A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: prevalence, severity and impact on quality of life
Purpose This systematic review aimed to assess the literature for prevalence, severity, and impact on quality of life of salivary gland hypofunction and xerostomia induced by cancer therapies. Methods The electronic databases of MEDLINE/PubMed and EMBASE were searched for articles published in Engli...
Gespeichert in:
| Veröffentlicht in: | Supportive care in cancer 2010-08, Vol.18 (8), p.1039-1060 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1060 |
|---|---|
| container_issue | 8 |
| container_start_page | 1039 |
| container_title | Supportive care in cancer |
| container_volume | 18 |
| creator | Jensen, S. B. Pedersen, A. M. L. Vissink, A. Andersen, E. Brown, C. G. Davies, A. N. Dutilh, J. Fulton, J. S. Jankovic, L. Lopes, N. N. F. Mello, A. L. S. Muniz, L. V. Murdoch-Kinch, C. A. Nair, R. G. Napeñas, J. J. Nogueira-Rodrigues, A. Saunders, D. Stirling, B. von Bültzingslöwen, I. Weikel, D. S. Elting, L. S. Spijkervet, F. K. L. Brennan, M. T. |
| description | Purpose
This systematic review aimed to assess the literature for prevalence, severity, and impact on quality of life of salivary gland hypofunction and xerostomia induced by cancer therapies.
Methods
The electronic databases of MEDLINE/PubMed and EMBASE were searched for articles published in English since the 1989 NIH Development Consensus Conference on the Oral Complications of Cancer Therapies until 2008 inclusive. Two independent reviewers extracted information regarding study design, study population, interventions, outcome measures, results and conclusions for each article.
Results
The inclusion criteria were met by 184 articles covering salivary gland hypofunction and xerostomia induced by conventional, 3D conformal radiotherapy or intensity-modulated radiotherapy in head and neck cancer patients, cancer chemotherapy, total body irradiation/hematopoietic stem cell transplantation, radioactive iodine treatment, and immunotherapy.
Conclusions
Salivary gland hypofunction and xerostomia are induced by radiotherapy in the head and neck region depending on the cumulative radiation dose to the gland tissue. Treatment focus should be on optimized/new approaches to further reduce the dose to the parotids, and particularly submandibular and minor salivary glands, as these glands are major contributors to moistening of oral tissues. Other cancer treatments also induce salivary gland hypofunction, although to a lesser severity, and in the case of chemotherapy and immunotherapy, the adverse effect is temporary. Fields of sparse literature included pediatric cancer populations, cancer chemotherapy, radioactive iodine treatment, total body irradiation/hematopoietic stem cell transplantation, and immunotherapy. |
| doi_str_mv | 10.1007/s00520-010-0827-8 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_748935408</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A358058242</galeid><sourcerecordid>A358058242</sourcerecordid><originalsourceid>FETCH-LOGICAL-c503t-a081c7e9f743b35aff4d32784703636f14b7a9fdbf597e316bb74b2cbc8d882e3</originalsourceid><addsrcrecordid>eNp1Ustu1DAUjRCIDoUPYIMsWLAhxc_Y6W5UlYdUiQ2sLce5nrrKq3YyMJ_BH_cOKSAQyLIsHZ977usUxXNGzxil-m2mVHFaUobXcF2aB8WGSSFKLUT9sNjQWrJSCqVOiic531DKtFb8cXHCKRfaULUpvm9JPuQZejdHTxLsI3wlYyDZdXHv0oHsOje05PowjWEZ_BzHgRyBb5DGPI99dCQO7eKhJc2BeDd4SGS-huSmCPmcTCjpOkD4DcmwhxTnww-B2E_OzwTlbhfMhShm7WKAp8Wj4LoMz-7f0-LLu8vPFx_Kq0_vP15sr0qvqJhLRw3zGuqgpWiEciHIVnBtpKaiElVgstGuDm0TVK1BsKpptGy4b7xpjeEgTovXq-6UxtsF8mz7mD102C-MS7ZamlooSQ0yX_7FvBmXNGBx1lS0VqbiDEmvVtIO27VxCOOcnD9K2q1QOGvDJUfW2T9YeFroox8HCBHxPwLYGuBx3jlBsFOKPS7GMmqPJrCrCSyawB5NYI_1vrivd2l6aH9F_Nw6EvhKyPg17CD9buj_qnfdmb1I</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>860958621</pqid></control><display><type>article</type><title>A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: prevalence, severity and impact on quality of life</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Jensen, S. B. ; Pedersen, A. M. L. ; Vissink, A. ; Andersen, E. ; Brown, C. G. ; Davies, A. N. ; Dutilh, J. ; Fulton, J. S. ; Jankovic, L. ; Lopes, N. N. F. ; Mello, A. L. S. ; Muniz, L. V. ; Murdoch-Kinch, C. A. ; Nair, R. G. ; Napeñas, J. J. ; Nogueira-Rodrigues, A. ; Saunders, D. ; Stirling, B. ; von Bültzingslöwen, I. ; Weikel, D. S. ; Elting, L. S. ; Spijkervet, F. K. L. ; Brennan, M. T.</creator><creatorcontrib>Jensen, S. B. ; Pedersen, A. M. L. ; Vissink, A. ; Andersen, E. ; Brown, C. G. ; Davies, A. N. ; Dutilh, J. ; Fulton, J. S. ; Jankovic, L. ; Lopes, N. N. F. ; Mello, A. L. S. ; Muniz, L. V. ; Murdoch-Kinch, C. A. ; Nair, R. G. ; Napeñas, J. J. ; Nogueira-Rodrigues, A. ; Saunders, D. ; Stirling, B. ; von Bültzingslöwen, I. ; Weikel, D. S. ; Elting, L. S. ; Spijkervet, F. K. L. ; Brennan, M. T. ; Salivary Gland Hypofunction/Xerostomia Section, Oral Care Study Group, Multinational Association of Supportive Care in Cancer (MASCC)/International Society of Oral Oncology (ISOO)</creatorcontrib><description>Purpose
This systematic review aimed to assess the literature for prevalence, severity, and impact on quality of life of salivary gland hypofunction and xerostomia induced by cancer therapies.
Methods
The electronic databases of MEDLINE/PubMed and EMBASE were searched for articles published in English since the 1989 NIH Development Consensus Conference on the Oral Complications of Cancer Therapies until 2008 inclusive. Two independent reviewers extracted information regarding study design, study population, interventions, outcome measures, results and conclusions for each article.
Results
The inclusion criteria were met by 184 articles covering salivary gland hypofunction and xerostomia induced by conventional, 3D conformal radiotherapy or intensity-modulated radiotherapy in head and neck cancer patients, cancer chemotherapy, total body irradiation/hematopoietic stem cell transplantation, radioactive iodine treatment, and immunotherapy.
Conclusions
Salivary gland hypofunction and xerostomia are induced by radiotherapy in the head and neck region depending on the cumulative radiation dose to the gland tissue. Treatment focus should be on optimized/new approaches to further reduce the dose to the parotids, and particularly submandibular and minor salivary glands, as these glands are major contributors to moistening of oral tissues. Other cancer treatments also induce salivary gland hypofunction, although to a lesser severity, and in the case of chemotherapy and immunotherapy, the adverse effect is temporary. Fields of sparse literature included pediatric cancer populations, cancer chemotherapy, radioactive iodine treatment, total body irradiation/hematopoietic stem cell transplantation, and immunotherapy.</description><identifier>ISSN: 0941-4355</identifier><identifier>EISSN: 1433-7339</identifier><identifier>DOI: 10.1007/s00520-010-0827-8</identifier><identifier>PMID: 20237805</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Antimitotic agents ; Antineoplastic agents ; Body fluids ; Cancer ; Chemotherapy ; Complications and side effects ; Evidence-Based Emergency Medicine ; Humans ; Immunotherapy ; Medicine ; Medicine & Public Health ; Neoplasms - therapy ; Nuclear radiation ; Nursing ; Nursing Research ; Oncology ; Original Article ; Pain Medicine ; Practice Guidelines as Topic ; Prevalence ; Prevalence studies (Epidemiology) ; Quality of Life ; Radiotherapy ; Rehabilitation Medicine ; Salivary Gland Diseases - epidemiology ; Salivary Gland Diseases - etiology ; Salivary Gland Diseases - physiopathology ; Severity of Illness Index ; Systematic review ; Xerostomia ; Xerostomia - epidemiology ; Xerostomia - etiology ; Xerostomia - physiopathology</subject><ispartof>Supportive care in cancer, 2010-08, Vol.18 (8), p.1039-1060</ispartof><rights>Springer-Verlag 2010</rights><rights>COPYRIGHT 2010 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-a081c7e9f743b35aff4d32784703636f14b7a9fdbf597e316bb74b2cbc8d882e3</citedby><cites>FETCH-LOGICAL-c503t-a081c7e9f743b35aff4d32784703636f14b7a9fdbf597e316bb74b2cbc8d882e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00520-010-0827-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00520-010-0827-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20237805$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jensen, S. B.</creatorcontrib><creatorcontrib>Pedersen, A. M. L.</creatorcontrib><creatorcontrib>Vissink, A.</creatorcontrib><creatorcontrib>Andersen, E.</creatorcontrib><creatorcontrib>Brown, C. G.</creatorcontrib><creatorcontrib>Davies, A. N.</creatorcontrib><creatorcontrib>Dutilh, J.</creatorcontrib><creatorcontrib>Fulton, J. S.</creatorcontrib><creatorcontrib>Jankovic, L.</creatorcontrib><creatorcontrib>Lopes, N. N. F.</creatorcontrib><creatorcontrib>Mello, A. L. S.</creatorcontrib><creatorcontrib>Muniz, L. V.</creatorcontrib><creatorcontrib>Murdoch-Kinch, C. A.</creatorcontrib><creatorcontrib>Nair, R. G.</creatorcontrib><creatorcontrib>Napeñas, J. J.</creatorcontrib><creatorcontrib>Nogueira-Rodrigues, A.</creatorcontrib><creatorcontrib>Saunders, D.</creatorcontrib><creatorcontrib>Stirling, B.</creatorcontrib><creatorcontrib>von Bültzingslöwen, I.</creatorcontrib><creatorcontrib>Weikel, D. S.</creatorcontrib><creatorcontrib>Elting, L. S.</creatorcontrib><creatorcontrib>Spijkervet, F. K. L.</creatorcontrib><creatorcontrib>Brennan, M. T.</creatorcontrib><creatorcontrib>Salivary Gland Hypofunction/Xerostomia Section, Oral Care Study Group, Multinational Association of Supportive Care in Cancer (MASCC)/International Society of Oral Oncology (ISOO)</creatorcontrib><title>A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: prevalence, severity and impact on quality of life</title><title>Supportive care in cancer</title><addtitle>Support Care Cancer</addtitle><addtitle>Support Care Cancer</addtitle><description>Purpose
This systematic review aimed to assess the literature for prevalence, severity, and impact on quality of life of salivary gland hypofunction and xerostomia induced by cancer therapies.
Methods
The electronic databases of MEDLINE/PubMed and EMBASE were searched for articles published in English since the 1989 NIH Development Consensus Conference on the Oral Complications of Cancer Therapies until 2008 inclusive. Two independent reviewers extracted information regarding study design, study population, interventions, outcome measures, results and conclusions for each article.
Results
The inclusion criteria were met by 184 articles covering salivary gland hypofunction and xerostomia induced by conventional, 3D conformal radiotherapy or intensity-modulated radiotherapy in head and neck cancer patients, cancer chemotherapy, total body irradiation/hematopoietic stem cell transplantation, radioactive iodine treatment, and immunotherapy.
Conclusions
Salivary gland hypofunction and xerostomia are induced by radiotherapy in the head and neck region depending on the cumulative radiation dose to the gland tissue. Treatment focus should be on optimized/new approaches to further reduce the dose to the parotids, and particularly submandibular and minor salivary glands, as these glands are major contributors to moistening of oral tissues. Other cancer treatments also induce salivary gland hypofunction, although to a lesser severity, and in the case of chemotherapy and immunotherapy, the adverse effect is temporary. Fields of sparse literature included pediatric cancer populations, cancer chemotherapy, radioactive iodine treatment, total body irradiation/hematopoietic stem cell transplantation, and immunotherapy.</description><subject>Antimitotic agents</subject><subject>Antineoplastic agents</subject><subject>Body fluids</subject><subject>Cancer</subject><subject>Chemotherapy</subject><subject>Complications and side effects</subject><subject>Evidence-Based Emergency Medicine</subject><subject>Humans</subject><subject>Immunotherapy</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neoplasms - therapy</subject><subject>Nuclear radiation</subject><subject>Nursing</subject><subject>Nursing Research</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Pain Medicine</subject><subject>Practice Guidelines as Topic</subject><subject>Prevalence</subject><subject>Prevalence studies (Epidemiology)</subject><subject>Quality of Life</subject><subject>Radiotherapy</subject><subject>Rehabilitation Medicine</subject><subject>Salivary Gland Diseases - epidemiology</subject><subject>Salivary Gland Diseases - etiology</subject><subject>Salivary Gland Diseases - physiopathology</subject><subject>Severity of Illness Index</subject><subject>Systematic review</subject><subject>Xerostomia</subject><subject>Xerostomia - epidemiology</subject><subject>Xerostomia - etiology</subject><subject>Xerostomia - physiopathology</subject><issn>0941-4355</issn><issn>1433-7339</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1Ustu1DAUjRCIDoUPYIMsWLAhxc_Y6W5UlYdUiQ2sLce5nrrKq3YyMJ_BH_cOKSAQyLIsHZ977usUxXNGzxil-m2mVHFaUobXcF2aB8WGSSFKLUT9sNjQWrJSCqVOiic531DKtFb8cXHCKRfaULUpvm9JPuQZejdHTxLsI3wlYyDZdXHv0oHsOje05PowjWEZ_BzHgRyBb5DGPI99dCQO7eKhJc2BeDd4SGS-huSmCPmcTCjpOkD4DcmwhxTnww-B2E_OzwTlbhfMhShm7WKAp8Wj4LoMz-7f0-LLu8vPFx_Kq0_vP15sr0qvqJhLRw3zGuqgpWiEciHIVnBtpKaiElVgstGuDm0TVK1BsKpptGy4b7xpjeEgTovXq-6UxtsF8mz7mD102C-MS7ZamlooSQ0yX_7FvBmXNGBx1lS0VqbiDEmvVtIO27VxCOOcnD9K2q1QOGvDJUfW2T9YeFroox8HCBHxPwLYGuBx3jlBsFOKPS7GMmqPJrCrCSyawB5NYI_1vrivd2l6aH9F_Nw6EvhKyPg17CD9buj_qnfdmb1I</recordid><startdate>20100801</startdate><enddate>20100801</enddate><creator>Jensen, S. B.</creator><creator>Pedersen, A. M. L.</creator><creator>Vissink, A.</creator><creator>Andersen, E.</creator><creator>Brown, C. G.</creator><creator>Davies, A. N.</creator><creator>Dutilh, J.</creator><creator>Fulton, J. S.</creator><creator>Jankovic, L.</creator><creator>Lopes, N. N. F.</creator><creator>Mello, A. L. S.</creator><creator>Muniz, L. V.</creator><creator>Murdoch-Kinch, C. A.</creator><creator>Nair, R. G.</creator><creator>Napeñas, J. J.</creator><creator>Nogueira-Rodrigues, A.</creator><creator>Saunders, D.</creator><creator>Stirling, B.</creator><creator>von Bültzingslöwen, I.</creator><creator>Weikel, D. S.</creator><creator>Elting, L. S.</creator><creator>Spijkervet, F. K. L.</creator><creator>Brennan, M. T.</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88J</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HEHIP</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2R</scope><scope>M2S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20100801</creationdate><title>A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: prevalence, severity and impact on quality of life</title><author>Jensen, S. B. ; Pedersen, A. M. L. ; Vissink, A. ; Andersen, E. ; Brown, C. G. ; Davies, A. N. ; Dutilh, J. ; Fulton, J. S. ; Jankovic, L. ; Lopes, N. N. F. ; Mello, A. L. S. ; Muniz, L. V. ; Murdoch-Kinch, C. A. ; Nair, R. G. ; Napeñas, J. J. ; Nogueira-Rodrigues, A. ; Saunders, D. ; Stirling, B. ; von Bültzingslöwen, I. ; Weikel, D. S. ; Elting, L. S. ; Spijkervet, F. K. L. ; Brennan, M. T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-a081c7e9f743b35aff4d32784703636f14b7a9fdbf597e316bb74b2cbc8d882e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Antimitotic agents</topic><topic>Antineoplastic agents</topic><topic>Body fluids</topic><topic>Cancer</topic><topic>Chemotherapy</topic><topic>Complications and side effects</topic><topic>Evidence-Based Emergency Medicine</topic><topic>Humans</topic><topic>Immunotherapy</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neoplasms - therapy</topic><topic>Nuclear radiation</topic><topic>Nursing</topic><topic>Nursing Research</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Pain Medicine</topic><topic>Practice Guidelines as Topic</topic><topic>Prevalence</topic><topic>Prevalence studies (Epidemiology)</topic><topic>Quality of Life</topic><topic>Radiotherapy</topic><topic>Rehabilitation Medicine</topic><topic>Salivary Gland Diseases - epidemiology</topic><topic>Salivary Gland Diseases - etiology</topic><topic>Salivary Gland Diseases - physiopathology</topic><topic>Severity of Illness Index</topic><topic>Systematic review</topic><topic>Xerostomia</topic><topic>Xerostomia - epidemiology</topic><topic>Xerostomia - etiology</topic><topic>Xerostomia - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jensen, S. B.</creatorcontrib><creatorcontrib>Pedersen, A. M. L.</creatorcontrib><creatorcontrib>Vissink, A.</creatorcontrib><creatorcontrib>Andersen, E.</creatorcontrib><creatorcontrib>Brown, C. G.</creatorcontrib><creatorcontrib>Davies, A. N.</creatorcontrib><creatorcontrib>Dutilh, J.</creatorcontrib><creatorcontrib>Fulton, J. S.</creatorcontrib><creatorcontrib>Jankovic, L.</creatorcontrib><creatorcontrib>Lopes, N. N. F.</creatorcontrib><creatorcontrib>Mello, A. L. S.</creatorcontrib><creatorcontrib>Muniz, L. V.</creatorcontrib><creatorcontrib>Murdoch-Kinch, C. A.</creatorcontrib><creatorcontrib>Nair, R. G.</creatorcontrib><creatorcontrib>Napeñas, J. J.</creatorcontrib><creatorcontrib>Nogueira-Rodrigues, A.</creatorcontrib><creatorcontrib>Saunders, D.</creatorcontrib><creatorcontrib>Stirling, B.</creatorcontrib><creatorcontrib>von Bültzingslöwen, I.</creatorcontrib><creatorcontrib>Weikel, D. S.</creatorcontrib><creatorcontrib>Elting, L. S.</creatorcontrib><creatorcontrib>Spijkervet, F. K. L.</creatorcontrib><creatorcontrib>Brennan, M. T.</creatorcontrib><creatorcontrib>Salivary Gland Hypofunction/Xerostomia Section, Oral Care Study Group, Multinational Association of Supportive Care in Cancer (MASCC)/International Society of Oral Oncology (ISOO)</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Sociology Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Social Science Database</collection><collection>Sociology Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Supportive care in cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jensen, S. B.</au><au>Pedersen, A. M. L.</au><au>Vissink, A.</au><au>Andersen, E.</au><au>Brown, C. G.</au><au>Davies, A. N.</au><au>Dutilh, J.</au><au>Fulton, J. S.</au><au>Jankovic, L.</au><au>Lopes, N. N. F.</au><au>Mello, A. L. S.</au><au>Muniz, L. V.</au><au>Murdoch-Kinch, C. A.</au><au>Nair, R. G.</au><au>Napeñas, J. J.</au><au>Nogueira-Rodrigues, A.</au><au>Saunders, D.</au><au>Stirling, B.</au><au>von Bültzingslöwen, I.</au><au>Weikel, D. S.</au><au>Elting, L. S.</au><au>Spijkervet, F. K. L.</au><au>Brennan, M. T.</au><aucorp>Salivary Gland Hypofunction/Xerostomia Section, Oral Care Study Group, Multinational Association of Supportive Care in Cancer (MASCC)/International Society of Oral Oncology (ISOO)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: prevalence, severity and impact on quality of life</atitle><jtitle>Supportive care in cancer</jtitle><stitle>Support Care Cancer</stitle><addtitle>Support Care Cancer</addtitle><date>2010-08-01</date><risdate>2010</risdate><volume>18</volume><issue>8</issue><spage>1039</spage><epage>1060</epage><pages>1039-1060</pages><issn>0941-4355</issn><eissn>1433-7339</eissn><abstract>Purpose
This systematic review aimed to assess the literature for prevalence, severity, and impact on quality of life of salivary gland hypofunction and xerostomia induced by cancer therapies.
Methods
The electronic databases of MEDLINE/PubMed and EMBASE were searched for articles published in English since the 1989 NIH Development Consensus Conference on the Oral Complications of Cancer Therapies until 2008 inclusive. Two independent reviewers extracted information regarding study design, study population, interventions, outcome measures, results and conclusions for each article.
Results
The inclusion criteria were met by 184 articles covering salivary gland hypofunction and xerostomia induced by conventional, 3D conformal radiotherapy or intensity-modulated radiotherapy in head and neck cancer patients, cancer chemotherapy, total body irradiation/hematopoietic stem cell transplantation, radioactive iodine treatment, and immunotherapy.
Conclusions
Salivary gland hypofunction and xerostomia are induced by radiotherapy in the head and neck region depending on the cumulative radiation dose to the gland tissue. Treatment focus should be on optimized/new approaches to further reduce the dose to the parotids, and particularly submandibular and minor salivary glands, as these glands are major contributors to moistening of oral tissues. Other cancer treatments also induce salivary gland hypofunction, although to a lesser severity, and in the case of chemotherapy and immunotherapy, the adverse effect is temporary. Fields of sparse literature included pediatric cancer populations, cancer chemotherapy, radioactive iodine treatment, total body irradiation/hematopoietic stem cell transplantation, and immunotherapy.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>20237805</pmid><doi>10.1007/s00520-010-0827-8</doi><tpages>22</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0941-4355 |
| ispartof | Supportive care in cancer, 2010-08, Vol.18 (8), p.1039-1060 |
| issn | 0941-4355 1433-7339 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_748935408 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Antimitotic agents Antineoplastic agents Body fluids Cancer Chemotherapy Complications and side effects Evidence-Based Emergency Medicine Humans Immunotherapy Medicine Medicine & Public Health Neoplasms - therapy Nuclear radiation Nursing Nursing Research Oncology Original Article Pain Medicine Practice Guidelines as Topic Prevalence Prevalence studies (Epidemiology) Quality of Life Radiotherapy Rehabilitation Medicine Salivary Gland Diseases - epidemiology Salivary Gland Diseases - etiology Salivary Gland Diseases - physiopathology Severity of Illness Index Systematic review Xerostomia Xerostomia - epidemiology Xerostomia - etiology Xerostomia - physiopathology |
| title | A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: prevalence, severity and impact on quality of life |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T09%3A30%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20systematic%20review%20of%20salivary%20gland%20hypofunction%20and%20xerostomia%20induced%20by%20cancer%20therapies:%20prevalence,%20severity%20and%20impact%20on%20quality%20of%20life&rft.jtitle=Supportive%20care%20in%20cancer&rft.au=Jensen,%20S.%20B.&rft.aucorp=Salivary%20Gland%20Hypofunction/Xerostomia%20Section,%20Oral%20Care%20Study%20Group,%20Multinational%20Association%20of%20Supportive%20Care%20in%20Cancer%20(MASCC)/International%20Society%20of%20Oral%20Oncology%20(ISOO)&rft.date=2010-08-01&rft.volume=18&rft.issue=8&rft.spage=1039&rft.epage=1060&rft.pages=1039-1060&rft.issn=0941-4355&rft.eissn=1433-7339&rft_id=info:doi/10.1007/s00520-010-0827-8&rft_dat=%3Cgale_proqu%3EA358058242%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=860958621&rft_id=info:pmid/20237805&rft_galeid=A358058242&rfr_iscdi=true |