The use of an Onchocerca volvulus microfilarial antigen skin test in an epidemiological survey of onchocerciasis in Guatemala
Onchocerca volvulus microfilariae obtained from onchocercal nodules were used as antigenic material for a skin test. This antigen is as specific as those previously employed in skin tests, detecting 85·2% of the persons with positive diagnostic signs of onchocerciasis in endemic areas. A low rate of...
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| Veröffentlicht in: | Transactions of the Royal Society of Tropical Medicine and Hygiene 1979, Vol.73 (5), p.543-548 |
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| container_title | Transactions of the Royal Society of Tropical Medicine and Hygiene |
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| creator | Hashiguchi, Yoshihisa Kawabata, Masato Guillermo Zea, F. Manuel Recinos, M.C. Otto Flores, C. |
| description | Onchocerca volvulus microfilariae obtained from onchocercal nodules were used as antigenic material for a skin test. This antigen is as specific as those previously employed in skin tests, detecting 85·2% of the persons with positive diagnostic signs of onchocerciasis in endemic areas. A low rate of false positives was found in the control group in non-endemic areas. The positive rate of reactions in the persons without positive signs in the endemic areas might be due to the presences of cases not detected as a result of palpation for nodules and two skin biopsies. In the examination of the residents of several populations, a close correlation was found between the positive rates of skin tests and the presence of infection. From these findings, we conclude that the skin test using the microfilarial antigen is a suitable procedure for the diagnosis of onchocerciasis. The skin test could also be useful as an epidemiological tool in assessing the effectiveness of control programmes. |
| doi_str_mv | 10.1016/0035-9203(79)90048-8 |
| format | Article |
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This antigen is as specific as those previously employed in skin tests, detecting 85·2% of the persons with positive diagnostic signs of onchocerciasis in endemic areas. A low rate of false positives was found in the control group in non-endemic areas. The positive rate of reactions in the persons without positive signs in the endemic areas might be due to the presences of cases not detected as a result of palpation for nodules and two skin biopsies. In the examination of the residents of several populations, a close correlation was found between the positive rates of skin tests and the presence of infection. From these findings, we conclude that the skin test using the microfilarial antigen is a suitable procedure for the diagnosis of onchocerciasis. The skin test could also be useful as an epidemiological tool in assessing the effectiveness of control programmes.</description><identifier>ISSN: 0035-9203</identifier><identifier>EISSN: 1878-3503</identifier><identifier>DOI: 10.1016/0035-9203(79)90048-8</identifier><identifier>PMID: 531907</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Antigens - isolation & purification ; Child ; Child, Preschool ; Epidemiologic Methods ; Feces - parasitology ; Guatemala ; Humans ; Microfilariae - immunology ; Middle Aged ; Onchocerca - immunology ; Onchocerciasis - diagnosis ; Onchocerciasis - epidemiology ; Skin Tests</subject><ispartof>Transactions of the Royal Society of Tropical Medicine and Hygiene, 1979, Vol.73 (5), p.543-548</ispartof><rights>1979</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c460t-b8493cc1e170262e12e5d76894570402db9dad937636ed2a7f1c48606aaad1253</citedby><cites>FETCH-LOGICAL-c460t-b8493cc1e170262e12e5d76894570402db9dad937636ed2a7f1c48606aaad1253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4021,27921,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/531907$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hashiguchi, Yoshihisa</creatorcontrib><creatorcontrib>Kawabata, Masato</creatorcontrib><creatorcontrib>Guillermo Zea, F.</creatorcontrib><creatorcontrib>Manuel Recinos, M.C.</creatorcontrib><creatorcontrib>Otto Flores, C.</creatorcontrib><title>The use of an Onchocerca volvulus microfilarial antigen skin test in an epidemiological survey of onchocerciasis in Guatemala</title><title>Transactions of the Royal Society of Tropical Medicine and Hygiene</title><addtitle>Trans R Soc Trop Med Hyg</addtitle><description>Onchocerca volvulus microfilariae obtained from onchocercal nodules were used as antigenic material for a skin test. This antigen is as specific as those previously employed in skin tests, detecting 85·2% of the persons with positive diagnostic signs of onchocerciasis in endemic areas. A low rate of false positives was found in the control group in non-endemic areas. The positive rate of reactions in the persons without positive signs in the endemic areas might be due to the presences of cases not detected as a result of palpation for nodules and two skin biopsies. In the examination of the residents of several populations, a close correlation was found between the positive rates of skin tests and the presence of infection. From these findings, we conclude that the skin test using the microfilarial antigen is a suitable procedure for the diagnosis of onchocerciasis. The skin test could also be useful as an epidemiological tool in assessing the effectiveness of control programmes.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Antigens - isolation & purification</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Epidemiologic Methods</subject><subject>Feces - parasitology</subject><subject>Guatemala</subject><subject>Humans</subject><subject>Microfilariae - immunology</subject><subject>Middle Aged</subject><subject>Onchocerca - immunology</subject><subject>Onchocerciasis - diagnosis</subject><subject>Onchocerciasis - epidemiology</subject><subject>Skin Tests</subject><issn>0035-9203</issn><issn>1878-3503</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAQhi3E11L4Bz34hOghYMeOPy5IaClbUKVeFoG4WF570pom8dZOVvTAf8chZY-c5jDP-2rmQeiUkreUUPGOENZUuibsjdRnmhCuKvUIraiSqmINYY_R6og8Ry9y_klI3dBGP0NPG0Y1kSv0e3sDeMqAY4vtgK8GdxMdJGfxIXaHqZsy7oNLsQ2dTcF2BRrDNQw434YBj5BHXGZJwj546EPs4nVwhctTOsD9XBv_dQabQ57xzWRH6G1nX6Inre0yvHqYJ-jrp_Pt-qK6vNp8Xn-4rBwXZKx2imvmHAUqSS1qoDU0XgqleSMJJ7XfaW-9ZlIwAb62sqWOK0GEtdbTumEn6PXSu0_xbipHmz5kB11nB4hTNpIrRRXRBeQLWF7OOUFr9in0Nt0bSsws3cxGzWzUSG3-SjeqxE4f-qddD_4YWiyXdbWsQx7h13Fr060RksnGXHz_YRT_tv6y-bg128K_X3goTg4BkskuwODAhwRuND6G_9_zB9TPoXY</recordid><startdate>1979</startdate><enddate>1979</enddate><creator>Hashiguchi, Yoshihisa</creator><creator>Kawabata, Masato</creator><creator>Guillermo Zea, F.</creator><creator>Manuel Recinos, M.C.</creator><creator>Otto Flores, C.</creator><general>Elsevier Ltd</general><general>Royal Society of Tropical Medicine and Hygiene</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1979</creationdate><title>The use of an Onchocerca volvulus microfilarial antigen skin test in an epidemiological survey of onchocerciasis in Guatemala</title><author>Hashiguchi, Yoshihisa ; Kawabata, Masato ; Guillermo Zea, F. ; Manuel Recinos, M.C. ; Otto Flores, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c460t-b8493cc1e170262e12e5d76894570402db9dad937636ed2a7f1c48606aaad1253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Antigens - isolation & purification</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Epidemiologic Methods</topic><topic>Feces - parasitology</topic><topic>Guatemala</topic><topic>Humans</topic><topic>Microfilariae - immunology</topic><topic>Middle Aged</topic><topic>Onchocerca - immunology</topic><topic>Onchocerciasis - diagnosis</topic><topic>Onchocerciasis - epidemiology</topic><topic>Skin Tests</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hashiguchi, Yoshihisa</creatorcontrib><creatorcontrib>Kawabata, Masato</creatorcontrib><creatorcontrib>Guillermo Zea, F.</creatorcontrib><creatorcontrib>Manuel Recinos, M.C.</creatorcontrib><creatorcontrib>Otto Flores, C.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transactions of the Royal Society of Tropical Medicine and Hygiene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hashiguchi, Yoshihisa</au><au>Kawabata, Masato</au><au>Guillermo Zea, F.</au><au>Manuel Recinos, M.C.</au><au>Otto Flores, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The use of an Onchocerca volvulus microfilarial antigen skin test in an epidemiological survey of onchocerciasis in Guatemala</atitle><jtitle>Transactions of the Royal Society of Tropical Medicine and Hygiene</jtitle><addtitle>Trans R Soc Trop Med Hyg</addtitle><date>1979</date><risdate>1979</risdate><volume>73</volume><issue>5</issue><spage>543</spage><epage>548</epage><pages>543-548</pages><issn>0035-9203</issn><eissn>1878-3503</eissn><abstract>Onchocerca volvulus microfilariae obtained from onchocercal nodules were used as antigenic material for a skin test. This antigen is as specific as those previously employed in skin tests, detecting 85·2% of the persons with positive diagnostic signs of onchocerciasis in endemic areas. A low rate of false positives was found in the control group in non-endemic areas. The positive rate of reactions in the persons without positive signs in the endemic areas might be due to the presences of cases not detected as a result of palpation for nodules and two skin biopsies. In the examination of the residents of several populations, a close correlation was found between the positive rates of skin tests and the presence of infection. From these findings, we conclude that the skin test using the microfilarial antigen is a suitable procedure for the diagnosis of onchocerciasis. The skin test could also be useful as an epidemiological tool in assessing the effectiveness of control programmes.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>531907</pmid><doi>10.1016/0035-9203(79)90048-8</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0035-9203 |
| ispartof | Transactions of the Royal Society of Tropical Medicine and Hygiene, 1979, Vol.73 (5), p.543-548 |
| issn | 0035-9203 1878-3503 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adolescent Adult Aged Antigens - isolation & purification Child Child, Preschool Epidemiologic Methods Feces - parasitology Guatemala Humans Microfilariae - immunology Middle Aged Onchocerca - immunology Onchocerciasis - diagnosis Onchocerciasis - epidemiology Skin Tests |
| title | The use of an Onchocerca volvulus microfilarial antigen skin test in an epidemiological survey of onchocerciasis in Guatemala |
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