Systemic and cell intrinsic roles of Gqalpha signaling in the regulation of innate immunity, oxidative stress, and longevity in Caenorhabditis elegans

Signal transduction pathways that regulate longevity, immunity, and stress resistance can profoundly affect organismal survival. We show that a signaling module formed by the G protein alpha subunit, Gqalpha, and one of its downstream signal transducer phospholipase C beta (PLCbeta) can differential...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010-08, Vol.107 (31), p.13788-13793
Hauptverfasser:	Kawli, Trupti, Wu, Clay, Tan, Man-Wah
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Caenorhabditis elegans - immunology Caenorhabditis elegans - metabolism Caenorhabditis elegans Proteins - immunology Caenorhabditis elegans Proteins - metabolism Diglycerides - metabolism Gene Expression Regulation GTP-Binding Protein alpha Subunits - genetics GTP-Binding Protein alpha Subunits - immunology GTP-Binding Protein alpha Subunits - metabolism Immunity, Innate Longevity Oxidative Stress Phospholipase C beta - metabolism Signal Transduction
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