Interleukin-18 and interferon-gamma polymorphisms in Brazilian human immunodeficiency virus-1-infected patients presenting with lipodystrophy syndrome
Cytokines play important roles in the pathogenesis of lipodystrophy syndrome (LS). Single nucleotide polymorphisms (SNPs) at positions −607(C/A) and −137(C/G) in the promoter region of the interleukin‐18 (IL‐18) gene and at position +874(T/A) of the interferon‐gamma (IFN‐γ) gene are related to the e...
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| Veröffentlicht in: | Tissue antigens 2010-08, Vol.76 (2), p.126-130 |
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| creator | Castelar, L. Silva, M. M. Castelli, E. C. Deghaide, N. H. S. Mendes-Junior, C. T. Machado, A. A. Donadi, E. A. Fernandes, A. P. M. |
| description | Cytokines play important roles in the pathogenesis of lipodystrophy syndrome (LS). Single nucleotide polymorphisms (SNPs) at positions −607(C/A) and −137(C/G) in the promoter region of the interleukin‐18 (IL‐18) gene and at position +874(T/A) of the interferon‐gamma (IFN‐γ) gene are related to the expression of these cytokines. To examine whether IL‐18 and IFN‐γ polymorphisms are associated with LS, these SNPs were genotyped in 88 human immunodeficiency virus (HIV)‐infected patients presenting LS, 79 HIV‐infected without LS, and 133 healthy controls. The −607A allele, −607AA genotype, and −137G/–607A and −137C/–607A haplotypes in the IL‐18 gene were over‐represented in HIV patients presenting LS. The −137G/−607C haplotype was associated with protection against LS. These results indicate that the −607(C/A) SNP is associated with LS development in HIV‐infected patients. |
| doi_str_mv | 10.1111/j.1399-0039.2010.01471.x |
| format | Article |
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M. ; Castelli, E. C. ; Deghaide, N. H. S. ; Mendes-Junior, C. T. ; Machado, A. A. ; Donadi, E. A. ; Fernandes, A. P. M.</creator><creatorcontrib>Castelar, L. ; Silva, M. M. ; Castelli, E. C. ; Deghaide, N. H. S. ; Mendes-Junior, C. T. ; Machado, A. A. ; Donadi, E. A. ; Fernandes, A. P. M.</creatorcontrib><description>Cytokines play important roles in the pathogenesis of lipodystrophy syndrome (LS). Single nucleotide polymorphisms (SNPs) at positions −607(C/A) and −137(C/G) in the promoter region of the interleukin‐18 (IL‐18) gene and at position +874(T/A) of the interferon‐gamma (IFN‐γ) gene are related to the expression of these cytokines. To examine whether IL‐18 and IFN‐γ polymorphisms are associated with LS, these SNPs were genotyped in 88 human immunodeficiency virus (HIV)‐infected patients presenting LS, 79 HIV‐infected without LS, and 133 healthy controls. The −607A allele, −607AA genotype, and −137G/–607A and −137C/–607A haplotypes in the IL‐18 gene were over‐represented in HIV patients presenting LS. The −137G/−607C haplotype was associated with protection against LS. These results indicate that the −607(C/A) SNP is associated with LS development in HIV‐infected patients.</description><identifier>ISSN: 0001-2815</identifier><identifier>EISSN: 1399-0039</identifier><identifier>DOI: 10.1111/j.1399-0039.2010.01471.x</identifier><identifier>PMID: 20331838</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Antiretroviral Therapy, Highly Active - adverse effects ; Base Sequence ; Brazil ; Case-Control Studies ; Development ; DNA Primers - genetics ; Female ; g-Interferon ; Genetic Predisposition to Disease ; Haplotypes ; highly active antiretroviral therapy ; HIV Infections - drug therapy ; HIV Infections - genetics ; HIV Infections - immunology ; HIV-1 ; HIV-Associated Lipodystrophy Syndrome - etiology ; HIV-Associated Lipodystrophy Syndrome - genetics ; HIV-Associated Lipodystrophy Syndrome - immunology ; Human immunodeficiency virus ; human immunodeficiency virus-1 ; human immunodeficiency virus-associated lipodystrophy syndrome ; Humans ; Immunodeficiency ; interferon-gamma ; Interferon-gamma - genetics ; Interleukin 18 ; Interleukin-18 - genetics ; Lipodystrophy ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Promoters ; Single-nucleotide polymorphism</subject><ispartof>Tissue antigens, 2010-08, Vol.76 (2), p.126-130</ispartof><rights>2010 John Wiley & Sons A/S</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4381-cc24ad1e9ff4d24ca8e1cbabdc8c62b06ed37be79eebb829d2401074c1909c6d3</citedby><cites>FETCH-LOGICAL-c4381-cc24ad1e9ff4d24ca8e1cbabdc8c62b06ed37be79eebb829d2401074c1909c6d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1399-0039.2010.01471.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1399-0039.2010.01471.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20331838$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Castelar, L.</creatorcontrib><creatorcontrib>Silva, M. M.</creatorcontrib><creatorcontrib>Castelli, E. C.</creatorcontrib><creatorcontrib>Deghaide, N. H. S.</creatorcontrib><creatorcontrib>Mendes-Junior, C. T.</creatorcontrib><creatorcontrib>Machado, A. A.</creatorcontrib><creatorcontrib>Donadi, E. A.</creatorcontrib><creatorcontrib>Fernandes, A. P. M.</creatorcontrib><title>Interleukin-18 and interferon-gamma polymorphisms in Brazilian human immunodeficiency virus-1-infected patients presenting with lipodystrophy syndrome</title><title>Tissue antigens</title><addtitle>Tissue Antigens</addtitle><description>Cytokines play important roles in the pathogenesis of lipodystrophy syndrome (LS). Single nucleotide polymorphisms (SNPs) at positions −607(C/A) and −137(C/G) in the promoter region of the interleukin‐18 (IL‐18) gene and at position +874(T/A) of the interferon‐gamma (IFN‐γ) gene are related to the expression of these cytokines. To examine whether IL‐18 and IFN‐γ polymorphisms are associated with LS, these SNPs were genotyped in 88 human immunodeficiency virus (HIV)‐infected patients presenting LS, 79 HIV‐infected without LS, and 133 healthy controls. The −607A allele, −607AA genotype, and −137G/–607A and −137C/–607A haplotypes in the IL‐18 gene were over‐represented in HIV patients presenting LS. The −137G/−607C haplotype was associated with protection against LS. These results indicate that the −607(C/A) SNP is associated with LS development in HIV‐infected patients.</description><subject>Adult</subject><subject>Antiretroviral Therapy, Highly Active - adverse effects</subject><subject>Base Sequence</subject><subject>Brazil</subject><subject>Case-Control Studies</subject><subject>Development</subject><subject>DNA Primers - genetics</subject><subject>Female</subject><subject>g-Interferon</subject><subject>Genetic Predisposition to Disease</subject><subject>Haplotypes</subject><subject>highly active antiretroviral therapy</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - genetics</subject><subject>HIV Infections - immunology</subject><subject>HIV-1</subject><subject>HIV-Associated Lipodystrophy Syndrome - etiology</subject><subject>HIV-Associated Lipodystrophy Syndrome - genetics</subject><subject>HIV-Associated Lipodystrophy Syndrome - immunology</subject><subject>Human immunodeficiency virus</subject><subject>human immunodeficiency virus-1</subject><subject>human immunodeficiency virus-associated lipodystrophy syndrome</subject><subject>Humans</subject><subject>Immunodeficiency</subject><subject>interferon-gamma</subject><subject>Interferon-gamma - genetics</subject><subject>Interleukin 18</subject><subject>Interleukin-18 - genetics</subject><subject>Lipodystrophy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Promoters</subject><subject>Single-nucleotide polymorphism</subject><issn>0001-2815</issn><issn>1399-0039</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcFu1DAQhiMEokvhFZBvnLzYcTaxDxzKCtqKVTlQVKkXy7EnXW9jJ9hJu-FBeF4ctuy5Ptijme__R_KfZYiSJU3n425JmRCYECaWOUldQouKLvcvssVx8DJbEEIozjldnWRvYtyRmRLidXaSE8YoZ3yR_bn0A4QWxnvrMeVIeYPs3GogdB7fKecU6rt2cl3otza6mMboc1C_bWuVR9vRpds6N_rOQGO1Ba8n9GDDGDHF1jegBzCoV0OaDBH1AWIqrL9Dj3bYotb2nZniELp-O6E4eRM6B2-zV41qI7x7ek-zn1-_XK8v8Ob7-eX6bIN1wTjFWueFMhRE0xQmL7TiQHWtaqO5LvOalGBYVUMlAOqa5yIx6beqQlNBhC4NO80-HHz70P0aIQ7S2aihbZWHboyyKrhgdFXRZ5Alo0VRlYnkB1KHLsYAjeyDdSpMkhI5xyd3ck5JzinJOT75Lz65T9L3T0vG2oE5Cv_nlYBPB-DRtjA921hen13NVdLjg97GAfZHvQr3sqxYtZI3V-fJ6nZD1z-I_Mb-Au7ivRg</recordid><startdate>201008</startdate><enddate>201008</enddate><creator>Castelar, L.</creator><creator>Silva, M. M.</creator><creator>Castelli, E. C.</creator><creator>Deghaide, N. H. S.</creator><creator>Mendes-Junior, C. T.</creator><creator>Machado, A. A.</creator><creator>Donadi, E. A.</creator><creator>Fernandes, A. P. M.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>201008</creationdate><title>Interleukin-18 and interferon-gamma polymorphisms in Brazilian human immunodeficiency virus-1-infected patients presenting with lipodystrophy syndrome</title><author>Castelar, L. ; Silva, M. M. ; Castelli, E. C. ; Deghaide, N. H. S. ; Mendes-Junior, C. T. ; Machado, A. A. ; Donadi, E. A. ; Fernandes, A. P. 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M.</creatorcontrib><creatorcontrib>Castelli, E. C.</creatorcontrib><creatorcontrib>Deghaide, N. H. S.</creatorcontrib><creatorcontrib>Mendes-Junior, C. T.</creatorcontrib><creatorcontrib>Machado, A. A.</creatorcontrib><creatorcontrib>Donadi, E. A.</creatorcontrib><creatorcontrib>Fernandes, A. P. M.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Tissue antigens</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Castelar, L.</au><au>Silva, M. M.</au><au>Castelli, E. C.</au><au>Deghaide, N. H. S.</au><au>Mendes-Junior, C. T.</au><au>Machado, A. A.</au><au>Donadi, E. A.</au><au>Fernandes, A. P. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interleukin-18 and interferon-gamma polymorphisms in Brazilian human immunodeficiency virus-1-infected patients presenting with lipodystrophy syndrome</atitle><jtitle>Tissue antigens</jtitle><addtitle>Tissue Antigens</addtitle><date>2010-08</date><risdate>2010</risdate><volume>76</volume><issue>2</issue><spage>126</spage><epage>130</epage><pages>126-130</pages><issn>0001-2815</issn><eissn>1399-0039</eissn><abstract>Cytokines play important roles in the pathogenesis of lipodystrophy syndrome (LS). Single nucleotide polymorphisms (SNPs) at positions −607(C/A) and −137(C/G) in the promoter region of the interleukin‐18 (IL‐18) gene and at position +874(T/A) of the interferon‐gamma (IFN‐γ) gene are related to the expression of these cytokines. To examine whether IL‐18 and IFN‐γ polymorphisms are associated with LS, these SNPs were genotyped in 88 human immunodeficiency virus (HIV)‐infected patients presenting LS, 79 HIV‐infected without LS, and 133 healthy controls. The −607A allele, −607AA genotype, and −137G/–607A and −137C/–607A haplotypes in the IL‐18 gene were over‐represented in HIV patients presenting LS. The −137G/−607C haplotype was associated with protection against LS. These results indicate that the −607(C/A) SNP is associated with LS development in HIV‐infected patients.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>20331838</pmid><doi>10.1111/j.1399-0039.2010.01471.x</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Antiretroviral Therapy, Highly Active - adverse effects Base Sequence Brazil Case-Control Studies Development DNA Primers - genetics Female g-Interferon Genetic Predisposition to Disease Haplotypes highly active antiretroviral therapy HIV Infections - drug therapy HIV Infections - genetics HIV Infections - immunology HIV-1 HIV-Associated Lipodystrophy Syndrome - etiology HIV-Associated Lipodystrophy Syndrome - genetics HIV-Associated Lipodystrophy Syndrome - immunology Human immunodeficiency virus human immunodeficiency virus-1 human immunodeficiency virus-associated lipodystrophy syndrome Humans Immunodeficiency interferon-gamma Interferon-gamma - genetics Interleukin 18 Interleukin-18 - genetics Lipodystrophy Male Middle Aged Polymorphism, Single Nucleotide Promoters Single-nucleotide polymorphism |
| title | Interleukin-18 and interferon-gamma polymorphisms in Brazilian human immunodeficiency virus-1-infected patients presenting with lipodystrophy syndrome |
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