FAD286, an aldosterone synthase inhibitor, reduced atherosclerosis and inflammation in apolipoprotein E-deficient mice

Aldosterone is known to be involved in atherosclerosis and cardiovascular disease and blockade of its receptor was shown to improve cardiovascular function. It was, therefore, hypothesized that inhibition of aldosterone synthesis would also reduce atherosclerosis development. To test this hypothesis...

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Veröffentlicht in:Journal of hypertension 2010-09, Vol.28 (9), p.1900-1907
Hauptverfasser: GAMLIEL-LAZAROVICH, Aviva, GANTMAN, Anna, COLEMAN, Raymond, JENG, Arco Y, KAPLAN, Marielle, KEIDAR, Shlomo
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Sprache:eng
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