The challenge of annotating protein sequences: The tale of eight domains of unknown function in Pfam

The Pfam database is an important tool in genome annotation, since it provides a collection of curated protein families. However, a subset of these families, known as domains of unknown function (DUFs), remains poorly characterized. We have related sequences from DUF404, DUF407, DUF482, DUF608, DUF8...

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Veröffentlicht in:	Computational biology and chemistry 2010-06, Vol.34 (3), p.210-214
Hauptverfasser:	Goonesekere, Nalin C.W., Shipely, Krysten, O’Connor, Kevin
Format:	Artikel
Sprache:	eng
Schlagworte:	Annotations Biology Catalytic Domain Databases, Protein Domains of unknown function Function prediction Genomes Mathematical analysis Mathematical models Molecular Sequence Annotation - methods Pfam Proteins Sequence Analysis, Protein Sequence homology Sequence Homology, Amino Acid
Online-Zugang:	Volltext
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