The genetics of central corneal thickness
Evidence in the recent literature has highlighted the importance of central corneal thickness (CCT) in relation to several ocular and non-ocular conditions. Most notably, thinner CCT has been identified as a risk factor for open-angle glaucoma. Despite having an extensive knowledge of the structure...
Gespeichert in:
| Veröffentlicht in: | British journal of ophthalmology 2010-08, Vol.94 (8), p.971-976 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 976 |
|---|---|
| container_issue | 8 |
| container_start_page | 971 |
| container_title | British journal of ophthalmology |
| container_volume | 94 |
| creator | Dimasi, D P Burdon, K P Craig, J E |
| description | Evidence in the recent literature has highlighted the importance of central corneal thickness (CCT) in relation to several ocular and non-ocular conditions. Most notably, thinner CCT has been identified as a risk factor for open-angle glaucoma. Despite having an extensive knowledge of the structure and function of the cornea, little is known about the pathways that determine CCT. There are data to suggest however that CCT has a strong genetic component. Heritability studies conducted in twins and family pedigrees indicate that CCT is one of the most highly heritable human traits, whereas data from a diverse range of ethnic groups show clear ethnic-related differences in CCT. Extreme CCT measurements have also been associated with rare genetic diseases. Although there is strong evidence supporting a genetic component to normal CCT variation, to date, no genes have been identified. This review investigates the current literature surrounding this topic and explores the significance of understanding the genetics of CCT and how this might benefit the field of open-angle glaucoma treatment and research. |
| doi_str_mv | 10.1136/bjo.2009.162735 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_748934549</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>748934549</sourcerecordid><originalsourceid>FETCH-LOGICAL-b427t-cf3b35aafca2eda68593c571dcf7d4a6134d43ccec4600035326886ce7256b383</originalsourceid><addsrcrecordid>eNqF0c9LwzAUB_AgipvTszcZiIhCt7z8bI8y_AVjXqZ4C2maum5dO5MW9L83o2OCF0-PkE8e732D0DngEQAV43RZjwjGyQgEkZQfoD4wEUcEy-QQ9THGMgIQ0EMn3i_DkQiQx6gHCeeCAO-jm_nCDj9sZZvC-GGdD42tGqfLoaldZUNtFoVZVdb7U3SU69Lbs10doNeH-_nkKZq-PD5P7qZRyohsIpPTlHKtc6OJzbSIeUINl5CZXGZMC6AsY9QYa5gIA1FOiYhjYawkXKQ0pgN03fXduPqztb5R68IbW5a6snXrlWRxQhlnSZCXf-Sybl0VhlMgZZwwIASCGnfKuNp7Z3O1ccVau28FWG1DVCFEtQ1RdSGGFxe7vm26ttmv36UWwNUOaG90mTtdmcLvHaFY4IRvV4k6V_jGfu3vtVspIankavY2UU_hT2YxB_Ue_G3n0_Xy3yl_ACLjk2g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1778941221</pqid></control><display><type>article</type><title>The genetics of central corneal thickness</title><source>MEDLINE</source><source>BMJ Journals - NESLi2</source><source>PubMed Central</source><creator>Dimasi, D P ; Burdon, K P ; Craig, J E</creator><creatorcontrib>Dimasi, D P ; Burdon, K P ; Craig, J E</creatorcontrib><description>Evidence in the recent literature has highlighted the importance of central corneal thickness (CCT) in relation to several ocular and non-ocular conditions. Most notably, thinner CCT has been identified as a risk factor for open-angle glaucoma. Despite having an extensive knowledge of the structure and function of the cornea, little is known about the pathways that determine CCT. There are data to suggest however that CCT has a strong genetic component. Heritability studies conducted in twins and family pedigrees indicate that CCT is one of the most highly heritable human traits, whereas data from a diverse range of ethnic groups show clear ethnic-related differences in CCT. Extreme CCT measurements have also been associated with rare genetic diseases. Although there is strong evidence supporting a genetic component to normal CCT variation, to date, no genes have been identified. This review investigates the current literature surrounding this topic and explores the significance of understanding the genetics of CCT and how this might benefit the field of open-angle glaucoma treatment and research.</description><identifier>ISSN: 0007-1161</identifier><identifier>EISSN: 1468-2079</identifier><identifier>DOI: 10.1136/bjo.2009.162735</identifier><identifier>PMID: 19556215</identifier><identifier>CODEN: BJOPAL</identifier><language>eng</language><publisher>BMA House, Tavistock Square, London, WC1H 9JR: BMJ Publishing Group Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Central corneal thickness ; cornea ; Cornea - anatomy & histology ; Cornea - diagnostic imaging ; Cornea - pathology ; Estimates ; Ethnic Groups - genetics ; ethnicity ; Genes ; Genetics ; Genomes ; Glaucoma ; Glaucoma, Open-Angle - genetics ; Glaucoma, Open-Angle - pathology ; heritability ; Humans ; Measurement techniques ; Medical personnel ; Medical sciences ; Middle Aged ; Miscellaneous ; open-angle glaucoma ; Ophthalmology ; Population ; Quantitative Trait, Heritable ; Studies ; Twins ; Ultrasonic imaging ; Ultrasonography</subject><ispartof>British journal of ophthalmology, 2010-08, Vol.94 (8), p.971-976</ispartof><rights>2010, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright: 2010 (c) 2010, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b427t-cf3b35aafca2eda68593c571dcf7d4a6134d43ccec4600035326886ce7256b383</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://bjo.bmj.com/content/94/8/971.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttp://bjo.bmj.com/content/94/8/971.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,313,314,776,780,788,3183,23550,27899,27901,27902,77343,77374</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23060958$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19556215$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dimasi, D P</creatorcontrib><creatorcontrib>Burdon, K P</creatorcontrib><creatorcontrib>Craig, J E</creatorcontrib><title>The genetics of central corneal thickness</title><title>British journal of ophthalmology</title><addtitle>Br J Ophthalmol</addtitle><description>Evidence in the recent literature has highlighted the importance of central corneal thickness (CCT) in relation to several ocular and non-ocular conditions. Most notably, thinner CCT has been identified as a risk factor for open-angle glaucoma. Despite having an extensive knowledge of the structure and function of the cornea, little is known about the pathways that determine CCT. There are data to suggest however that CCT has a strong genetic component. Heritability studies conducted in twins and family pedigrees indicate that CCT is one of the most highly heritable human traits, whereas data from a diverse range of ethnic groups show clear ethnic-related differences in CCT. Extreme CCT measurements have also been associated with rare genetic diseases. Although there is strong evidence supporting a genetic component to normal CCT variation, to date, no genes have been identified. This review investigates the current literature surrounding this topic and explores the significance of understanding the genetics of CCT and how this might benefit the field of open-angle glaucoma treatment and research.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Central corneal thickness</subject><subject>cornea</subject><subject>Cornea - anatomy & histology</subject><subject>Cornea - diagnostic imaging</subject><subject>Cornea - pathology</subject><subject>Estimates</subject><subject>Ethnic Groups - genetics</subject><subject>ethnicity</subject><subject>Genes</subject><subject>Genetics</subject><subject>Genomes</subject><subject>Glaucoma</subject><subject>Glaucoma, Open-Angle - genetics</subject><subject>Glaucoma, Open-Angle - pathology</subject><subject>heritability</subject><subject>Humans</subject><subject>Measurement techniques</subject><subject>Medical personnel</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>open-angle glaucoma</subject><subject>Ophthalmology</subject><subject>Population</subject><subject>Quantitative Trait, Heritable</subject><subject>Studies</subject><subject>Twins</subject><subject>Ultrasonic imaging</subject><subject>Ultrasonography</subject><issn>0007-1161</issn><issn>1468-2079</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqF0c9LwzAUB_AgipvTszcZiIhCt7z8bI8y_AVjXqZ4C2maum5dO5MW9L83o2OCF0-PkE8e732D0DngEQAV43RZjwjGyQgEkZQfoD4wEUcEy-QQ9THGMgIQ0EMn3i_DkQiQx6gHCeeCAO-jm_nCDj9sZZvC-GGdD42tGqfLoaldZUNtFoVZVdb7U3SU69Lbs10doNeH-_nkKZq-PD5P7qZRyohsIpPTlHKtc6OJzbSIeUINl5CZXGZMC6AsY9QYa5gIA1FOiYhjYawkXKQ0pgN03fXduPqztb5R68IbW5a6snXrlWRxQhlnSZCXf-Sybl0VhlMgZZwwIASCGnfKuNp7Z3O1ccVau28FWG1DVCFEtQ1RdSGGFxe7vm26ttmv36UWwNUOaG90mTtdmcLvHaFY4IRvV4k6V_jGfu3vtVspIankavY2UU_hT2YxB_Ue_G3n0_Xy3yl_ACLjk2g</recordid><startdate>20100801</startdate><enddate>20100801</enddate><creator>Dimasi, D P</creator><creator>Burdon, K P</creator><creator>Craig, J E</creator><general>BMJ Publishing Group Ltd</general><general>BMJ Publishing Group</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20100801</creationdate><title>The genetics of central corneal thickness</title><author>Dimasi, D P ; Burdon, K P ; Craig, J E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b427t-cf3b35aafca2eda68593c571dcf7d4a6134d43ccec4600035326886ce7256b383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Central corneal thickness</topic><topic>cornea</topic><topic>Cornea - anatomy & histology</topic><topic>Cornea - diagnostic imaging</topic><topic>Cornea - pathology</topic><topic>Estimates</topic><topic>Ethnic Groups - genetics</topic><topic>ethnicity</topic><topic>Genes</topic><topic>Genetics</topic><topic>Genomes</topic><topic>Glaucoma</topic><topic>Glaucoma, Open-Angle - genetics</topic><topic>Glaucoma, Open-Angle - pathology</topic><topic>heritability</topic><topic>Humans</topic><topic>Measurement techniques</topic><topic>Medical personnel</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>open-angle glaucoma</topic><topic>Ophthalmology</topic><topic>Population</topic><topic>Quantitative Trait, Heritable</topic><topic>Studies</topic><topic>Twins</topic><topic>Ultrasonic imaging</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dimasi, D P</creatorcontrib><creatorcontrib>Burdon, K P</creatorcontrib><creatorcontrib>Craig, J E</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dimasi, D P</au><au>Burdon, K P</au><au>Craig, J E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The genetics of central corneal thickness</atitle><jtitle>British journal of ophthalmology</jtitle><addtitle>Br J Ophthalmol</addtitle><date>2010-08-01</date><risdate>2010</risdate><volume>94</volume><issue>8</issue><spage>971</spage><epage>976</epage><pages>971-976</pages><issn>0007-1161</issn><eissn>1468-2079</eissn><coden>BJOPAL</coden><abstract>Evidence in the recent literature has highlighted the importance of central corneal thickness (CCT) in relation to several ocular and non-ocular conditions. Most notably, thinner CCT has been identified as a risk factor for open-angle glaucoma. Despite having an extensive knowledge of the structure and function of the cornea, little is known about the pathways that determine CCT. There are data to suggest however that CCT has a strong genetic component. Heritability studies conducted in twins and family pedigrees indicate that CCT is one of the most highly heritable human traits, whereas data from a diverse range of ethnic groups show clear ethnic-related differences in CCT. Extreme CCT measurements have also been associated with rare genetic diseases. Although there is strong evidence supporting a genetic component to normal CCT variation, to date, no genes have been identified. This review investigates the current literature surrounding this topic and explores the significance of understanding the genetics of CCT and how this might benefit the field of open-angle glaucoma treatment and research.</abstract><cop>BMA House, Tavistock Square, London, WC1H 9JR</cop><pub>BMJ Publishing Group Ltd</pub><pmid>19556215</pmid><doi>10.1136/bjo.2009.162735</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-1161 |
| ispartof | British journal of ophthalmology, 2010-08, Vol.94 (8), p.971-976 |
| issn | 0007-1161 1468-2079 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_748934549 |
| source | MEDLINE; BMJ Journals - NESLi2; PubMed Central |
| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Central corneal thickness cornea Cornea - anatomy & histology Cornea - diagnostic imaging Cornea - pathology Estimates Ethnic Groups - genetics ethnicity Genes Genetics Genomes Glaucoma Glaucoma, Open-Angle - genetics Glaucoma, Open-Angle - pathology heritability Humans Measurement techniques Medical personnel Medical sciences Middle Aged Miscellaneous open-angle glaucoma Ophthalmology Population Quantitative Trait, Heritable Studies Twins Ultrasonic imaging Ultrasonography |
| title | The genetics of central corneal thickness |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T23%3A40%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20genetics%20of%20central%20corneal%20thickness&rft.jtitle=British%20journal%20of%20ophthalmology&rft.au=Dimasi,%20D%20P&rft.date=2010-08-01&rft.volume=94&rft.issue=8&rft.spage=971&rft.epage=976&rft.pages=971-976&rft.issn=0007-1161&rft.eissn=1468-2079&rft.coden=BJOPAL&rft_id=info:doi/10.1136/bjo.2009.162735&rft_dat=%3Cproquest_cross%3E748934549%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1778941221&rft_id=info:pmid/19556215&rfr_iscdi=true |