Biomimetic Synthesis of Polycyclic Polyprenylated Acylphloroglucinol Natural Products Isolated from Hypericum papuanum

Biomimetic syntheses of three polycylic polyprenylated acylphloroglucinol natural products isolated from Hypericum papuanum, ialibinone A, ialibinone B, and hyperguinone B, have been accomplished by selective oxidative cyclizations of the proposed biosynthetic precursor 5, which was synthesized from...

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Veröffentlicht in:	Organic letters 2010-08, Vol.12 (15), p.3532-3535
Hauptverfasser:	George, Jonathan H, Hesse, Micha D, Baldwin, Jack E, Adlington, Robert M
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Products - chemical synthesis Biological Products - chemistry Biological Products - isolation & purification Cyclization Hypericum - chemistry Molecular Structure Oxidation-Reduction Phloroglucinol - analogs & derivatives Phloroglucinol - chemistry Polycyclic Aromatic Hydrocarbons - chemical synthesis Polycyclic Aromatic Hydrocarbons - chemistry Polycyclic Aromatic Hydrocarbons - isolation & purification
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Zusammenfassung:	Biomimetic syntheses of three polycylic polyprenylated acylphloroglucinol natural products isolated from Hypericum papuanum, ialibinone A, ialibinone B, and hyperguinone B, have been accomplished by selective oxidative cyclizations of the proposed biosynthetic precursor 5, which was synthesized from phloroglucinol in three steps.
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol101380a