Pharmacokinetics and bioequivalence evaluation of two losartan potassium 50-mg tablets: A single-dose, randomized-sequence, open-label, two-way crossover study in healthy Chinese male volunteers

Abstract Background: Losartan is a nonpeptide angiotensin II receptor antagonist used as an antihypertensive agent. The relative bioavailability of a newly developed tablet compared with an established branded formulation has not been reported in a Chinese population. Objective: To meet the requirem...

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Veröffentlicht in:	Clinical therapeutics 2010-07, Vol.32 (7), p.1387-1395
Hauptverfasser:	Jia, Jing-Ying, MS, Zhang, Meng-Qi, MS, Liu, Yan-Mei, MD, Liu, Yun, MD, Liu, Gang-Yi, MS, Li, Shui-Jun, PhD, Lu, Chuan, BPharm, Weng, Li-ping, MS, Qi, Yu-Lin, MS, Yu, Chen, MS
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Angiotensin II Type 1 Receptor Blockers - administration & dosage Angiotensin II Type 1 Receptor Blockers - adverse effects Angiotensin II Type 1 Receptor Blockers - pharmacokinetics Area Under Curve Asian Continental Ancestry Group bioequivalence Biological and medical sciences Biological Availability China Chinese Cross-Over Studies Drugs, Generic - administration & dosage Drugs, Generic - adverse effects Drugs, Generic - pharmacokinetics EXP3174 Humans Internal Medicine LC-MS/MS losartan Losartan - administration & dosage Losartan - adverse effects Losartan - pharmacokinetics Male Medical Education Medical sciences pharmacokinetics Pharmacology. Drug treatments Tablets Therapeutic Equivalency Young Adult
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