Metabolism of inorganic arsenic to organoarsenicals in rainbow trout ( Salmo gairdneri)
Chemical speciation of arsenic was examined by radioactive tracer and chromatographic techniques applied to muscle, liver, kidney, blood, bile, and urine from rainbow trout ( Salmo gairdneri) given an oral dose of 74As as arsenic acid. Conversion to organic forms of arsenic was rapid and extensive....
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| Veröffentlicht in: | Ecotoxicology and environmental safety 1979-01, Vol.3 (4), p.394-400 |
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| creator | Oladimeji, A.A. Qadri, S.U. Tam, G.K.H. deFreitas, A.S.W. |
| description | Chemical speciation of arsenic was examined by radioactive tracer and chromatographic techniques applied to muscle, liver, kidney, blood, bile, and urine from rainbow trout (
Salmo gairdneri) given an oral dose of
74As as arsenic acid. Conversion to organic forms of arsenic was rapid and extensive. The ratio of total organic to inorganic increased with time in all tissues, with the organic arsenic fraction accounting for about 50% at 6 hr and over 80% at 24 hr. An organoarsenic metabolite was shown by thin-layer chromatography to have the same
R
f
as ethylarsenobetaine, and this compound accounted for the major portion of the total arsenic in all tissues including bile and urine sampled 24–96 hr postdose. |
| doi_str_mv | 10.1016/0147-6513(79)90029-0 |
| format | Article |
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Salmo gairdneri) given an oral dose of
74As as arsenic acid. Conversion to organic forms of arsenic was rapid and extensive. The ratio of total organic to inorganic increased with time in all tissues, with the organic arsenic fraction accounting for about 50% at 6 hr and over 80% at 24 hr. An organoarsenic metabolite was shown by thin-layer chromatography to have the same
R
f
as ethylarsenobetaine, and this compound accounted for the major portion of the total arsenic in all tissues including bile and urine sampled 24–96 hr postdose.</description><identifier>ISSN: 0147-6513</identifier><identifier>EISSN: 1090-2414</identifier><identifier>DOI: 10.1016/0147-6513(79)90029-0</identifier><identifier>PMID: 535559</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Animals ; Arsenic - blood ; Arsenic - metabolism ; Arsenic - urine ; Bile - metabolism ; Chromatography, Ion Exchange ; Chromatography, Thin Layer ; Salmonidae - metabolism ; Time Factors ; Tissue Distribution ; Trout - metabolism</subject><ispartof>Ecotoxicology and environmental safety, 1979-01, Vol.3 (4), p.394-400</ispartof><rights>1979</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-4629f017921c022711d61b6caa19092666c5e872837ca3682985f8ae975d17803</citedby><cites>FETCH-LOGICAL-c387t-4629f017921c022711d61b6caa19092666c5e872837ca3682985f8ae975d17803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0147-6513(79)90029-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27926,27927,45997</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/535559$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oladimeji, A.A.</creatorcontrib><creatorcontrib>Qadri, S.U.</creatorcontrib><creatorcontrib>Tam, G.K.H.</creatorcontrib><creatorcontrib>deFreitas, A.S.W.</creatorcontrib><title>Metabolism of inorganic arsenic to organoarsenicals in rainbow trout ( Salmo gairdneri)</title><title>Ecotoxicology and environmental safety</title><addtitle>Ecotoxicol Environ Saf</addtitle><description>Chemical speciation of arsenic was examined by radioactive tracer and chromatographic techniques applied to muscle, liver, kidney, blood, bile, and urine from rainbow trout (
Salmo gairdneri) given an oral dose of
74As as arsenic acid. Conversion to organic forms of arsenic was rapid and extensive. The ratio of total organic to inorganic increased with time in all tissues, with the organic arsenic fraction accounting for about 50% at 6 hr and over 80% at 24 hr. An organoarsenic metabolite was shown by thin-layer chromatography to have the same
R
f
as ethylarsenobetaine, and this compound accounted for the major portion of the total arsenic in all tissues including bile and urine sampled 24–96 hr postdose.</description><subject>Animals</subject><subject>Arsenic - blood</subject><subject>Arsenic - metabolism</subject><subject>Arsenic - urine</subject><subject>Bile - metabolism</subject><subject>Chromatography, Ion Exchange</subject><subject>Chromatography, Thin Layer</subject><subject>Salmonidae - metabolism</subject><subject>Time Factors</subject><subject>Tissue Distribution</subject><subject>Trout - metabolism</subject><issn>0147-6513</issn><issn>1090-2414</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLLDEQRoNcH-PjH7jI6uIsWqvSndfmgogvUFyouAyZdFoi3R1NehT_vd3O4NK7Kvjq1EdxCDlEOEZAcQJYyUJwLI-knmsApgvYIDMEDQWrsPpDZj_IDtnN-QUASuB8m2zxknOuZ-Tp1g92EduQOxobGvqYnm0fHLUp-2kOkX5HcR3YNo8UTTb0i_hBhxSXAz2i97btIn22IdW9T2G-TzabEfUH67lHHi_OH86uipu7y-uz05vClUoORSWYbgClZuiAMYlYC1wIZy1q0EwI4bhXkqlSOlsKxbTijbJeS16jVFDukb-r3tcU35Y-D6YL2fm2tb2Py2xkpZTSKP8LYqmhQsFHsFqBLsWck2_MawqdTZ8GwUzezSTVTFKN1Obbu5keOVz3Lxedr3-OVqLH9b_V2o8y3oNPJrvge-frkLwbTB3D7_1fqQGP4w</recordid><startdate>19790101</startdate><enddate>19790101</enddate><creator>Oladimeji, A.A.</creator><creator>Qadri, S.U.</creator><creator>Tam, G.K.H.</creator><creator>deFreitas, A.S.W.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QH</scope><scope>7X8</scope></search><sort><creationdate>19790101</creationdate><title>Metabolism of inorganic arsenic to organoarsenicals in rainbow trout ( Salmo gairdneri)</title><author>Oladimeji, A.A. ; Qadri, S.U. ; Tam, G.K.H. ; deFreitas, A.S.W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-4629f017921c022711d61b6caa19092666c5e872837ca3682985f8ae975d17803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Animals</topic><topic>Arsenic - blood</topic><topic>Arsenic - metabolism</topic><topic>Arsenic - urine</topic><topic>Bile - metabolism</topic><topic>Chromatography, Ion Exchange</topic><topic>Chromatography, Thin Layer</topic><topic>Salmonidae - metabolism</topic><topic>Time Factors</topic><topic>Tissue Distribution</topic><topic>Trout - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oladimeji, A.A.</creatorcontrib><creatorcontrib>Qadri, S.U.</creatorcontrib><creatorcontrib>Tam, G.K.H.</creatorcontrib><creatorcontrib>deFreitas, A.S.W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aqualine</collection><collection>MEDLINE - Academic</collection><jtitle>Ecotoxicology and environmental safety</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oladimeji, A.A.</au><au>Qadri, S.U.</au><au>Tam, G.K.H.</au><au>deFreitas, A.S.W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolism of inorganic arsenic to organoarsenicals in rainbow trout ( Salmo gairdneri)</atitle><jtitle>Ecotoxicology and environmental safety</jtitle><addtitle>Ecotoxicol Environ Saf</addtitle><date>1979-01-01</date><risdate>1979</risdate><volume>3</volume><issue>4</issue><spage>394</spage><epage>400</epage><pages>394-400</pages><issn>0147-6513</issn><eissn>1090-2414</eissn><abstract>Chemical speciation of arsenic was examined by radioactive tracer and chromatographic techniques applied to muscle, liver, kidney, blood, bile, and urine from rainbow trout (
Salmo gairdneri) given an oral dose of
74As as arsenic acid. Conversion to organic forms of arsenic was rapid and extensive. The ratio of total organic to inorganic increased with time in all tissues, with the organic arsenic fraction accounting for about 50% at 6 hr and over 80% at 24 hr. An organoarsenic metabolite was shown by thin-layer chromatography to have the same
R
f
as ethylarsenobetaine, and this compound accounted for the major portion of the total arsenic in all tissues including bile and urine sampled 24–96 hr postdose.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>535559</pmid><doi>10.1016/0147-6513(79)90029-0</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0147-6513 |
| ispartof | Ecotoxicology and environmental safety, 1979-01, Vol.3 (4), p.394-400 |
| issn | 0147-6513 1090-2414 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74888917 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Arsenic - blood Arsenic - metabolism Arsenic - urine Bile - metabolism Chromatography, Ion Exchange Chromatography, Thin Layer Salmonidae - metabolism Time Factors Tissue Distribution Trout - metabolism |
| title | Metabolism of inorganic arsenic to organoarsenicals in rainbow trout ( Salmo gairdneri) |
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