[ 3H] corticosterone binding activity of adrenal incubation media in response to in vivo and in vitro ACTH stimulation
The influence of in vivo or in vitro administration of ACTH upon in vitro adrenal corticosterone production as well as [ 3H] corticosterone binding activity of incubation media have been examined. ACTH, regardless of the route of administration, significantly elevated corticosterone during an initia...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1979-10, Vol.90 (4), p.1355-1363 |
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| container_title | Biochemical and biophysical research communications |
| container_volume | 90 |
| creator | Pritchett, J.F. Harper, W.L. Marple, D.N. Bradley, J.T. Till, M.L. |
| description | The influence of
in vivo or
in vitro administration of ACTH upon
in vitro adrenal corticosterone production as well as [
3H] corticosterone binding activity of incubation media have been examined. ACTH, regardless of the route of administration, significantly elevated corticosterone during an initial incubation period. During initial incubation periods ACTH also elevated [
3H] corticosterone binding activity of the incubation media. Ensuing incubations were characterized by either a marked decline in binding activity (
in vivo ACTH administration) or a marked decline with an attendant negative correlation between binding activity and ACTH level. Corticosteroidogenic response to ACTH remained intact during ensuing incubations. The data suggest the existence of an ACTH-sensitive intraglandular corticosterone binding ligand(s), the activity or concentration of which is dramatically altered by incubation protocol and time of sacrifice. |
| doi_str_mv | 10.1016/0006-291X(79)91185-9 |
| format | Article |
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in vivo or
in vitro administration of ACTH upon
in vitro adrenal corticosterone production as well as [
3H] corticosterone binding activity of incubation media have been examined. ACTH, regardless of the route of administration, significantly elevated corticosterone during an initial incubation period. During initial incubation periods ACTH also elevated [
3H] corticosterone binding activity of the incubation media. Ensuing incubations were characterized by either a marked decline in binding activity (
in vivo ACTH administration) or a marked decline with an attendant negative correlation between binding activity and ACTH level. Corticosteroidogenic response to ACTH remained intact during ensuing incubations. The data suggest the existence of an ACTH-sensitive intraglandular corticosterone binding ligand(s), the activity or concentration of which is dramatically altered by incubation protocol and time of sacrifice.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/0006-291X(79)91185-9</identifier><identifier>PMID: 229836</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adrenal Glands - drug effects ; Adrenal Glands - metabolism ; Adrenocorticotropic Hormone - pharmacology ; Animals ; Corticosterone - metabolism ; Dose-Response Relationship, Drug ; Kinetics ; Male ; Rats ; Receptors, Glucocorticoid - drug effects ; Receptors, Glucocorticoid - metabolism ; Receptors, Steroid - metabolism</subject><ispartof>Biochemical and biophysical research communications, 1979-10, Vol.90 (4), p.1355-1363</ispartof><rights>1979 Academic Press, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c271t-20b005d1c96d6df428f35f1f1f065229bb99604249b929a6342c100fa82038bc3</citedby><cites>FETCH-LOGICAL-c271t-20b005d1c96d6df428f35f1f1f065229bb99604249b929a6342c100fa82038bc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-291X(79)91185-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/229836$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pritchett, J.F.</creatorcontrib><creatorcontrib>Harper, W.L.</creatorcontrib><creatorcontrib>Marple, D.N.</creatorcontrib><creatorcontrib>Bradley, J.T.</creatorcontrib><creatorcontrib>Till, M.L.</creatorcontrib><title>[ 3H] corticosterone binding activity of adrenal incubation media in response to in vivo and in vitro ACTH stimulation</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>The influence of
in vivo or
in vitro administration of ACTH upon
in vitro adrenal corticosterone production as well as [
3H] corticosterone binding activity of incubation media have been examined. ACTH, regardless of the route of administration, significantly elevated corticosterone during an initial incubation period. During initial incubation periods ACTH also elevated [
3H] corticosterone binding activity of the incubation media. Ensuing incubations were characterized by either a marked decline in binding activity (
in vivo ACTH administration) or a marked decline with an attendant negative correlation between binding activity and ACTH level. Corticosteroidogenic response to ACTH remained intact during ensuing incubations. The data suggest the existence of an ACTH-sensitive intraglandular corticosterone binding ligand(s), the activity or concentration of which is dramatically altered by incubation protocol and time of sacrifice.</description><subject>Adrenal Glands - drug effects</subject><subject>Adrenal Glands - metabolism</subject><subject>Adrenocorticotropic Hormone - pharmacology</subject><subject>Animals</subject><subject>Corticosterone - metabolism</subject><subject>Dose-Response Relationship, Drug</subject><subject>Kinetics</subject><subject>Male</subject><subject>Rats</subject><subject>Receptors, Glucocorticoid - drug effects</subject><subject>Receptors, Glucocorticoid - metabolism</subject><subject>Receptors, Steroid - metabolism</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9LJDEQxYOsuuOfb-AhJ3EPrVXp7kznIsigOwuCFwVBJKTT6SVLTzIm6Qa_vRlbPC51SFXqvQf1I-QM4RIB-RUA8IIJfL5Yil8CsakLsUcWCAIKhlD9IItvyU9yFOM_AMSKi0NywJhoSr4g0wst169U-5Cs9jGZ4J2hrXWddX-p0slONr1T31PVBePUQK3TY6uS9Y5uTGdV_qDBxK130dDkd-NkJ0-V6-Y-BU9vVo9rGpPdjMOn9YTs92qI5vTrPSZPd7ePq3Vx__D7z-rmvtBsialg0ALUHWrBO971FWv6su4xF_A6n9C2QnCoWCVawYTiZcU0AvSqYVA2rS6Pyfmcuw3-bTQxyY2N2gyDcsaPUS6rRiCvMQurWaiDjzGYXm6D3ajwLhHkjrbcoZQ7lHIp5CdtKbLt7Ct_bDONb9OMN6-v57XJN07WBBm1NU5nbsHoJDtv_5__AQxIjsw</recordid><startdate>19791029</startdate><enddate>19791029</enddate><creator>Pritchett, J.F.</creator><creator>Harper, W.L.</creator><creator>Marple, D.N.</creator><creator>Bradley, J.T.</creator><creator>Till, M.L.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19791029</creationdate><title>[ 3H] corticosterone binding activity of adrenal incubation media in response to in vivo and in vitro ACTH stimulation</title><author>Pritchett, J.F. ; Harper, W.L. ; Marple, D.N. ; Bradley, J.T. ; Till, M.L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c271t-20b005d1c96d6df428f35f1f1f065229bb99604249b929a6342c100fa82038bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Adrenal Glands - drug effects</topic><topic>Adrenal Glands - metabolism</topic><topic>Adrenocorticotropic Hormone - pharmacology</topic><topic>Animals</topic><topic>Corticosterone - metabolism</topic><topic>Dose-Response Relationship, Drug</topic><topic>Kinetics</topic><topic>Male</topic><topic>Rats</topic><topic>Receptors, Glucocorticoid - drug effects</topic><topic>Receptors, Glucocorticoid - metabolism</topic><topic>Receptors, Steroid - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pritchett, J.F.</creatorcontrib><creatorcontrib>Harper, W.L.</creatorcontrib><creatorcontrib>Marple, D.N.</creatorcontrib><creatorcontrib>Bradley, J.T.</creatorcontrib><creatorcontrib>Till, M.L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pritchett, J.F.</au><au>Harper, W.L.</au><au>Marple, D.N.</au><au>Bradley, J.T.</au><au>Till, M.L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>[ 3H] corticosterone binding activity of adrenal incubation media in response to in vivo and in vitro ACTH stimulation</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>1979-10-29</date><risdate>1979</risdate><volume>90</volume><issue>4</issue><spage>1355</spage><epage>1363</epage><pages>1355-1363</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>The influence of
in vivo or
in vitro administration of ACTH upon
in vitro adrenal corticosterone production as well as [
3H] corticosterone binding activity of incubation media have been examined. ACTH, regardless of the route of administration, significantly elevated corticosterone during an initial incubation period. During initial incubation periods ACTH also elevated [
3H] corticosterone binding activity of the incubation media. Ensuing incubations were characterized by either a marked decline in binding activity (
in vivo ACTH administration) or a marked decline with an attendant negative correlation between binding activity and ACTH level. Corticosteroidogenic response to ACTH remained intact during ensuing incubations. The data suggest the existence of an ACTH-sensitive intraglandular corticosterone binding ligand(s), the activity or concentration of which is dramatically altered by incubation protocol and time of sacrifice.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>229836</pmid><doi>10.1016/0006-291X(79)91185-9</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-291X |
| ispartof | Biochemical and biophysical research communications, 1979-10, Vol.90 (4), p.1355-1363 |
| issn | 0006-291X 1090-2104 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adrenal Glands - drug effects Adrenal Glands - metabolism Adrenocorticotropic Hormone - pharmacology Animals Corticosterone - metabolism Dose-Response Relationship, Drug Kinetics Male Rats Receptors, Glucocorticoid - drug effects Receptors, Glucocorticoid - metabolism Receptors, Steroid - metabolism |
| title | [ 3H] corticosterone binding activity of adrenal incubation media in response to in vivo and in vitro ACTH stimulation |
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