Effect of Growth Hormone upon the RNA Polymerase and Deoxythymidine Kinase Activities of Regenerating Liver in Hypophysectomized Rats
Regenerating rat liver showed markedly increased nuclear, nucleolar and chromatin RNA polymerase [EC 2.7.7.6] activities 6 hr after partial hepatectomy. Deoxy-thymidine kinase [EC 2.7.1.21] activity began to increase 20–24 hr after partial hepatectomy. However, after hypophysectomy and partial hepat...
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| Veröffentlicht in: | Journal of biochemistry (Tokyo) 1971-06, Vol.69 (6), p.1091-1095 |
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| container_end_page | 1095 |
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| container_issue | 6 |
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| container_title | Journal of biochemistry (Tokyo) |
| container_volume | 69 |
| creator | AKAMATSU, Nobu KAMIYA, Tsutomu MAEDA, Hideyasu R. ENDO, Noriko FUKUI, Noriko MIURA, Yoshiaki |
| description | Regenerating rat liver showed markedly increased nuclear, nucleolar and chromatin RNA polymerase [EC 2.7.7.6] activities 6 hr after partial hepatectomy. Deoxy-thymidine kinase [EC 2.7.1.21] activity began to increase 20–24 hr after partial hepatectomy. However, after hypophysectomy and partial hepatectomy these enzymeactivities did not show corresponding increases. Treatment of hypophysectomized rats with growth hormone before partial hepatectomy resulted in increases in the RNA polymerase and deoxythymidine kinase activities 6hr and 20 hr, respectively, after partial hepatectomy. These results suggest that the growth hormone may be involved in initiation of liver regeneration. |
| doi_str_mv | 10.1093/oxfordjournals.jbchem.a129562 |
| format | Article |
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Deoxy-thymidine kinase [EC 2.7.1.21] activity began to increase 20–24 hr after partial hepatectomy. However, after hypophysectomy and partial hepatectomy these enzymeactivities did not show corresponding increases. Treatment of hypophysectomized rats with growth hormone before partial hepatectomy resulted in increases in the RNA polymerase and deoxythymidine kinase activities 6hr and 20 hr, respectively, after partial hepatectomy. These results suggest that the growth hormone may be involved in initiation of liver regeneration.</description><identifier>ISSN: 0021-924X</identifier><identifier>EISSN: 1756-2651</identifier><identifier>DOI: 10.1093/oxfordjournals.jbchem.a129562</identifier><identifier>PMID: 5091940</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Animals ; Carbon Isotopes ; Cell Nucleolus - enzymology ; Cell Nucleus - enzymology ; Growth Hormone - pharmacology ; Hepatectomy ; Hypophysectomy ; Liver - enzymology ; Liver Regeneration ; Male ; Rats ; RNA Nucleotidyltransferases - metabolism ; Stimulation, Chemical ; Thymidine Kinase - metabolism ; Time Factors</subject><ispartof>Journal of biochemistry (Tokyo), 1971-06, Vol.69 (6), p.1091-1095</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-2109fc151c35b0d44f06c1ca49b81ed7b41a7e26782cf480c3d5d08106d7559e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5091940$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>AKAMATSU, Nobu</creatorcontrib><creatorcontrib>KAMIYA, Tsutomu</creatorcontrib><creatorcontrib>MAEDA, Hideyasu R.</creatorcontrib><creatorcontrib>ENDO, Noriko</creatorcontrib><creatorcontrib>FUKUI, Noriko</creatorcontrib><creatorcontrib>MIURA, Yoshiaki</creatorcontrib><title>Effect of Growth Hormone upon the RNA Polymerase and Deoxythymidine Kinase Activities of Regenerating Liver in Hypophysectomized Rats</title><title>Journal of biochemistry (Tokyo)</title><addtitle>J Biochem</addtitle><description>Regenerating rat liver showed markedly increased nuclear, nucleolar and chromatin RNA polymerase [EC 2.7.7.6] activities 6 hr after partial hepatectomy. Deoxy-thymidine kinase [EC 2.7.1.21] activity began to increase 20–24 hr after partial hepatectomy. However, after hypophysectomy and partial hepatectomy these enzymeactivities did not show corresponding increases. Treatment of hypophysectomized rats with growth hormone before partial hepatectomy resulted in increases in the RNA polymerase and deoxythymidine kinase activities 6hr and 20 hr, respectively, after partial hepatectomy. These results suggest that the growth hormone may be involved in initiation of liver regeneration.</description><subject>Animals</subject><subject>Carbon Isotopes</subject><subject>Cell Nucleolus - enzymology</subject><subject>Cell Nucleus - enzymology</subject><subject>Growth Hormone - pharmacology</subject><subject>Hepatectomy</subject><subject>Hypophysectomy</subject><subject>Liver - enzymology</subject><subject>Liver Regeneration</subject><subject>Male</subject><subject>Rats</subject><subject>RNA Nucleotidyltransferases - metabolism</subject><subject>Stimulation, Chemical</subject><subject>Thymidine Kinase - metabolism</subject><subject>Time Factors</subject><issn>0021-924X</issn><issn>1756-2651</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1971</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUU2P0zAQtRBoKYWfgOQL3NK14zhODhzKfrSIio8KUMXFcuzJ1qWJg-3sNtz536RqtRKH0Wj05r3RvIfQG0pmlJTs0h1q583O9b5V-zDbVXoLzUzRtOR5-gRNqOB5kuacPkUTQlKalGm2eY5ehLA7jiljF-iCk5KWGZmgvzd1DTpiV-OFdw9xi5fON64F3HeuxXELeP1pjr-4_dCAVwGwag2-BncY4nZorLHj6kfbHpG5jvbeRgvhKLeGO2hHSrTtHV7Ze_DYtng5dK7bDmG86Rr7Bwxeqxheomf1-Ay8Ovcp-n578-1qmaw-Lz5czVeJZoLGJB0NqDXlVDNeEZNlNck11Sorq4KCEVVGlYA0F0Wq66wgmhluSEFJbgTnJbApenvS7bz73UOIsrFBw36vWnB9kCIrSibGmqJ3p0XtXQgeatl52yg_SErkMQb5fwzyFIM8xzDyX58P9VUD5pF99n3EkxNuQ4TDI6z8L5kLJrhcbn7KH1_56nazWMj37B_WCZ1z</recordid><startdate>197106</startdate><enddate>197106</enddate><creator>AKAMATSU, Nobu</creator><creator>KAMIYA, Tsutomu</creator><creator>MAEDA, Hideyasu R.</creator><creator>ENDO, Noriko</creator><creator>FUKUI, Noriko</creator><creator>MIURA, Yoshiaki</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197106</creationdate><title>Effect of Growth Hormone upon the RNA Polymerase and Deoxythymidine Kinase Activities of Regenerating Liver in Hypophysectomized Rats</title><author>AKAMATSU, Nobu ; KAMIYA, Tsutomu ; MAEDA, Hideyasu R. ; ENDO, Noriko ; FUKUI, Noriko ; MIURA, Yoshiaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-2109fc151c35b0d44f06c1ca49b81ed7b41a7e26782cf480c3d5d08106d7559e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1971</creationdate><topic>Animals</topic><topic>Carbon Isotopes</topic><topic>Cell Nucleolus - enzymology</topic><topic>Cell Nucleus - enzymology</topic><topic>Growth Hormone - pharmacology</topic><topic>Hepatectomy</topic><topic>Hypophysectomy</topic><topic>Liver - enzymology</topic><topic>Liver Regeneration</topic><topic>Male</topic><topic>Rats</topic><topic>RNA Nucleotidyltransferases - metabolism</topic><topic>Stimulation, Chemical</topic><topic>Thymidine Kinase - metabolism</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>AKAMATSU, Nobu</creatorcontrib><creatorcontrib>KAMIYA, Tsutomu</creatorcontrib><creatorcontrib>MAEDA, Hideyasu R.</creatorcontrib><creatorcontrib>ENDO, Noriko</creatorcontrib><creatorcontrib>FUKUI, Noriko</creatorcontrib><creatorcontrib>MIURA, Yoshiaki</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of biochemistry (Tokyo)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>AKAMATSU, Nobu</au><au>KAMIYA, Tsutomu</au><au>MAEDA, Hideyasu R.</au><au>ENDO, Noriko</au><au>FUKUI, Noriko</au><au>MIURA, Yoshiaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Growth Hormone upon the RNA Polymerase and Deoxythymidine Kinase Activities of Regenerating Liver in Hypophysectomized Rats</atitle><jtitle>Journal of biochemistry (Tokyo)</jtitle><addtitle>J Biochem</addtitle><date>1971-06</date><risdate>1971</risdate><volume>69</volume><issue>6</issue><spage>1091</spage><epage>1095</epage><pages>1091-1095</pages><issn>0021-924X</issn><eissn>1756-2651</eissn><abstract>Regenerating rat liver showed markedly increased nuclear, nucleolar and chromatin RNA polymerase [EC 2.7.7.6] activities 6 hr after partial hepatectomy. Deoxy-thymidine kinase [EC 2.7.1.21] activity began to increase 20–24 hr after partial hepatectomy. However, after hypophysectomy and partial hepatectomy these enzymeactivities did not show corresponding increases. Treatment of hypophysectomized rats with growth hormone before partial hepatectomy resulted in increases in the RNA polymerase and deoxythymidine kinase activities 6hr and 20 hr, respectively, after partial hepatectomy. These results suggest that the growth hormone may be involved in initiation of liver regeneration.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>5091940</pmid><doi>10.1093/oxfordjournals.jbchem.a129562</doi><tpages>5</tpages></addata></record> |
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| ispartof | Journal of biochemistry (Tokyo), 1971-06, Vol.69 (6), p.1091-1095 |
| issn | 0021-924X 1756-2651 |
| language | eng |
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| source | J-STAGE Free; MEDLINE; Free Full-Text Journals in Chemistry; Oxford University Press Journals Digital Archive Legacy |
| subjects | Animals Carbon Isotopes Cell Nucleolus - enzymology Cell Nucleus - enzymology Growth Hormone - pharmacology Hepatectomy Hypophysectomy Liver - enzymology Liver Regeneration Male Rats RNA Nucleotidyltransferases - metabolism Stimulation, Chemical Thymidine Kinase - metabolism Time Factors |
| title | Effect of Growth Hormone upon the RNA Polymerase and Deoxythymidine Kinase Activities of Regenerating Liver in Hypophysectomized Rats |
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