ABO blood group alleles: A risk factor for coronary artery disease. An angiographic study
Abstract Objectives To analyze the impact of ABO groups on coronary heart disease risk factors, coronary involvement and prognosis. Methods An observational single center study was conducted to examine 4901 consecutive patients with heart disease receiving coronary angiography and ABO group determin...
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| Veröffentlicht in: | Atherosclerosis 2010-08, Vol.211 (2), p.461-466 |
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| creator | Carpeggiani, Clara Coceani, Michele Landi, Patrizia Michelassi, Claudio L’Abbate, Antonio |
| description | Abstract Objectives To analyze the impact of ABO groups on coronary heart disease risk factors, coronary involvement and prognosis. Methods An observational single center study was conducted to examine 4901 consecutive patients with heart disease receiving coronary angiography and ABO group determination at National Research Council Institute of Clinical Physiology between January 1993 and December 2003, with maximum 10 years follow-up. All-cause death and cardiac death, were the considered end points. Results When compared to the official distribution of ABO groups in the Italian population (O 40%, A 36%, B 17%, AB 7%), a substantially different distribution was observed in the study population (O 43.3%, A 41.4%, B 11.2%, AB 4.1%). In addition, a significant association was found between group non-O and family history of ischemic heart disease, hypercholesterolemia and presence of coronary atherosclerosis. Higher prevalence of A and B alleles was found in patients with myocardial infarction ( P < 0.05). Group non-O was a powerful predictor of cardiac mortality in patients aged |
| doi_str_mv | 10.1016/j.atherosclerosis.2010.03.012 |
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An angiographic study</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Carpeggiani, Clara ; Coceani, Michele ; Landi, Patrizia ; Michelassi, Claudio ; L’Abbate, Antonio</creator><creatorcontrib>Carpeggiani, Clara ; Coceani, Michele ; Landi, Patrizia ; Michelassi, Claudio ; L’Abbate, Antonio</creatorcontrib><description>Abstract Objectives To analyze the impact of ABO groups on coronary heart disease risk factors, coronary involvement and prognosis. Methods An observational single center study was conducted to examine 4901 consecutive patients with heart disease receiving coronary angiography and ABO group determination at National Research Council Institute of Clinical Physiology between January 1993 and December 2003, with maximum 10 years follow-up. All-cause death and cardiac death, were the considered end points. Results When compared to the official distribution of ABO groups in the Italian population (O 40%, A 36%, B 17%, AB 7%), a substantially different distribution was observed in the study population (O 43.3%, A 41.4%, B 11.2%, AB 4.1%). In addition, a significant association was found between group non-O and family history of ischemic heart disease, hypercholesterolemia and presence of coronary atherosclerosis. Higher prevalence of A and B alleles was found in patients with myocardial infarction ( P < 0.05). Group non-O was a powerful predictor of cardiac mortality in patients aged <65 years, particularly in women (HR 1.53, 95% CI 1.06–2.21 and HR 5.29, 95% CI 1.57–17.82, respectively). Conclusions Group non-O is associated with increased mortality in patients with ischemic heart disease. Group non-O increases the risk for cardiac death in non-elderly patients, particularly in younger females, and groups A and B prevail in myocardial infarction. ABO group determination might aid in genetic screening for ischemic heart disease and become relevant in the management of risk factor control.</description><identifier>ISSN: 0021-9150</identifier><identifier>EISSN: 1879-1484</identifier><identifier>DOI: 10.1016/j.atherosclerosis.2010.03.012</identifier><identifier>PMID: 20371059</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ireland Ltd</publisher><subject>ABO Blood-Group System ; ABO groups ; Age Factors ; Aged ; Alleles ; Angiography - methods ; Atherosclerosis ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Cardiovascular ; Coronary Angiography - methods ; Coronary Artery Disease - blood ; Coronary Artery Disease - diagnosis ; Coronary Artery Disease - genetics ; Coronary atherosclerosis ; Coronary heart disease ; Female ; Follow-Up Studies ; Heart ; Humans ; Italy ; Male ; Medical sciences ; Middle Aged ; Prognosis ; Risk Factors ; Sex Factors</subject><ispartof>Atherosclerosis, 2010-08, Vol.211 (2), p.461-466</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2010 Elsevier Ireland Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2010 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c539t-58c25bbe5a267d6e3e562ec6d9f1a690b4af630e966cf48c37b083e6b3695a3d3</citedby><cites>FETCH-LOGICAL-c539t-58c25bbe5a267d6e3e562ec6d9f1a690b4af630e966cf48c37b083e6b3695a3d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0021915010002285$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23154579$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20371059$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carpeggiani, Clara</creatorcontrib><creatorcontrib>Coceani, Michele</creatorcontrib><creatorcontrib>Landi, Patrizia</creatorcontrib><creatorcontrib>Michelassi, Claudio</creatorcontrib><creatorcontrib>L’Abbate, Antonio</creatorcontrib><title>ABO blood group alleles: A risk factor for coronary artery disease. An angiographic study</title><title>Atherosclerosis</title><addtitle>Atherosclerosis</addtitle><description>Abstract Objectives To analyze the impact of ABO groups on coronary heart disease risk factors, coronary involvement and prognosis. Methods An observational single center study was conducted to examine 4901 consecutive patients with heart disease receiving coronary angiography and ABO group determination at National Research Council Institute of Clinical Physiology between January 1993 and December 2003, with maximum 10 years follow-up. All-cause death and cardiac death, were the considered end points. Results When compared to the official distribution of ABO groups in the Italian population (O 40%, A 36%, B 17%, AB 7%), a substantially different distribution was observed in the study population (O 43.3%, A 41.4%, B 11.2%, AB 4.1%). In addition, a significant association was found between group non-O and family history of ischemic heart disease, hypercholesterolemia and presence of coronary atherosclerosis. Higher prevalence of A and B alleles was found in patients with myocardial infarction ( P < 0.05). Group non-O was a powerful predictor of cardiac mortality in patients aged <65 years, particularly in women (HR 1.53, 95% CI 1.06–2.21 and HR 5.29, 95% CI 1.57–17.82, respectively). Conclusions Group non-O is associated with increased mortality in patients with ischemic heart disease. Group non-O increases the risk for cardiac death in non-elderly patients, particularly in younger females, and groups A and B prevail in myocardial infarction. ABO group determination might aid in genetic screening for ischemic heart disease and become relevant in the management of risk factor control.</description><subject>ABO Blood-Group System</subject><subject>ABO groups</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Alleles</subject><subject>Angiography - methods</subject><subject>Atherosclerosis</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular</subject><subject>Coronary Angiography - methods</subject><subject>Coronary Artery Disease - blood</subject><subject>Coronary Artery Disease - diagnosis</subject><subject>Coronary Artery Disease - genetics</subject><subject>Coronary atherosclerosis</subject><subject>Coronary heart disease</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Heart</subject><subject>Humans</subject><subject>Italy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Prognosis</subject><subject>Risk Factors</subject><subject>Sex Factors</subject><issn>0021-9150</issn><issn>1879-1484</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkstu1DAUQC0EokPhF5A3FasEP2InRgJpWtGCVKkLYMHKcuybqaeeeLATpPl7HM20i65Y2Hfhcx8-ughdUFJTQuXHbW2me0gx27DcPteMlDfCa0LZC7SiXasq2nTNS7QihNFKUUHO0Juct4SQpqXda3TGCG8pEWqFfq8v73AfYnR4k-K8xyYECJA_4TVOPj_gwdgpJjyUY2OKo0kHbNIEJTifwWSo8XrEZtz4uElmf-8tztPsDm_Rq8GEDO9O8Rz9uv768-pbdXt38_1qfVtZwdVUic4y0fcgDJOtk8BBSAZWOjVQIxXpGzNITkBJaYems7ztScdB9lwqYbjj5-jDse4-xT8z5EnvfLYQghkhzlm3TaeYkqIt5OcjaYu4nGDQ--R35UOaEr3I1Vv9TK5e5GrCdZFb8t-fOs39DtxT9qPNAlycAJOtCUMyoy01njhORSPahbs5clC8_PWQdLYeRgvOJ7CTdtH_90hfnlWywY--NH-AA-RtnNNY5GuqM9NE_1g2YlkIWnaBsU7wf0HOtqM</recordid><startdate>20100801</startdate><enddate>20100801</enddate><creator>Carpeggiani, Clara</creator><creator>Coceani, Michele</creator><creator>Landi, Patrizia</creator><creator>Michelassi, Claudio</creator><creator>L’Abbate, Antonio</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100801</creationdate><title>ABO blood group alleles: A risk factor for coronary artery disease. An angiographic study</title><author>Carpeggiani, Clara ; Coceani, Michele ; Landi, Patrizia ; Michelassi, Claudio ; L’Abbate, Antonio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c539t-58c25bbe5a267d6e3e562ec6d9f1a690b4af630e966cf48c37b083e6b3695a3d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>ABO Blood-Group System</topic><topic>ABO groups</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Alleles</topic><topic>Angiography - methods</topic><topic>Atherosclerosis</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular</topic><topic>Coronary Angiography - methods</topic><topic>Coronary Artery Disease - blood</topic><topic>Coronary Artery Disease - diagnosis</topic><topic>Coronary Artery Disease - genetics</topic><topic>Coronary atherosclerosis</topic><topic>Coronary heart disease</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Heart</topic><topic>Humans</topic><topic>Italy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Prognosis</topic><topic>Risk Factors</topic><topic>Sex Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carpeggiani, Clara</creatorcontrib><creatorcontrib>Coceani, Michele</creatorcontrib><creatorcontrib>Landi, Patrizia</creatorcontrib><creatorcontrib>Michelassi, Claudio</creatorcontrib><creatorcontrib>L’Abbate, Antonio</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Atherosclerosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carpeggiani, Clara</au><au>Coceani, Michele</au><au>Landi, Patrizia</au><au>Michelassi, Claudio</au><au>L’Abbate, Antonio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ABO blood group alleles: A risk factor for coronary artery disease. An angiographic study</atitle><jtitle>Atherosclerosis</jtitle><addtitle>Atherosclerosis</addtitle><date>2010-08-01</date><risdate>2010</risdate><volume>211</volume><issue>2</issue><spage>461</spage><epage>466</epage><pages>461-466</pages><issn>0021-9150</issn><eissn>1879-1484</eissn><abstract>Abstract Objectives To analyze the impact of ABO groups on coronary heart disease risk factors, coronary involvement and prognosis. Methods An observational single center study was conducted to examine 4901 consecutive patients with heart disease receiving coronary angiography and ABO group determination at National Research Council Institute of Clinical Physiology between January 1993 and December 2003, with maximum 10 years follow-up. All-cause death and cardiac death, were the considered end points. Results When compared to the official distribution of ABO groups in the Italian population (O 40%, A 36%, B 17%, AB 7%), a substantially different distribution was observed in the study population (O 43.3%, A 41.4%, B 11.2%, AB 4.1%). In addition, a significant association was found between group non-O and family history of ischemic heart disease, hypercholesterolemia and presence of coronary atherosclerosis. Higher prevalence of A and B alleles was found in patients with myocardial infarction ( P < 0.05). Group non-O was a powerful predictor of cardiac mortality in patients aged <65 years, particularly in women (HR 1.53, 95% CI 1.06–2.21 and HR 5.29, 95% CI 1.57–17.82, respectively). Conclusions Group non-O is associated with increased mortality in patients with ischemic heart disease. Group non-O increases the risk for cardiac death in non-elderly patients, particularly in younger females, and groups A and B prevail in myocardial infarction. ABO group determination might aid in genetic screening for ischemic heart disease and become relevant in the management of risk factor control.</abstract><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>20371059</pmid><doi>10.1016/j.atherosclerosis.2010.03.012</doi><tpages>6</tpages></addata></record> |
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| subjects | ABO Blood-Group System ABO groups Age Factors Aged Alleles Angiography - methods Atherosclerosis Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular Coronary Angiography - methods Coronary Artery Disease - blood Coronary Artery Disease - diagnosis Coronary Artery Disease - genetics Coronary atherosclerosis Coronary heart disease Female Follow-Up Studies Heart Humans Italy Male Medical sciences Middle Aged Prognosis Risk Factors Sex Factors |
| title | ABO blood group alleles: A risk factor for coronary artery disease. An angiographic study |
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