Noninvasive Remote-Controlled Release of Drug Molecules in Vitro Using Magnetic Actuation of Mechanized Nanoparticles
Mesoporous silica nanoparticles are useful nanomaterials that have demonstrated the ability to contain and release cargos with mediation by gatekeepers. Magnetic nanocrystals have the ability to exhibit hyperthermic effects when placed in an oscillating magnetic field. In a system combining these tw...
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| Veröffentlicht in: | Journal of the American Chemical Society 2010-08, Vol.132 (31), p.10623-10625 |
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| container_issue | 31 |
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| container_title | Journal of the American Chemical Society |
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| creator | Thomas, Courtney R Ferris, Daniel P Lee, Jae-Hyun Choi, Eunjoo Cho, Mi Hyeon Kim, Eun Sook Stoddart, J. Fraser Shin, Jeon-Soo Cheon, Jinwoo Zink, Jeffrey I |
| description | Mesoporous silica nanoparticles are useful nanomaterials that have demonstrated the ability to contain and release cargos with mediation by gatekeepers. Magnetic nanocrystals have the ability to exhibit hyperthermic effects when placed in an oscillating magnetic field. In a system combining these two materials and a thermally sensitive gatekeeper, a unique drug delivery system can be produced. A novel material that incorporates zinc-doped iron oxide nanocrystals within a mesoporous silica framework that has been surface-modified with pseudorotaxanes is described. Upon application of an AC magnetic field, the nanocrystals generate local internal heating, causing the molecular machines to disassemble and allowing the cargos (drugs) to be released. When breast cancer cells (MDA-MB-231) were treated with doxorubicin-loaded particles and exposed to an AC field, cell death occurred. This material promises to be a noninvasive, externally controlled drug delivery system with cancer-killing properties. |
| doi_str_mv | 10.1021/ja1022267 |
| format | Article |
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Upon application of an AC magnetic field, the nanocrystals generate local internal heating, causing the molecular machines to disassemble and allowing the cargos (drugs) to be released. When breast cancer cells (MDA-MB-231) were treated with doxorubicin-loaded particles and exposed to an AC field, cell death occurred. 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Fraser</creatorcontrib><creatorcontrib>Shin, Jeon-Soo</creatorcontrib><creatorcontrib>Cheon, Jinwoo</creatorcontrib><creatorcontrib>Zink, Jeffrey I</creatorcontrib><title>Noninvasive Remote-Controlled Release of Drug Molecules in Vitro Using Magnetic Actuation of Mechanized Nanoparticles</title><title>Journal of the American Chemical Society</title><addtitle>J. Am. Chem. Soc</addtitle><description>Mesoporous silica nanoparticles are useful nanomaterials that have demonstrated the ability to contain and release cargos with mediation by gatekeepers. Magnetic nanocrystals have the ability to exhibit hyperthermic effects when placed in an oscillating magnetic field. In a system combining these two materials and a thermally sensitive gatekeeper, a unique drug delivery system can be produced. A novel material that incorporates zinc-doped iron oxide nanocrystals within a mesoporous silica framework that has been surface-modified with pseudorotaxanes is described. Upon application of an AC magnetic field, the nanocrystals generate local internal heating, causing the molecular machines to disassemble and allowing the cargos (drugs) to be released. When breast cancer cells (MDA-MB-231) were treated with doxorubicin-loaded particles and exposed to an AC field, cell death occurred. 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| subjects | Antineoplastic Agents - chemistry Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacokinetics Cell Death - drug effects Cell Line, Tumor Doxorubicin - chemistry Doxorubicin - metabolism Doxorubicin - pharmacokinetics Drug Delivery Systems Humans Magnetics Nanoparticles - chemistry Particle Size Porosity Silicon Dioxide - chemistry Surface Properties |
| title | Noninvasive Remote-Controlled Release of Drug Molecules in Vitro Using Magnetic Actuation of Mechanized Nanoparticles |
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