Backbone Flexibility Controls the Activity and Specificity of a Protein−Protein Interface: Specificity in Snake Venom Metalloproteases

Protein−protein interfaces have crucial functions in many biological processes. The large interaction areas of such interfaces show complex interaction motifs. Even more challenging is the understanding of (multi)specificity in protein−protein binding. Many proteins can bind several partners to medi...

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Veröffentlicht in:	Journal of the American Chemical Society 2010-08, Vol.132 (30), p.10330-10337
Hauptverfasser:	Wallnoefer, Hannes G, Lingott, Torsten, Gutiérrez, José María, Merfort, Irmgard, Liedl, Klaus R
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Crystallography, X-Ray Metalloproteases - chemistry Metalloproteases - metabolism Molecular Dynamics Simulation Molecular Sequence Data Protein Binding Protein Conformation Sequence Alignment Snake Venoms - chemistry Snake Venoms - metabolism Snakes - metabolism
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