Oridonin induces G2/M cell cycle arrest and apoptosis through MAPK and p53 signaling pathways in HepG2 cells

Oridonin, the main active constituent of Isodon rubescen, has antihepatocarcinoma activity in experimental and clinical settings. The aims of the study were to explore the anticancer effect of oridonin in HepG2 cells and to investigate the underlying mechanisms. Results showed that oridonin treatmen...

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Veröffentlicht in:	Oncology reports 2010-09, Vol.24 (3), p.647-651
Hauptverfasser:	HUI WANG, YAN YE, CHU, Jian-Hong, ZHU, Guo-Yuan, LI, Ying-Wei, FONG, David W. F, YU, Zhi-Ling
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - pharmacology Apoptosis - drug effects Biological and medical sciences Carcinoma, Hepatocellular - enzymology Carcinoma, Hepatocellular - pathology Caspase 3 - metabolism Caspase 9 - metabolism CDC2 Protein Kinase Cell Cycle - drug effects Cell Division Cell Survival - drug effects Cyclin B - metabolism Cyclin B1 - metabolism Cyclin-Dependent Kinase Inhibitor p21 - metabolism Cyclin-Dependent Kinases Diterpenes, Kaurane - pharmacology Dose-Response Relationship, Drug Extracellular Signal-Regulated MAP Kinases - metabolism G2 Phase Hep G2 Cells Humans Inhibitory Concentration 50 JNK Mitogen-Activated Protein Kinases - metabolism Liver Neoplasms - enzymology Liver Neoplasms - pathology MAP Kinase Signaling System - drug effects Medical sciences p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylation Time Factors Tumor Suppressor Protein p53 - metabolism Tumors
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