Basic Fibroblast Growth Factor Suppresses Radiation-Induced Apoptosis and TP53 Pathway in Rat Small Intestine

The effect of basic fibroblast growth factor (bFGF) was studied in radiation-induced apoptosis in rat jejunal crypt cells. Six-week-old male Wistar rats were administered 4 mg/kg bFGF intraperitoneally 25 h before receiving 8 Gy whole-body X rays. The jejunum was removed for analysis from time 0 to...

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Veröffentlicht in:	Radiation research 2010-07, Vol.174 (1), p.52-61
Hauptverfasser:	Matsuu-Matsuyama, Mutsumi, Nakashima, Masahiro, Shichijo, Kazuko, Okaichi, Kumio, Nakayama, Toshiyuki, Sekine, Ichiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - radiation effects Apoptosis Regulatory Proteins - metabolism Blotting, Western Caspase 3 - metabolism Cell growth Crypts Cyclin-Dependent Kinase Inhibitor p21 - metabolism Epithelial cells Fibroblast Growth Factor 2 - pharmacology Fibroblast growth factors Immunohistochemistry In Situ Nick-End Labeling Intestine, Small - cytology Intestine, Small - drug effects Intestine, Small - metabolism Intestine, Small - radiation effects Irradiation Jejunum Male Proto-Oncogene Proteins - metabolism Radiation dosage Rats Rats, Wistar REGULAR ARTICLES Small intestine Space life sciences Stem cells Tumor Suppressor Protein p53 - metabolism
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