A validated stability-indicating HPLC method for the determination of PEGylated puerarin in aqueous solutions

The aim of this study was to develop a validated specific stability-indicating HPLC method for the quantitative determination of PEGylated puerarin (PEG-PUE) in aqueous solutions. The method was validated by subjecting PEG-PUE to forced degradation under stress conditions of acid, alkali, water hydr...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2010-08, Vol.878 (23), p.2061-2066
Hauptverfasser:	Liu, Xinyi, Yu, Boyang, Wang, Naijie, Zhang, Bei, Du, Feng, He, Cheng, Ye, Zuguang
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetonitrile Acids - chemistry Alkalies - chemistry Analysis Analytical, structural and metabolic biochemistry Aqueous solutions Biological and medical sciences Chromatography, High Pressure Liquid - methods Degradation Degradation kinetics Drug Stability Elution Flow rate Fundamental and applied biological sciences. Psychology General pharmacology Hydrogen-Ion Concentration Hydrolysis Isoflavones - analysis Isoflavones - chemistry Kinetics Limit of Detection Medical sciences Oxidation-Reduction PEGylated puerarin Pharmacology. Drug treatments Polyethylene Glycols - analysis Polyethylene Glycols - chemistry Reference Standards Regression Reproducibility of Results Solutions Stability-indicating reversed phase HPLC Stress degradation studies Time Factors Water - chemistry Wavelengths
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