Developmental outcome of isolated fetal microcephaly
Objective To assess the neurodevelopmental outcome of children with prenatally diagnosed isolated microcephaly defined as head circumference more than 2 SD below the gestational mean. Methods Children aged 2–6 years who had been diagnosed in utero as having head circumference measurements more than...
Gespeichert in:
| Veröffentlicht in: | Ultrasound in obstetrics & gynecology 2010-08, Vol.36 (2), p.154-158 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 158 |
|---|---|
| container_issue | 2 |
| container_start_page | 154 |
| container_title | Ultrasound in obstetrics & gynecology |
| container_volume | 36 |
| creator | Stoler‐Poria, S. Lev, D. Schweiger, A. Lerman‐Sagie, T. Malinger, G. |
| description | Objective
To assess the neurodevelopmental outcome of children with prenatally diagnosed isolated microcephaly defined as head circumference more than 2 SD below the gestational mean.
Methods
Children aged 2–6 years who had been diagnosed in utero as having head circumference measurements more than 2 SD below the gestational mean were compared with normocephalic children, utilizing a standard neuropsychological battery. Comparisons were also made within the study group.
Results
HCs were between −2 and −4.8 SD, only one fetus having a HC below −3 SD. Children with a prenatal head circumference between 2 SD and 3 SD below the gestational mean did not differ significantly from the control group regarding cognitive, language and motor functioning. However, they exhibited more behavioral‐emotional problems. There were no significant differences between children who had suffered from intrauterine growth restriction and those who had not, or between those with familial and those with non‐familial microcephaly. Nevertheless, linear regression analysis showed that head circumference in utero helps predict cognitive functioning later in life.
Conclusions
Prenatally diagnosed head circumference between 2 SD and 3 SD below the gestational mean is not a risk factor for later abnormal neuropsychological development. Copyright © 2010 ISUOG. Published by John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/uog.7556 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_748934066</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1017971598</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4176-e68ce910faa994d1addf1b18da71b44f856423dfd9c091fb83aa27e842ab2c683</originalsourceid><addsrcrecordid>eNp90E1PwzAMBuAIgdgYSPwC1AuCS0eSpvk4ogEDadIu7FylqQNF6VKaFbR_T8YGO8HJlvzIll-EzgkeE4zpTe9fxiLP-QEaEsZVigXOD9EQK45TwRUdoJMQ3jDGnGX8GA1o7FTO5BCxO_gA59sGlivtEt-vjG8g8Tapg3d6BVViYTNpatN5A-2rdutTdGS1C3C2qyO0eLh_njyms_n0aXI7Sw0jgqfApQFFsNVaKVYRXVWWlERWWpCSMStzzmhW2UoZrIgtZaY1FSAZ1SU1XGYjdLXd23b-vYewKpo6GHBOL8H3oRBMqoxhzqO8_lcSTIQSJFdyT-M_IXRgi7arG92tIyo2aRYxzWKTZqQXu6192UD1C3_ii-ByB3Qw2tlOL00d9i7DIqd5Fl26dZ-1g_WfB4vFfPp9-AufDIp2</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1017971598</pqid></control><display><type>article</type><title>Developmental outcome of isolated fetal microcephaly</title><source>MEDLINE</source><source>Wiley Online Library Free Content</source><source>Access via Wiley Online Library</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Stoler‐Poria, S. ; Lev, D. ; Schweiger, A. ; Lerman‐Sagie, T. ; Malinger, G.</creator><creatorcontrib>Stoler‐Poria, S. ; Lev, D. ; Schweiger, A. ; Lerman‐Sagie, T. ; Malinger, G.</creatorcontrib><description>Objective
To assess the neurodevelopmental outcome of children with prenatally diagnosed isolated microcephaly defined as head circumference more than 2 SD below the gestational mean.
Methods
Children aged 2–6 years who had been diagnosed in utero as having head circumference measurements more than 2 SD below the gestational mean were compared with normocephalic children, utilizing a standard neuropsychological battery. Comparisons were also made within the study group.
Results
HCs were between −2 and −4.8 SD, only one fetus having a HC below −3 SD. Children with a prenatal head circumference between 2 SD and 3 SD below the gestational mean did not differ significantly from the control group regarding cognitive, language and motor functioning. However, they exhibited more behavioral‐emotional problems. There were no significant differences between children who had suffered from intrauterine growth restriction and those who had not, or between those with familial and those with non‐familial microcephaly. Nevertheless, linear regression analysis showed that head circumference in utero helps predict cognitive functioning later in life.
Conclusions
Prenatally diagnosed head circumference between 2 SD and 3 SD below the gestational mean is not a risk factor for later abnormal neuropsychological development. Copyright © 2010 ISUOG. Published by John Wiley & Sons, Ltd.</description><identifier>ISSN: 0960-7692</identifier><identifier>ISSN: 1469-0705</identifier><identifier>EISSN: 1469-0705</identifier><identifier>DOI: 10.1002/uog.7556</identifier><identifier>PMID: 20069548</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Biological and medical sciences ; brain ; Cephalometry - methods ; Child ; Child Development ; Child, Preschool ; Children ; Cognitive ability ; Female ; fetal CNS ; Fetuses ; Gynecology ; Gynecology. Andrology. Obstetrics ; Head ; head circumference ; Humans ; Intelligence - physiology ; Language ; Male ; Malformations of the nervous system ; Medical sciences ; microcephaly ; Microcephaly - complications ; Microcephaly - diagnostic imaging ; Microcephaly - psychology ; Microencephaly ; neurodevelopmental outcome ; Neurology ; neuropsychological outcome ; Neuropsychological Tests ; Obstetrics ; Pregnancy ; prenatal diagnosis ; Prognosis ; Regression analysis ; Retrospective Studies ; Risk factors ; third trimester ; Ultrasonography, Prenatal ; Ultrasound</subject><ispartof>Ultrasound in obstetrics & gynecology, 2010-08, Vol.36 (2), p.154-158</ispartof><rights>Copyright © 2010 ISUOG. Published by John Wiley & Sons, Ltd.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4176-e68ce910faa994d1addf1b18da71b44f856423dfd9c091fb83aa27e842ab2c683</citedby><cites>FETCH-LOGICAL-c4176-e68ce910faa994d1addf1b18da71b44f856423dfd9c091fb83aa27e842ab2c683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fuog.7556$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fuog.7556$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23075253$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20069548$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stoler‐Poria, S.</creatorcontrib><creatorcontrib>Lev, D.</creatorcontrib><creatorcontrib>Schweiger, A.</creatorcontrib><creatorcontrib>Lerman‐Sagie, T.</creatorcontrib><creatorcontrib>Malinger, G.</creatorcontrib><title>Developmental outcome of isolated fetal microcephaly</title><title>Ultrasound in obstetrics & gynecology</title><addtitle>Ultrasound Obstet Gynecol</addtitle><description>Objective
To assess the neurodevelopmental outcome of children with prenatally diagnosed isolated microcephaly defined as head circumference more than 2 SD below the gestational mean.
Methods
Children aged 2–6 years who had been diagnosed in utero as having head circumference measurements more than 2 SD below the gestational mean were compared with normocephalic children, utilizing a standard neuropsychological battery. Comparisons were also made within the study group.
Results
HCs were between −2 and −4.8 SD, only one fetus having a HC below −3 SD. Children with a prenatal head circumference between 2 SD and 3 SD below the gestational mean did not differ significantly from the control group regarding cognitive, language and motor functioning. However, they exhibited more behavioral‐emotional problems. There were no significant differences between children who had suffered from intrauterine growth restriction and those who had not, or between those with familial and those with non‐familial microcephaly. Nevertheless, linear regression analysis showed that head circumference in utero helps predict cognitive functioning later in life.
Conclusions
Prenatally diagnosed head circumference between 2 SD and 3 SD below the gestational mean is not a risk factor for later abnormal neuropsychological development. Copyright © 2010 ISUOG. Published by John Wiley & Sons, Ltd.</description><subject>Biological and medical sciences</subject><subject>brain</subject><subject>Cephalometry - methods</subject><subject>Child</subject><subject>Child Development</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Cognitive ability</subject><subject>Female</subject><subject>fetal CNS</subject><subject>Fetuses</subject><subject>Gynecology</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Head</subject><subject>head circumference</subject><subject>Humans</subject><subject>Intelligence - physiology</subject><subject>Language</subject><subject>Male</subject><subject>Malformations of the nervous system</subject><subject>Medical sciences</subject><subject>microcephaly</subject><subject>Microcephaly - complications</subject><subject>Microcephaly - diagnostic imaging</subject><subject>Microcephaly - psychology</subject><subject>Microencephaly</subject><subject>neurodevelopmental outcome</subject><subject>Neurology</subject><subject>neuropsychological outcome</subject><subject>Neuropsychological Tests</subject><subject>Obstetrics</subject><subject>Pregnancy</subject><subject>prenatal diagnosis</subject><subject>Prognosis</subject><subject>Regression analysis</subject><subject>Retrospective Studies</subject><subject>Risk factors</subject><subject>third trimester</subject><subject>Ultrasonography, Prenatal</subject><subject>Ultrasound</subject><issn>0960-7692</issn><issn>1469-0705</issn><issn>1469-0705</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90E1PwzAMBuAIgdgYSPwC1AuCS0eSpvk4ogEDadIu7FylqQNF6VKaFbR_T8YGO8HJlvzIll-EzgkeE4zpTe9fxiLP-QEaEsZVigXOD9EQK45TwRUdoJMQ3jDGnGX8GA1o7FTO5BCxO_gA59sGlivtEt-vjG8g8Tapg3d6BVViYTNpatN5A-2rdutTdGS1C3C2qyO0eLh_njyms_n0aXI7Sw0jgqfApQFFsNVaKVYRXVWWlERWWpCSMStzzmhW2UoZrIgtZaY1FSAZ1SU1XGYjdLXd23b-vYewKpo6GHBOL8H3oRBMqoxhzqO8_lcSTIQSJFdyT-M_IXRgi7arG92tIyo2aRYxzWKTZqQXu6192UD1C3_ii-ByB3Qw2tlOL00d9i7DIqd5Fl26dZ-1g_WfB4vFfPp9-AufDIp2</recordid><startdate>201008</startdate><enddate>201008</enddate><creator>Stoler‐Poria, S.</creator><creator>Lev, D.</creator><creator>Schweiger, A.</creator><creator>Lerman‐Sagie, T.</creator><creator>Malinger, G.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201008</creationdate><title>Developmental outcome of isolated fetal microcephaly</title><author>Stoler‐Poria, S. ; Lev, D. ; Schweiger, A. ; Lerman‐Sagie, T. ; Malinger, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4176-e68ce910faa994d1addf1b18da71b44f856423dfd9c091fb83aa27e842ab2c683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Biological and medical sciences</topic><topic>brain</topic><topic>Cephalometry - methods</topic><topic>Child</topic><topic>Child Development</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Cognitive ability</topic><topic>Female</topic><topic>fetal CNS</topic><topic>Fetuses</topic><topic>Gynecology</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Head</topic><topic>head circumference</topic><topic>Humans</topic><topic>Intelligence - physiology</topic><topic>Language</topic><topic>Male</topic><topic>Malformations of the nervous system</topic><topic>Medical sciences</topic><topic>microcephaly</topic><topic>Microcephaly - complications</topic><topic>Microcephaly - diagnostic imaging</topic><topic>Microcephaly - psychology</topic><topic>Microencephaly</topic><topic>neurodevelopmental outcome</topic><topic>Neurology</topic><topic>neuropsychological outcome</topic><topic>Neuropsychological Tests</topic><topic>Obstetrics</topic><topic>Pregnancy</topic><topic>prenatal diagnosis</topic><topic>Prognosis</topic><topic>Regression analysis</topic><topic>Retrospective Studies</topic><topic>Risk factors</topic><topic>third trimester</topic><topic>Ultrasonography, Prenatal</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stoler‐Poria, S.</creatorcontrib><creatorcontrib>Lev, D.</creatorcontrib><creatorcontrib>Schweiger, A.</creatorcontrib><creatorcontrib>Lerman‐Sagie, T.</creatorcontrib><creatorcontrib>Malinger, G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Ultrasound in obstetrics & gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stoler‐Poria, S.</au><au>Lev, D.</au><au>Schweiger, A.</au><au>Lerman‐Sagie, T.</au><au>Malinger, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Developmental outcome of isolated fetal microcephaly</atitle><jtitle>Ultrasound in obstetrics & gynecology</jtitle><addtitle>Ultrasound Obstet Gynecol</addtitle><date>2010-08</date><risdate>2010</risdate><volume>36</volume><issue>2</issue><spage>154</spage><epage>158</epage><pages>154-158</pages><issn>0960-7692</issn><issn>1469-0705</issn><eissn>1469-0705</eissn><abstract>Objective
To assess the neurodevelopmental outcome of children with prenatally diagnosed isolated microcephaly defined as head circumference more than 2 SD below the gestational mean.
Methods
Children aged 2–6 years who had been diagnosed in utero as having head circumference measurements more than 2 SD below the gestational mean were compared with normocephalic children, utilizing a standard neuropsychological battery. Comparisons were also made within the study group.
Results
HCs were between −2 and −4.8 SD, only one fetus having a HC below −3 SD. Children with a prenatal head circumference between 2 SD and 3 SD below the gestational mean did not differ significantly from the control group regarding cognitive, language and motor functioning. However, they exhibited more behavioral‐emotional problems. There were no significant differences between children who had suffered from intrauterine growth restriction and those who had not, or between those with familial and those with non‐familial microcephaly. Nevertheless, linear regression analysis showed that head circumference in utero helps predict cognitive functioning later in life.
Conclusions
Prenatally diagnosed head circumference between 2 SD and 3 SD below the gestational mean is not a risk factor for later abnormal neuropsychological development. Copyright © 2010 ISUOG. Published by John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>20069548</pmid><doi>10.1002/uog.7556</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0960-7692 |
| ispartof | Ultrasound in obstetrics & gynecology, 2010-08, Vol.36 (2), p.154-158 |
| issn | 0960-7692 1469-0705 1469-0705 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_748934066 |
| source | MEDLINE; Wiley Online Library Free Content; Access via Wiley Online Library; EZB-FREE-00999 freely available EZB journals |
| subjects | Biological and medical sciences brain Cephalometry - methods Child Child Development Child, Preschool Children Cognitive ability Female fetal CNS Fetuses Gynecology Gynecology. Andrology. Obstetrics Head head circumference Humans Intelligence - physiology Language Male Malformations of the nervous system Medical sciences microcephaly Microcephaly - complications Microcephaly - diagnostic imaging Microcephaly - psychology Microencephaly neurodevelopmental outcome Neurology neuropsychological outcome Neuropsychological Tests Obstetrics Pregnancy prenatal diagnosis Prognosis Regression analysis Retrospective Studies Risk factors third trimester Ultrasonography, Prenatal Ultrasound |
| title | Developmental outcome of isolated fetal microcephaly |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-19T12%3A37%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Developmental%20outcome%20of%20isolated%20fetal%20microcephaly&rft.jtitle=Ultrasound%20in%20obstetrics%20&%20gynecology&rft.au=Stoler%E2%80%90Poria,%20S.&rft.date=2010-08&rft.volume=36&rft.issue=2&rft.spage=154&rft.epage=158&rft.pages=154-158&rft.issn=0960-7692&rft.eissn=1469-0705&rft_id=info:doi/10.1002/uog.7556&rft_dat=%3Cproquest_cross%3E1017971598%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1017971598&rft_id=info:pmid/20069548&rfr_iscdi=true |