Changes in vitamin D levels in patients with systemic lupus erythematosus: Effects on fatigue, disease activity, and damage
Objective To analyze whether changes in serum 25‐hydroxyvitamin D (25[OH]D) levels affect activity, irreversible organ damage, and fatigue in systemic lupus erythematosus (SLE). Methods We performed an observational study of 80 patients with SLE included in a previous cross‐sectional study of 25(OH)...
Gespeichert in:
| Veröffentlicht in: | Arthritis care & research (2010) 2010-08, Vol.62 (8), p.1160-1165 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1165 |
|---|---|
| container_issue | 8 |
| container_start_page | 1160 |
| container_title | Arthritis care & research (2010) |
| container_volume | 62 |
| creator | Ruiz‐Irastorza, Guillermo Gordo, Susana Olivares, Nerea Egurbide, Maria‐Victoria Aguirre, Ciriaco |
| description | Objective
To analyze whether changes in serum 25‐hydroxyvitamin D (25[OH]D) levels affect activity, irreversible organ damage, and fatigue in systemic lupus erythematosus (SLE).
Methods
We performed an observational study of 80 patients with SLE included in a previous cross‐sectional study of 25(OH)D, reassessed 2 years later. Oral vitamin D3 was recommended in those with low baseline 25(OH)D levels. The relationship between changes in 25(OH)D levels from baseline and changes in fatigue (measured by a 0–10 visual analog scale [VAS]), SLE activity (measured by the Systemic Lupus Erythematosus Disease Activity Index [SLEDAI]), and irreversible organ damage (measured by the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index [SDI]) were analyzed.
Results
Sixty patients took vitamin D3. Mean 25(OH)D levels increased among all treated patients (P = 0.044), in those with baseline vitamin D levels |
| doi_str_mv | 10.1002/acr.20186 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_748940893</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>748940893</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3246-7463bbbf7e0b6fc06d17f6de0a39efd879c36b4bca66fbce2ffa18923f3d954d3</originalsourceid><addsrcrecordid>eNp1kE1LAzEQhoMoKtWDf0ByE8HWbLLNZr1J_QRBEAVvSzaZtJH9qDvZyuKfN7bqzbm8w_DMc3gJOUrYJGGMn2vTTThLlNwi-zyZJuNUTtX2356-7pFDxDcWR3ClRL5L9jjjYsqZ2iefs4Vu5oDUN3Tlg65jXtEKVlCtb0sdPDQB6YcPC4oDBqi9oVW_7JFCN4QF1Dq02OMFvXYOTETbhrr4Nu_hjFqPoBGoNsFH_3BGdWOp1bWewwHZcbpCOPzJEXm5uX6e3Y0fHm_vZ5cPYyN4KsdZKkVZli4DVkpnmLRJ5qQFpkUOzqosN0KWaWm0lK40wJ3Ticq5cMLm09SKETnZeJdd-94DhqL2aKCqdANtj0WWqjxlKheRPN2QpmsRO3DFsvO17oYiYcV320Vsu1i3HdnjH2tf1mD_yN9uI3C-AT58BcP_puJy9rRRfgGi7Ytr</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>748940893</pqid></control><display><type>article</type><title>Changes in vitamin D levels in patients with systemic lupus erythematosus: Effects on fatigue, disease activity, and damage</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Ruiz‐Irastorza, Guillermo ; Gordo, Susana ; Olivares, Nerea ; Egurbide, Maria‐Victoria ; Aguirre, Ciriaco</creator><creatorcontrib>Ruiz‐Irastorza, Guillermo ; Gordo, Susana ; Olivares, Nerea ; Egurbide, Maria‐Victoria ; Aguirre, Ciriaco</creatorcontrib><description><![CDATA[Objective
To analyze whether changes in serum 25‐hydroxyvitamin D (25[OH]D) levels affect activity, irreversible organ damage, and fatigue in systemic lupus erythematosus (SLE).
Methods
We performed an observational study of 80 patients with SLE included in a previous cross‐sectional study of 25(OH)D, reassessed 2 years later. Oral vitamin D3 was recommended in those with low baseline 25(OH)D levels. The relationship between changes in 25(OH)D levels from baseline and changes in fatigue (measured by a 0–10 visual analog scale [VAS]), SLE activity (measured by the Systemic Lupus Erythematosus Disease Activity Index [SLEDAI]), and irreversible organ damage (measured by the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index [SDI]) were analyzed.
Results
Sixty patients took vitamin D3. Mean 25(OH)D levels increased among all treated patients (P = 0.044), in those with baseline vitamin D levels <30 ng/ml (P < 0.001), and in those with baseline vitamin D levels <10 ng/ml (P = 0.005). Fifty‐seven patients (71%) still had 25(OH)D levels <30 ng/ml and 5 (6%) had 25(OH)D levels <10 ng/ml. Inverse significant correlations between 25(OH)D levels and the VAS (P = 0.001) and between changes in 25(OH)D levels and changes in the VAS in patients with baseline 25(OH)D levels <30 ng/ml (P = 0.017) were found. No significant correlations were seen between the variation of the SLEDAI or SDI values and the variation in 25(OH)D levels (P = 0.87 and P = 0.63, respectively).
Conclusion
Increasing 25(OH)D levels may have a beneficial effect on fatigue. Our results do not support any effects of increasing 25(OH)D levels on SLE severity, although they are limited by the insufficient 25(OH)D response to the recommended regimen of oral vitamin D3 replacement.]]></description><identifier>ISSN: 2151-464X</identifier><identifier>EISSN: 2151-4658</identifier><identifier>DOI: 10.1002/acr.20186</identifier><identifier>PMID: 20235208</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Adult ; Cholecalciferol ; Cross-Sectional Studies ; Fatigue ; Female ; Humans ; Lupus Erythematosus, Systemic - blood ; Male ; Middle Aged ; Treatment Outcome ; Vitamin D - analogs & derivatives</subject><ispartof>Arthritis care & research (2010), 2010-08, Vol.62 (8), p.1160-1165</ispartof><rights>Copyright © 2010 by the American College of Rheumatology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3246-7463bbbf7e0b6fc06d17f6de0a39efd879c36b4bca66fbce2ffa18923f3d954d3</citedby><cites>FETCH-LOGICAL-c3246-7463bbbf7e0b6fc06d17f6de0a39efd879c36b4bca66fbce2ffa18923f3d954d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Facr.20186$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Facr.20186$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20235208$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ruiz‐Irastorza, Guillermo</creatorcontrib><creatorcontrib>Gordo, Susana</creatorcontrib><creatorcontrib>Olivares, Nerea</creatorcontrib><creatorcontrib>Egurbide, Maria‐Victoria</creatorcontrib><creatorcontrib>Aguirre, Ciriaco</creatorcontrib><title>Changes in vitamin D levels in patients with systemic lupus erythematosus: Effects on fatigue, disease activity, and damage</title><title>Arthritis care & research (2010)</title><addtitle>Arthritis Care Res (Hoboken)</addtitle><description><![CDATA[Objective
To analyze whether changes in serum 25‐hydroxyvitamin D (25[OH]D) levels affect activity, irreversible organ damage, and fatigue in systemic lupus erythematosus (SLE).
Methods
We performed an observational study of 80 patients with SLE included in a previous cross‐sectional study of 25(OH)D, reassessed 2 years later. Oral vitamin D3 was recommended in those with low baseline 25(OH)D levels. The relationship between changes in 25(OH)D levels from baseline and changes in fatigue (measured by a 0–10 visual analog scale [VAS]), SLE activity (measured by the Systemic Lupus Erythematosus Disease Activity Index [SLEDAI]), and irreversible organ damage (measured by the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index [SDI]) were analyzed.
Results
Sixty patients took vitamin D3. Mean 25(OH)D levels increased among all treated patients (P = 0.044), in those with baseline vitamin D levels <30 ng/ml (P < 0.001), and in those with baseline vitamin D levels <10 ng/ml (P = 0.005). Fifty‐seven patients (71%) still had 25(OH)D levels <30 ng/ml and 5 (6%) had 25(OH)D levels <10 ng/ml. Inverse significant correlations between 25(OH)D levels and the VAS (P = 0.001) and between changes in 25(OH)D levels and changes in the VAS in patients with baseline 25(OH)D levels <30 ng/ml (P = 0.017) were found. No significant correlations were seen between the variation of the SLEDAI or SDI values and the variation in 25(OH)D levels (P = 0.87 and P = 0.63, respectively).
Conclusion
Increasing 25(OH)D levels may have a beneficial effect on fatigue. Our results do not support any effects of increasing 25(OH)D levels on SLE severity, although they are limited by the insufficient 25(OH)D response to the recommended regimen of oral vitamin D3 replacement.]]></description><subject>Adult</subject><subject>Cholecalciferol</subject><subject>Cross-Sectional Studies</subject><subject>Fatigue</subject><subject>Female</subject><subject>Humans</subject><subject>Lupus Erythematosus, Systemic - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Treatment Outcome</subject><subject>Vitamin D - analogs & derivatives</subject><issn>2151-464X</issn><issn>2151-4658</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1LAzEQhoMoKtWDf0ByE8HWbLLNZr1J_QRBEAVvSzaZtJH9qDvZyuKfN7bqzbm8w_DMc3gJOUrYJGGMn2vTTThLlNwi-zyZJuNUTtX2356-7pFDxDcWR3ClRL5L9jjjYsqZ2iefs4Vu5oDUN3Tlg65jXtEKVlCtb0sdPDQB6YcPC4oDBqi9oVW_7JFCN4QF1Dq02OMFvXYOTETbhrr4Nu_hjFqPoBGoNsFH_3BGdWOp1bWewwHZcbpCOPzJEXm5uX6e3Y0fHm_vZ5cPYyN4KsdZKkVZli4DVkpnmLRJ5qQFpkUOzqosN0KWaWm0lK40wJ3Ticq5cMLm09SKETnZeJdd-94DhqL2aKCqdANtj0WWqjxlKheRPN2QpmsRO3DFsvO17oYiYcV320Vsu1i3HdnjH2tf1mD_yN9uI3C-AT58BcP_puJy9rRRfgGi7Ytr</recordid><startdate>201008</startdate><enddate>201008</enddate><creator>Ruiz‐Irastorza, Guillermo</creator><creator>Gordo, Susana</creator><creator>Olivares, Nerea</creator><creator>Egurbide, Maria‐Victoria</creator><creator>Aguirre, Ciriaco</creator><general>John Wiley & Sons, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201008</creationdate><title>Changes in vitamin D levels in patients with systemic lupus erythematosus: Effects on fatigue, disease activity, and damage</title><author>Ruiz‐Irastorza, Guillermo ; Gordo, Susana ; Olivares, Nerea ; Egurbide, Maria‐Victoria ; Aguirre, Ciriaco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3246-7463bbbf7e0b6fc06d17f6de0a39efd879c36b4bca66fbce2ffa18923f3d954d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Cholecalciferol</topic><topic>Cross-Sectional Studies</topic><topic>Fatigue</topic><topic>Female</topic><topic>Humans</topic><topic>Lupus Erythematosus, Systemic - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Treatment Outcome</topic><topic>Vitamin D - analogs & derivatives</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ruiz‐Irastorza, Guillermo</creatorcontrib><creatorcontrib>Gordo, Susana</creatorcontrib><creatorcontrib>Olivares, Nerea</creatorcontrib><creatorcontrib>Egurbide, Maria‐Victoria</creatorcontrib><creatorcontrib>Aguirre, Ciriaco</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Arthritis care & research (2010)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ruiz‐Irastorza, Guillermo</au><au>Gordo, Susana</au><au>Olivares, Nerea</au><au>Egurbide, Maria‐Victoria</au><au>Aguirre, Ciriaco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in vitamin D levels in patients with systemic lupus erythematosus: Effects on fatigue, disease activity, and damage</atitle><jtitle>Arthritis care & research (2010)</jtitle><addtitle>Arthritis Care Res (Hoboken)</addtitle><date>2010-08</date><risdate>2010</risdate><volume>62</volume><issue>8</issue><spage>1160</spage><epage>1165</epage><pages>1160-1165</pages><issn>2151-464X</issn><eissn>2151-4658</eissn><abstract><![CDATA[Objective
To analyze whether changes in serum 25‐hydroxyvitamin D (25[OH]D) levels affect activity, irreversible organ damage, and fatigue in systemic lupus erythematosus (SLE).
Methods
We performed an observational study of 80 patients with SLE included in a previous cross‐sectional study of 25(OH)D, reassessed 2 years later. Oral vitamin D3 was recommended in those with low baseline 25(OH)D levels. The relationship between changes in 25(OH)D levels from baseline and changes in fatigue (measured by a 0–10 visual analog scale [VAS]), SLE activity (measured by the Systemic Lupus Erythematosus Disease Activity Index [SLEDAI]), and irreversible organ damage (measured by the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index [SDI]) were analyzed.
Results
Sixty patients took vitamin D3. Mean 25(OH)D levels increased among all treated patients (P = 0.044), in those with baseline vitamin D levels <30 ng/ml (P < 0.001), and in those with baseline vitamin D levels <10 ng/ml (P = 0.005). Fifty‐seven patients (71%) still had 25(OH)D levels <30 ng/ml and 5 (6%) had 25(OH)D levels <10 ng/ml. Inverse significant correlations between 25(OH)D levels and the VAS (P = 0.001) and between changes in 25(OH)D levels and changes in the VAS in patients with baseline 25(OH)D levels <30 ng/ml (P = 0.017) were found. No significant correlations were seen between the variation of the SLEDAI or SDI values and the variation in 25(OH)D levels (P = 0.87 and P = 0.63, respectively).
Conclusion
Increasing 25(OH)D levels may have a beneficial effect on fatigue. Our results do not support any effects of increasing 25(OH)D levels on SLE severity, although they are limited by the insufficient 25(OH)D response to the recommended regimen of oral vitamin D3 replacement.]]></abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>20235208</pmid><doi>10.1002/acr.20186</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2151-464X |
| ispartof | Arthritis care & research (2010), 2010-08, Vol.62 (8), p.1160-1165 |
| issn | 2151-464X 2151-4658 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_748940893 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Cholecalciferol Cross-Sectional Studies Fatigue Female Humans Lupus Erythematosus, Systemic - blood Male Middle Aged Treatment Outcome Vitamin D - analogs & derivatives |
| title | Changes in vitamin D levels in patients with systemic lupus erythematosus: Effects on fatigue, disease activity, and damage |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T21%3A41%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Changes%20in%20vitamin%20D%20levels%20in%20patients%20with%20systemic%20lupus%20erythematosus:%20Effects%20on%20fatigue,%20disease%20activity,%20and%20damage&rft.jtitle=Arthritis%20care%20&%20research%20(2010)&rft.au=Ruiz%E2%80%90Irastorza,%20Guillermo&rft.date=2010-08&rft.volume=62&rft.issue=8&rft.spage=1160&rft.epage=1165&rft.pages=1160-1165&rft.issn=2151-464X&rft.eissn=2151-4658&rft_id=info:doi/10.1002/acr.20186&rft_dat=%3Cproquest_cross%3E748940893%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=748940893&rft_id=info:pmid/20235208&rfr_iscdi=true |