage 3) did not produce any significant changes in the nature of tissue pO2 profiles close to the walls of these microvessels. In the intercapillary space, tissue pO
2
decreased in proportion to the decrease in the systemic blood hemoglobin concentration, though tissue hypoxia (p
t
O
2
≤ 8–10 mmHg) was seen only in tissue in which the microvessels had inadequate (decreased) blood flow responses. |
| doi_str_mv | 10.1007/s11055-010-9318-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_748945871</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>748945871</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2850-83e93e641f5491124f9d4a5a69ee74b711a695a4e0e951f168196e544f1652343</originalsourceid><addsrcrecordid>eNp1kUFv1DAQhS1ERbcLP4ALsrhwCp1J7MQ-LqEUpEpFaEHcLO_upLhK7MVOqvYP8LvrsKVISJz8pPnesz2PsZcIbxGgOU2IIGUBCIWuUBXwhC1QNlWhtP7-lC0AdFOAFPqYnaR0DdnTKHjGjkuoK1miWrBfa5fSRPzy9u6KPF-TTy54_jmGzvWUeNuHRHwM_F20zvNVHCm6ME-s3_Fv5KdZ58n4g_gXO_KWIm2i7XkbMnvLd1N0_ur3-D3dUB_2A_mRh46vttNIfOVpcPY5O-psn-jFw7lkXz-crduPxcXl-ad2dVFsSyWhUBXpimqBXf4UYik6vRNW2loTNWLTIGYprSAgLbHDWqGuSQqRpSwrUS3Zm0PuPoafE6XRDC5tqe-tpzAl0wilhVQNZvL1P-R1mKLPj8tQpWsQeYdLhgdoG0NKkTqzj26w8c4gmLkic6jI5IrMXJGB7Hn1EDxtBto9Ov50koHyAKT9vDqKf2_-f-o9gu6ayw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>743960406</pqid></control><display><type>article</type><title>Tissue Oxygen Tension Profiles Close to Brain Arterioles and Venules in the Rat Cerebral Cortex during the Development of Acute Anemia</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Vovenko, E. P. ; Chuikin, A. E.</creator><creatorcontrib>Vovenko, E. P. ; Chuikin, A. E.</creatorcontrib><description>Acute anemia (stages 1 and 2) led to decreases in pO
2
at the walls of radial venules (lumen diameter 13.1 ± 0.5 μm) and in the tissues at distances of up to 40 μm from the walls, indicating increased extraction of oxygen from the blood by the smallest microvessels. Further decreases in the blood hemoglobin concentration (stage 3) did not produce any significant changes in the nature of tissue pO2 profiles close to the walls of these microvessels. In the intercapillary space, tissue pO
2
decreased in proportion to the decrease in the systemic blood hemoglobin concentration, though tissue hypoxia (p
t
O
2
≤ 8–10 mmHg) was seen only in tissue in which the microvessels had inadequate (decreased) blood flow responses.</description><identifier>ISSN: 0097-0549</identifier><identifier>EISSN: 1573-899X</identifier><identifier>DOI: 10.1007/s11055-010-9318-0</identifier><identifier>PMID: 20635218</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Acute Disease ; Anemia ; Anemia - physiopathology ; Animals ; Arterioles - physiopathology ; Behavioral Sciences ; Biomedical and Life Sciences ; Biomedicine ; Blood vessels ; Cerebral Cortex - blood supply ; Cerebral Cortex - physiopathology ; Cerebrovascular Circulation - physiology ; Electrodes ; Gases ; Hemoglobin ; Hemoglobins - physiology ; Hypoxia ; Hypoxia - physiopathology ; Male ; Microcirculation - physiology ; Neurobiology ; Neurosciences ; Oxygen - physiology ; Oxygen Consumption - physiology ; Physiology ; Rats ; Rats, Wistar ; Respiration ; Veins & arteries ; Venules - physiopathology</subject><ispartof>Neuroscience and behavioral physiology, 2010-09, Vol.40 (7), p.723-731</ispartof><rights>Springer Science+Business Media, Inc. 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2850-83e93e641f5491124f9d4a5a69ee74b711a695a4e0e951f168196e544f1652343</citedby><cites>FETCH-LOGICAL-c2850-83e93e641f5491124f9d4a5a69ee74b711a695a4e0e951f168196e544f1652343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11055-010-9318-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11055-010-9318-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20635218$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vovenko, E. P.</creatorcontrib><creatorcontrib>Chuikin, A. E.</creatorcontrib><title>Tissue Oxygen Tension Profiles Close to Brain Arterioles and Venules in the Rat Cerebral Cortex during the Development of Acute Anemia</title><title>Neuroscience and behavioral physiology</title><addtitle>Neurosci Behav Physi</addtitle><addtitle>Neurosci Behav Physiol</addtitle><description>Acute anemia (stages 1 and 2) led to decreases in pO
2
at the walls of radial venules (lumen diameter 13.1 ± 0.5 μm) and in the tissues at distances of up to 40 μm from the walls, indicating increased extraction of oxygen from the blood by the smallest microvessels. Further decreases in the blood hemoglobin concentration (stage 3) did not produce any significant changes in the nature of tissue pO2 profiles close to the walls of these microvessels. In the intercapillary space, tissue pO
2
decreased in proportion to the decrease in the systemic blood hemoglobin concentration, though tissue hypoxia (p
t
O
2
≤ 8–10 mmHg) was seen only in tissue in which the microvessels had inadequate (decreased) blood flow responses.</description><subject>Acute Disease</subject><subject>Anemia</subject><subject>Anemia - physiopathology</subject><subject>Animals</subject><subject>Arterioles - physiopathology</subject><subject>Behavioral Sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood vessels</subject><subject>Cerebral Cortex - blood supply</subject><subject>Cerebral Cortex - physiopathology</subject><subject>Cerebrovascular Circulation - physiology</subject><subject>Electrodes</subject><subject>Gases</subject><subject>Hemoglobin</subject><subject>Hemoglobins - physiology</subject><subject>Hypoxia</subject><subject>Hypoxia - physiopathology</subject><subject>Male</subject><subject>Microcirculation - physiology</subject><subject>Neurobiology</subject><subject>Neurosciences</subject><subject>Oxygen - physiology</subject><subject>Oxygen Consumption - physiology</subject><subject>Physiology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Respiration</subject><subject>Veins & arteries</subject><subject>Venules - physiopathology</subject><issn>0097-0549</issn><issn>1573-899X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kUFv1DAQhS1ERbcLP4ALsrhwCp1J7MQ-LqEUpEpFaEHcLO_upLhK7MVOqvYP8LvrsKVISJz8pPnesz2PsZcIbxGgOU2IIGUBCIWuUBXwhC1QNlWhtP7-lC0AdFOAFPqYnaR0DdnTKHjGjkuoK1miWrBfa5fSRPzy9u6KPF-TTy54_jmGzvWUeNuHRHwM_F20zvNVHCm6ME-s3_Fv5KdZ58n4g_gXO_KWIm2i7XkbMnvLd1N0_ur3-D3dUB_2A_mRh46vttNIfOVpcPY5O-psn-jFw7lkXz-crduPxcXl-ad2dVFsSyWhUBXpimqBXf4UYik6vRNW2loTNWLTIGYprSAgLbHDWqGuSQqRpSwrUS3Zm0PuPoafE6XRDC5tqe-tpzAl0wilhVQNZvL1P-R1mKLPj8tQpWsQeYdLhgdoG0NKkTqzj26w8c4gmLkic6jI5IrMXJGB7Hn1EDxtBto9Ov50koHyAKT9vDqKf2_-f-o9gu6ayw</recordid><startdate>201009</startdate><enddate>201009</enddate><creator>Vovenko, E. P.</creator><creator>Chuikin, A. E.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QR</scope><scope>7TK</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>201009</creationdate><title>Tissue Oxygen Tension Profiles Close to Brain Arterioles and Venules in the Rat Cerebral Cortex during the Development of Acute Anemia</title><author>Vovenko, E. P. ; Chuikin, A. E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2850-83e93e641f5491124f9d4a5a69ee74b711a695a4e0e951f168196e544f1652343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Acute Disease</topic><topic>Anemia</topic><topic>Anemia - physiopathology</topic><topic>Animals</topic><topic>Arterioles - physiopathology</topic><topic>Behavioral Sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Blood vessels</topic><topic>Cerebral Cortex - blood supply</topic><topic>Cerebral Cortex - physiopathology</topic><topic>Cerebrovascular Circulation - physiology</topic><topic>Electrodes</topic><topic>Gases</topic><topic>Hemoglobin</topic><topic>Hemoglobins - physiology</topic><topic>Hypoxia</topic><topic>Hypoxia - physiopathology</topic><topic>Male</topic><topic>Microcirculation - physiology</topic><topic>Neurobiology</topic><topic>Neurosciences</topic><topic>Oxygen - physiology</topic><topic>Oxygen Consumption - physiology</topic><topic>Physiology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Respiration</topic><topic>Veins & arteries</topic><topic>Venules - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vovenko, E. P.</creatorcontrib><creatorcontrib>Chuikin, A. E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience and behavioral physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vovenko, E. P.</au><au>Chuikin, A. E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tissue Oxygen Tension Profiles Close to Brain Arterioles and Venules in the Rat Cerebral Cortex during the Development of Acute Anemia</atitle><jtitle>Neuroscience and behavioral physiology</jtitle><stitle>Neurosci Behav Physi</stitle><addtitle>Neurosci Behav Physiol</addtitle><date>2010-09</date><risdate>2010</risdate><volume>40</volume><issue>7</issue><spage>723</spage><epage>731</epage><pages>723-731</pages><issn>0097-0549</issn><eissn>1573-899X</eissn><abstract>Acute anemia (stages 1 and 2) led to decreases in pO
2
at the walls of radial venules (lumen diameter 13.1 ± 0.5 μm) and in the tissues at distances of up to 40 μm from the walls, indicating increased extraction of oxygen from the blood by the smallest microvessels. Further decreases in the blood hemoglobin concentration (stage 3) did not produce any significant changes in the nature of tissue pO2 profiles close to the walls of these microvessels. In the intercapillary space, tissue pO
2
decreased in proportion to the decrease in the systemic blood hemoglobin concentration, though tissue hypoxia (p
t
O
2
≤ 8–10 mmHg) was seen only in tissue in which the microvessels had inadequate (decreased) blood flow responses.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>20635218</pmid><doi>10.1007/s11055-010-9318-0</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0097-0549 |
| ispartof | Neuroscience and behavioral physiology, 2010-09, Vol.40 (7), p.723-731 |
| issn | 0097-0549 1573-899X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_748945871 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Acute Disease Anemia Anemia - physiopathology Animals Arterioles - physiopathology Behavioral Sciences Biomedical and Life Sciences Biomedicine Blood vessels Cerebral Cortex - blood supply Cerebral Cortex - physiopathology Cerebrovascular Circulation - physiology Electrodes Gases Hemoglobin Hemoglobins - physiology Hypoxia Hypoxia - physiopathology Male Microcirculation - physiology Neurobiology Neurosciences Oxygen - physiology Oxygen Consumption - physiology Physiology Rats Rats, Wistar Respiration Veins & arteries Venules - physiopathology |
| title | Tissue Oxygen Tension Profiles Close to Brain Arterioles and Venules in the Rat Cerebral Cortex during the Development of Acute Anemia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-22T14%3A53%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Tissue%20Oxygen%20Tension%20Profiles%20Close%20to%20Brain%20Arterioles%20and%20Venules%20in%20the%20Rat%20Cerebral%20Cortex%20during%20the%20Development%20of%20Acute%20Anemia&rft.jtitle=Neuroscience%20and%20behavioral%20physiology&rft.au=Vovenko,%20E.%20P.&rft.date=2010-09&rft.volume=40&rft.issue=7&rft.spage=723&rft.epage=731&rft.pages=723-731&rft.issn=0097-0549&rft.eissn=1573-899X&rft_id=info:doi/10.1007/s11055-010-9318-0&rft_dat=%3Cproquest_cross%3E748945871%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=743960406&rft_id=info:pmid/20635218&rfr_iscdi=true |