Single-File Diffusion of Protein Drugs through Cylindrical Nanochannels
A new drug delivery device using cylindrical block copolymer nanochannels was successfully developed for controlled protein drug delivery applications. Depending on the hydrodynamic diameter of the protein drugs, the pore size in cylindrical nanochannels could be controlled precisely down to 6 nm by...
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| Veröffentlicht in: | ACS nano 2010-07, Vol.4 (7), p.3817-3822 |
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| container_end_page | 3822 |
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| container_title | ACS nano |
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| creator | Yang, Seung Yun Yang, Jeong-A Kim, Eung-Sam Jeon, Gumhye Oh, Eun Ju Choi, Kwan Yong Hahn, Sei Kwang Kim, Jin Kon |
| description | A new drug delivery device using cylindrical block copolymer nanochannels was successfully developed for controlled protein drug delivery applications. Depending on the hydrodynamic diameter of the protein drugs, the pore size in cylindrical nanochannels could be controlled precisely down to 6 nm by Au deposition. Zero-order release of bovine serum albumin (BSA) and human growth hormone (hGH) by single-file diffusion, which has been observed for gas diffusion through zeolite pores, was realized up to 2 months without protein denaturation. Furthermore, a nearly constant in vivo release of hGH from the drug delivery nanodevice implanted to Sprague−Dawley (SD) rats was continued up to 3 weeks, demonstrating the feasibility for long-term controlled delivery of therapeutic protein drugs. |
| doi_str_mv | 10.1021/nn100464u |
| format | Article |
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Depending on the hydrodynamic diameter of the protein drugs, the pore size in cylindrical nanochannels could be controlled precisely down to 6 nm by Au deposition. Zero-order release of bovine serum albumin (BSA) and human growth hormone (hGH) by single-file diffusion, which has been observed for gas diffusion through zeolite pores, was realized up to 2 months without protein denaturation. Furthermore, a nearly constant in vivo release of hGH from the drug delivery nanodevice implanted to Sprague−Dawley (SD) rats was continued up to 3 weeks, demonstrating the feasibility for long-term controlled delivery of therapeutic protein drugs.</description><subject>Animals</subject><subject>Cattle</subject><subject>Diffusion</subject><subject>Drug Delivery Systems - methods</subject><subject>Gold - chemistry</subject><subject>Human Growth Hormone - administration & dosage</subject><subject>Human Growth Hormone - chemistry</subject><subject>Human Growth Hormone - pharmacokinetics</subject><subject>Humans</subject><subject>Injections</subject><subject>Membranes, Artificial</subject><subject>Nanostructures - chemistry</subject><subject>Pharmaceutical Preparations - chemistry</subject><subject>Polymethyl Methacrylate - chemistry</subject><subject>Polystyrenes - chemistry</subject><subject>Porosity</subject><subject>Proteins - chemistry</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Serum Albumin, Bovine - chemistry</subject><issn>1936-0851</issn><issn>1936-086X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkE1LAzEQQIMotlYP_gHZi4iH1SS7SXaP0toqFBVU8LZk89GmpElNNof-e1dae_I0M_B4MA-ASwTvEMTo3jkEYUnLdASGqC5oDiv6dXzYCRqAsxhXEBJWMXoKBhgSyBAjQzB7N25hVT41VmUTo3WKxrvM6-wt-E4Zl01CWsSsWwafFstsvLXGyWAEt9kLd14suXPKxnNwormN6mI_R-Bz-vgxfsrnr7Pn8cM850UFuxwzLRSjtNCKtTWFpK6lZKrEtBCwlQxhijUVBBHNiShhiYv-IpJJgkkrVTECNzvvJvjvpGLXrE0UylrulE-xYWVV4xpD2pO3O1IEH2NQutkEs-Zh2yDY_GZrDtl69mpvTe1ayQP516kHrncAF7FZ-RRc_-Q_oh-ZRnOI</recordid><startdate>20100727</startdate><enddate>20100727</enddate><creator>Yang, Seung Yun</creator><creator>Yang, Jeong-A</creator><creator>Kim, Eung-Sam</creator><creator>Jeon, Gumhye</creator><creator>Oh, Eun Ju</creator><creator>Choi, Kwan Yong</creator><creator>Hahn, Sei Kwang</creator><creator>Kim, Jin Kon</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100727</creationdate><title>Single-File Diffusion of Protein Drugs through Cylindrical Nanochannels</title><author>Yang, Seung Yun ; Yang, Jeong-A ; Kim, Eung-Sam ; Jeon, Gumhye ; Oh, Eun Ju ; Choi, Kwan Yong ; Hahn, Sei Kwang ; Kim, Jin Kon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a380t-27fce7663fe7b960599dd7e4263c0bd71262f6c515fa5c404236c55d7d525bde3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Cattle</topic><topic>Diffusion</topic><topic>Drug Delivery Systems - methods</topic><topic>Gold - chemistry</topic><topic>Human Growth Hormone - administration & dosage</topic><topic>Human Growth Hormone - chemistry</topic><topic>Human Growth Hormone - pharmacokinetics</topic><topic>Humans</topic><topic>Injections</topic><topic>Membranes, Artificial</topic><topic>Nanostructures - chemistry</topic><topic>Pharmaceutical Preparations - chemistry</topic><topic>Polymethyl Methacrylate - chemistry</topic><topic>Polystyrenes - chemistry</topic><topic>Porosity</topic><topic>Proteins - chemistry</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Serum Albumin, Bovine - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Seung Yun</creatorcontrib><creatorcontrib>Yang, Jeong-A</creatorcontrib><creatorcontrib>Kim, Eung-Sam</creatorcontrib><creatorcontrib>Jeon, Gumhye</creatorcontrib><creatorcontrib>Oh, Eun Ju</creatorcontrib><creatorcontrib>Choi, Kwan Yong</creatorcontrib><creatorcontrib>Hahn, Sei Kwang</creatorcontrib><creatorcontrib>Kim, Jin Kon</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>ACS nano</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Seung Yun</au><au>Yang, Jeong-A</au><au>Kim, Eung-Sam</au><au>Jeon, Gumhye</au><au>Oh, Eun Ju</au><au>Choi, Kwan Yong</au><au>Hahn, Sei Kwang</au><au>Kim, Jin Kon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Single-File Diffusion of Protein Drugs through Cylindrical Nanochannels</atitle><jtitle>ACS nano</jtitle><addtitle>ACS Nano</addtitle><date>2010-07-27</date><risdate>2010</risdate><volume>4</volume><issue>7</issue><spage>3817</spage><epage>3822</epage><pages>3817-3822</pages><issn>1936-0851</issn><eissn>1936-086X</eissn><abstract>A new drug delivery device using cylindrical block copolymer nanochannels was successfully developed for controlled protein drug delivery applications. 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| subjects | Animals Cattle Diffusion Drug Delivery Systems - methods Gold - chemistry Human Growth Hormone - administration & dosage Human Growth Hormone - chemistry Human Growth Hormone - pharmacokinetics Humans Injections Membranes, Artificial Nanostructures - chemistry Pharmaceutical Preparations - chemistry Polymethyl Methacrylate - chemistry Polystyrenes - chemistry Porosity Proteins - chemistry Rats Rats, Sprague-Dawley Serum Albumin, Bovine - chemistry |
| title | Single-File Diffusion of Protein Drugs through Cylindrical Nanochannels |
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