Central nervous system activity of the proanthocyanidin-rich fraction obtained from Croton celtidifolius in rats
Objectives The aim of the present study was to evaluate the possible neurobehavioural effects in rats of the proanthocyanidin‐rich fraction (PRF) isolated from the bark of Croton celtidifolius (Euphorbiaceae). Methods Adult Wistar rats were treated with the PRF (0.3–30 mg/kg) and evaluated in diff...
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| Veröffentlicht in: | Journal of pharmacy and pharmacology 2010-08, Vol.62 (8), p.1061-1068 |
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| creator | Moreira, Eduardo L.G. Rial, Daniel Duarte, Filipe S. De Carvalho, Cristiane Ribeiro Horst, Heros Pizzolatti, Moacir G. Prediger, Rui D.S. Ribeiro-do-Valle, Rosa Maria |
| description | Objectives The aim of the present study was to evaluate the possible neurobehavioural effects in rats of the proanthocyanidin‐rich fraction (PRF) isolated from the bark of Croton celtidifolius (Euphorbiaceae).
Methods Adult Wistar rats were treated with the PRF (0.3–30 mg/kg) and evaluated in different behavioural paradigms classically used for the screening of drugs with psychoactive effects.
Key findings Acute intraperitoneal (i.p.) administration of PRF decreased spontaneous locomotor activity (open field arena and activity cage), enhanced the duration of ethyl ether‐induced hypnosis, increased the latency to the first convulsion induced by pentylenetetrazole (60 mg/kg, i.p.) and attenuated apomorphine‐induced (0.5 mg/kg, i.p.) stereotyped behaviour. In lower doses, PRF (0.3 or 3 mg/kg, i.p.) increased the frequency of open arm entries in the elevated plus‐maze test.
Conclusions The present findings suggest that the systemic administration of PRF induces a wide spectrum of behavioural alterations in rats, consistent with the putative existence of hypnosedative, anticonvulsant and anxiolytic compounds. |
| doi_str_mv | 10.1111/j.2042-7158.2010.01124.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_748931398</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>748931398</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4574-f3346785583775f79a88dab54603239ff5cb0f2a432e0054fc82f59ed32fe5743</originalsourceid><addsrcrecordid>eNqNkc1uGyEUhVHUKnHTvkLErqtxGX4GZhMptRKnVtRYUaNI3SA8AzLODLiAE8_bh6lTr8uGq8O5H5cDALBE0zKvb5spRhQXvGQiV1lFZYnpdH8CJseDD2CCEMYFYZycgU8xbhBCvKqqU3CGUVURRMsJ2M60S0F10Onw4ncRxiEm3UPVJPti0wC9gWmt4TZ45dLaN4NytrWuCLZZQxNGn3fQr5KyTrdZ8T2cBZ-y2OguZa_xnc1g62BQKX4GH43qov7yvp-Dx5vrX7Pb4u5-_mN2dVc0lHFaGEJoxQVjgnDODK-VEK1aMVohgkltDGtWyGBFCdYIMWoagQ2rdUuw0RlAzsHXAzdP_menY5K9jXmiTjmd3yk5FTUpSS2yUxycTfAxBm3kNthehUGWSI5xy40cU5VjqnKMW_6NW-5z68X7JbtVr9tj4798s-HyYHi1nR7-GywXy9vlWGZAcQDY_C37I0CFZ1lxwpl8-jmXv-fk-8Ni8SCX5A03CZ8y</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>748931398</pqid></control><display><type>article</type><title>Central nervous system activity of the proanthocyanidin-rich fraction obtained from Croton celtidifolius in rats</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Moreira, Eduardo L.G. ; Rial, Daniel ; Duarte, Filipe S. ; De Carvalho, Cristiane Ribeiro ; Horst, Heros ; Pizzolatti, Moacir G. ; Prediger, Rui D.S. ; Ribeiro-do-Valle, Rosa Maria</creator><creatorcontrib>Moreira, Eduardo L.G. ; Rial, Daniel ; Duarte, Filipe S. ; De Carvalho, Cristiane Ribeiro ; Horst, Heros ; Pizzolatti, Moacir G. ; Prediger, Rui D.S. ; Ribeiro-do-Valle, Rosa Maria</creatorcontrib><description>Objectives The aim of the present study was to evaluate the possible neurobehavioural effects in rats of the proanthocyanidin‐rich fraction (PRF) isolated from the bark of Croton celtidifolius (Euphorbiaceae).
Methods Adult Wistar rats were treated with the PRF (0.3–30 mg/kg) and evaluated in different behavioural paradigms classically used for the screening of drugs with psychoactive effects.
Key findings Acute intraperitoneal (i.p.) administration of PRF decreased spontaneous locomotor activity (open field arena and activity cage), enhanced the duration of ethyl ether‐induced hypnosis, increased the latency to the first convulsion induced by pentylenetetrazole (60 mg/kg, i.p.) and attenuated apomorphine‐induced (0.5 mg/kg, i.p.) stereotyped behaviour. In lower doses, PRF (0.3 or 3 mg/kg, i.p.) increased the frequency of open arm entries in the elevated plus‐maze test.
Conclusions The present findings suggest that the systemic administration of PRF induces a wide spectrum of behavioural alterations in rats, consistent with the putative existence of hypnosedative, anticonvulsant and anxiolytic compounds.</description><identifier>ISSN: 0022-3573</identifier><identifier>EISSN: 2042-7158</identifier><identifier>DOI: 10.1111/j.2042-7158.2010.01124.x</identifier><identifier>PMID: 20663041</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject><![CDATA[Anesthetics, Inhalation - pharmacology ; Animals ; Anti-Anxiety Agents - pharmacology ; Anticonvulsants - pharmacology ; Antipsychotic Agents - pharmacology ; Apomorphine - pharmacology ; Behavior, Animal - drug effects ; behaviour ; catechin ; central actions ; Central Nervous System Agents - administration & dosage ; Central Nervous System Agents - isolation & purification ; Central Nervous System Agents - pharmacology ; Consciousness - drug effects ; Croton - chemistry ; Croton celtidifolius ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Ether - pharmacology ; Hypnotics and Sedatives - pharmacology ; Injections, Intraperitoneal ; Male ; Motor Activity - drug effects ; Pentylenetetrazole ; Plant Bark ; Plant Extracts - administration & dosage ; Plant Extracts - pharmacology ; proanthocyanidin ; Proanthocyanidins - administration & dosage ; Proanthocyanidins - isolation & purification ; Proanthocyanidins - pharmacology ; Rats ; Rats, Wistar ; Seizures - chemically induced ; Seizures - prevention & control ; Stereotyped Behavior - drug effects]]></subject><ispartof>Journal of pharmacy and pharmacology, 2010-08, Vol.62 (8), p.1061-1068</ispartof><rights>2010 The Authors. Journal compilation © 2010 Royal Pharmaceutical Society of Great Britain</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4574-f3346785583775f79a88dab54603239ff5cb0f2a432e0054fc82f59ed32fe5743</citedby><cites>FETCH-LOGICAL-c4574-f3346785583775f79a88dab54603239ff5cb0f2a432e0054fc82f59ed32fe5743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.2042-7158.2010.01124.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.2042-7158.2010.01124.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20663041$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moreira, Eduardo L.G.</creatorcontrib><creatorcontrib>Rial, Daniel</creatorcontrib><creatorcontrib>Duarte, Filipe S.</creatorcontrib><creatorcontrib>De Carvalho, Cristiane Ribeiro</creatorcontrib><creatorcontrib>Horst, Heros</creatorcontrib><creatorcontrib>Pizzolatti, Moacir G.</creatorcontrib><creatorcontrib>Prediger, Rui D.S.</creatorcontrib><creatorcontrib>Ribeiro-do-Valle, Rosa Maria</creatorcontrib><title>Central nervous system activity of the proanthocyanidin-rich fraction obtained from Croton celtidifolius in rats</title><title>Journal of pharmacy and pharmacology</title><addtitle>J Pharm Pharmacol</addtitle><description>Objectives The aim of the present study was to evaluate the possible neurobehavioural effects in rats of the proanthocyanidin‐rich fraction (PRF) isolated from the bark of Croton celtidifolius (Euphorbiaceae).
Methods Adult Wistar rats were treated with the PRF (0.3–30 mg/kg) and evaluated in different behavioural paradigms classically used for the screening of drugs with psychoactive effects.
Key findings Acute intraperitoneal (i.p.) administration of PRF decreased spontaneous locomotor activity (open field arena and activity cage), enhanced the duration of ethyl ether‐induced hypnosis, increased the latency to the first convulsion induced by pentylenetetrazole (60 mg/kg, i.p.) and attenuated apomorphine‐induced (0.5 mg/kg, i.p.) stereotyped behaviour. In lower doses, PRF (0.3 or 3 mg/kg, i.p.) increased the frequency of open arm entries in the elevated plus‐maze test.
Conclusions The present findings suggest that the systemic administration of PRF induces a wide spectrum of behavioural alterations in rats, consistent with the putative existence of hypnosedative, anticonvulsant and anxiolytic compounds.</description><subject>Anesthetics, Inhalation - pharmacology</subject><subject>Animals</subject><subject>Anti-Anxiety Agents - pharmacology</subject><subject>Anticonvulsants - pharmacology</subject><subject>Antipsychotic Agents - pharmacology</subject><subject>Apomorphine - pharmacology</subject><subject>Behavior, Animal - drug effects</subject><subject>behaviour</subject><subject>catechin</subject><subject>central actions</subject><subject>Central Nervous System Agents - administration & dosage</subject><subject>Central Nervous System Agents - isolation & purification</subject><subject>Central Nervous System Agents - pharmacology</subject><subject>Consciousness - drug effects</subject><subject>Croton - chemistry</subject><subject>Croton celtidifolius</subject><subject>Disease Models, Animal</subject><subject>Dose-Response Relationship, Drug</subject><subject>Ether - pharmacology</subject><subject>Hypnotics and Sedatives - pharmacology</subject><subject>Injections, Intraperitoneal</subject><subject>Male</subject><subject>Motor Activity - drug effects</subject><subject>Pentylenetetrazole</subject><subject>Plant Bark</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - pharmacology</subject><subject>proanthocyanidin</subject><subject>Proanthocyanidins - administration & dosage</subject><subject>Proanthocyanidins - isolation & purification</subject><subject>Proanthocyanidins - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Seizures - chemically induced</subject><subject>Seizures - prevention & control</subject><subject>Stereotyped Behavior - drug effects</subject><issn>0022-3573</issn><issn>2042-7158</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1uGyEUhVHUKnHTvkLErqtxGX4GZhMptRKnVtRYUaNI3SA8AzLODLiAE8_bh6lTr8uGq8O5H5cDALBE0zKvb5spRhQXvGQiV1lFZYnpdH8CJseDD2CCEMYFYZycgU8xbhBCvKqqU3CGUVURRMsJ2M60S0F10Onw4ncRxiEm3UPVJPti0wC9gWmt4TZ45dLaN4NytrWuCLZZQxNGn3fQr5KyTrdZ8T2cBZ-y2OguZa_xnc1g62BQKX4GH43qov7yvp-Dx5vrX7Pb4u5-_mN2dVc0lHFaGEJoxQVjgnDODK-VEK1aMVohgkltDGtWyGBFCdYIMWoagQ2rdUuw0RlAzsHXAzdP_menY5K9jXmiTjmd3yk5FTUpSS2yUxycTfAxBm3kNthehUGWSI5xy40cU5VjqnKMW_6NW-5z68X7JbtVr9tj4798s-HyYHi1nR7-GywXy9vlWGZAcQDY_C37I0CFZ1lxwpl8-jmXv-fk-8Ni8SCX5A03CZ8y</recordid><startdate>201008</startdate><enddate>201008</enddate><creator>Moreira, Eduardo L.G.</creator><creator>Rial, Daniel</creator><creator>Duarte, Filipe S.</creator><creator>De Carvalho, Cristiane Ribeiro</creator><creator>Horst, Heros</creator><creator>Pizzolatti, Moacir G.</creator><creator>Prediger, Rui D.S.</creator><creator>Ribeiro-do-Valle, Rosa Maria</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201008</creationdate><title>Central nervous system activity of the proanthocyanidin-rich fraction obtained from Croton celtidifolius in rats</title><author>Moreira, Eduardo L.G. ; Rial, Daniel ; Duarte, Filipe S. ; De Carvalho, Cristiane Ribeiro ; Horst, Heros ; Pizzolatti, Moacir G. ; Prediger, Rui D.S. ; Ribeiro-do-Valle, Rosa Maria</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4574-f3346785583775f79a88dab54603239ff5cb0f2a432e0054fc82f59ed32fe5743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Anesthetics, Inhalation - pharmacology</topic><topic>Animals</topic><topic>Anti-Anxiety Agents - pharmacology</topic><topic>Anticonvulsants - pharmacology</topic><topic>Antipsychotic Agents - pharmacology</topic><topic>Apomorphine - pharmacology</topic><topic>Behavior, Animal - drug effects</topic><topic>behaviour</topic><topic>catechin</topic><topic>central actions</topic><topic>Central Nervous System Agents - administration & dosage</topic><topic>Central Nervous System Agents - isolation & purification</topic><topic>Central Nervous System Agents - pharmacology</topic><topic>Consciousness - drug effects</topic><topic>Croton - chemistry</topic><topic>Croton celtidifolius</topic><topic>Disease Models, Animal</topic><topic>Dose-Response Relationship, Drug</topic><topic>Ether - pharmacology</topic><topic>Hypnotics and Sedatives - pharmacology</topic><topic>Injections, Intraperitoneal</topic><topic>Male</topic><topic>Motor Activity - drug effects</topic><topic>Pentylenetetrazole</topic><topic>Plant Bark</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plant Extracts - pharmacology</topic><topic>proanthocyanidin</topic><topic>Proanthocyanidins - administration & dosage</topic><topic>Proanthocyanidins - isolation & purification</topic><topic>Proanthocyanidins - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Seizures - chemically induced</topic><topic>Seizures - prevention & control</topic><topic>Stereotyped Behavior - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moreira, Eduardo L.G.</creatorcontrib><creatorcontrib>Rial, Daniel</creatorcontrib><creatorcontrib>Duarte, Filipe S.</creatorcontrib><creatorcontrib>De Carvalho, Cristiane Ribeiro</creatorcontrib><creatorcontrib>Horst, Heros</creatorcontrib><creatorcontrib>Pizzolatti, Moacir G.</creatorcontrib><creatorcontrib>Prediger, Rui D.S.</creatorcontrib><creatorcontrib>Ribeiro-do-Valle, Rosa Maria</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmacy and pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moreira, Eduardo L.G.</au><au>Rial, Daniel</au><au>Duarte, Filipe S.</au><au>De Carvalho, Cristiane Ribeiro</au><au>Horst, Heros</au><au>Pizzolatti, Moacir G.</au><au>Prediger, Rui D.S.</au><au>Ribeiro-do-Valle, Rosa Maria</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Central nervous system activity of the proanthocyanidin-rich fraction obtained from Croton celtidifolius in rats</atitle><jtitle>Journal of pharmacy and pharmacology</jtitle><addtitle>J Pharm Pharmacol</addtitle><date>2010-08</date><risdate>2010</risdate><volume>62</volume><issue>8</issue><spage>1061</spage><epage>1068</epage><pages>1061-1068</pages><issn>0022-3573</issn><eissn>2042-7158</eissn><abstract>Objectives The aim of the present study was to evaluate the possible neurobehavioural effects in rats of the proanthocyanidin‐rich fraction (PRF) isolated from the bark of Croton celtidifolius (Euphorbiaceae).
Methods Adult Wistar rats were treated with the PRF (0.3–30 mg/kg) and evaluated in different behavioural paradigms classically used for the screening of drugs with psychoactive effects.
Key findings Acute intraperitoneal (i.p.) administration of PRF decreased spontaneous locomotor activity (open field arena and activity cage), enhanced the duration of ethyl ether‐induced hypnosis, increased the latency to the first convulsion induced by pentylenetetrazole (60 mg/kg, i.p.) and attenuated apomorphine‐induced (0.5 mg/kg, i.p.) stereotyped behaviour. In lower doses, PRF (0.3 or 3 mg/kg, i.p.) increased the frequency of open arm entries in the elevated plus‐maze test.
Conclusions The present findings suggest that the systemic administration of PRF induces a wide spectrum of behavioural alterations in rats, consistent with the putative existence of hypnosedative, anticonvulsant and anxiolytic compounds.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>20663041</pmid><doi>10.1111/j.2042-7158.2010.01124.x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Anesthetics, Inhalation - pharmacology Animals Anti-Anxiety Agents - pharmacology Anticonvulsants - pharmacology Antipsychotic Agents - pharmacology Apomorphine - pharmacology Behavior, Animal - drug effects behaviour catechin central actions Central Nervous System Agents - administration & dosage Central Nervous System Agents - isolation & purification Central Nervous System Agents - pharmacology Consciousness - drug effects Croton - chemistry Croton celtidifolius Disease Models, Animal Dose-Response Relationship, Drug Ether - pharmacology Hypnotics and Sedatives - pharmacology Injections, Intraperitoneal Male Motor Activity - drug effects Pentylenetetrazole Plant Bark Plant Extracts - administration & dosage Plant Extracts - pharmacology proanthocyanidin Proanthocyanidins - administration & dosage Proanthocyanidins - isolation & purification Proanthocyanidins - pharmacology Rats Rats, Wistar Seizures - chemically induced Seizures - prevention & control Stereotyped Behavior - drug effects |
| title | Central nervous system activity of the proanthocyanidin-rich fraction obtained from Croton celtidifolius in rats |
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