Plasma acetate concentrations during canine haemorrhagic shock
Acetate, pyruvate, lactate and NEFA concentrations, as well as acid-base-parameters were followed during bleeding, stable hypotension and re-infusion in five dogs. Mean arterial blood pressures were kept at 30 mmHg during the shock phase. An increase in acetate concentrations (P
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| Veröffentlicht in: | Scandinavian journal of clinical and laboratory investigation 1979-11, Vol.39 (7), p.645-652 |
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| container_title | Scandinavian journal of clinical and laboratory investigation |
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| creator | Kveim, Morten Nesbakken, Ragnar Bredesen, Jan Erik |
| description | Acetate, pyruvate, lactate and NEFA concentrations, as well as acid-base-parameters were followed during bleeding, stable hypotension and re-infusion in five dogs. Mean arterial blood pressures were kept at 30 mmHg during the shock phase. An increase in acetate concentrations (P |
| doi_str_mv | 10.1080/00365517909108869 |
| format | Article |
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Mean arterial blood pressures were kept at 30 mmHg during the shock phase. An increase in acetate concentrations (P<0.01) was found in arterial as well as in venous plasma samples. The maximal mean acetate concentration was 0.19 mmol/1 (during reinfusion) as compared to 0.06 mmol/1 prior to bleeding. There was no difference between arterial and inferior caval venous concentrations. A definite correlation (r = 0.81, P<0.02) was found between blood pyruvate and plasma acetate concentrations. There was no correlation between plasma glucose or NEFA and acetate concentrations or between blood excess lactate and plasma acetate. The plasma acetate accumulation was negligible compared to the concomitant lactate accumulation (1:60), and did not contribute to the metabolic acidosis of shock. The correlation between acetate and pyruvate concentrations may indicate that pyruvate is the main substrate of acetate production in hypovolemic shock.</description><identifier>ISSN: 0036-5513</identifier><identifier>EISSN: 1502-7686</identifier><identifier>DOI: 10.1080/00365517909108869</identifier><identifier>PMID: 43581</identifier><language>eng</language><publisher>England: Informa Healthcare</publisher><subject>acetate ; Acetates - blood ; Acid-Base Equilibrium ; acidosis ; Animals ; Blood Glucose - analysis ; Blood Pressure ; Dogs ; Fatty Acids, Nonesterified - blood ; Female ; Hydrogen-Ion Concentration ; Hypotension, Controlled ; lactate ; Lactates - blood ; Male ; metabolism of shock ; Partial Pressure ; Pyruvates - blood ; Shock, Hemorrhagic - blood ; Time Factors</subject><ispartof>Scandinavian journal of clinical and laboratory investigation, 1979-11, Vol.39 (7), p.645-652</ispartof><rights>1979 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1979</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c314t-3b7eed899643851ca2323ba7ca305d25bacec8184962cf4c2b41e432aa84b9853</citedby><cites>FETCH-LOGICAL-c314t-3b7eed899643851ca2323ba7ca305d25bacec8184962cf4c2b41e432aa84b9853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/00365517909108869$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/00365517909108869$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,59620,59726,60409,60515,61194,61229,61375,61410</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/43581$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kveim, Morten</creatorcontrib><creatorcontrib>Nesbakken, Ragnar</creatorcontrib><creatorcontrib>Bredesen, Jan Erik</creatorcontrib><title>Plasma acetate concentrations during canine haemorrhagic shock</title><title>Scandinavian journal of clinical and laboratory investigation</title><addtitle>Scand J Clin Lab Invest</addtitle><description>Acetate, pyruvate, lactate and NEFA concentrations, as well as acid-base-parameters were followed during bleeding, stable hypotension and re-infusion in five dogs. Mean arterial blood pressures were kept at 30 mmHg during the shock phase. An increase in acetate concentrations (P<0.01) was found in arterial as well as in venous plasma samples. The maximal mean acetate concentration was 0.19 mmol/1 (during reinfusion) as compared to 0.06 mmol/1 prior to bleeding. There was no difference between arterial and inferior caval venous concentrations. A definite correlation (r = 0.81, P<0.02) was found between blood pyruvate and plasma acetate concentrations. There was no correlation between plasma glucose or NEFA and acetate concentrations or between blood excess lactate and plasma acetate. The plasma acetate accumulation was negligible compared to the concomitant lactate accumulation (1:60), and did not contribute to the metabolic acidosis of shock. The correlation between acetate and pyruvate concentrations may indicate that pyruvate is the main substrate of acetate production in hypovolemic shock.</description><subject>acetate</subject><subject>Acetates - blood</subject><subject>Acid-Base Equilibrium</subject><subject>acidosis</subject><subject>Animals</subject><subject>Blood Glucose - analysis</subject><subject>Blood Pressure</subject><subject>Dogs</subject><subject>Fatty Acids, Nonesterified - blood</subject><subject>Female</subject><subject>Hydrogen-Ion Concentration</subject><subject>Hypotension, Controlled</subject><subject>lactate</subject><subject>Lactates - blood</subject><subject>Male</subject><subject>metabolism of shock</subject><subject>Partial Pressure</subject><subject>Pyruvates - blood</subject><subject>Shock, Hemorrhagic - blood</subject><subject>Time Factors</subject><issn>0036-5513</issn><issn>1502-7686</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoO46Lr6A8RLT96qSZO2CYogi1-woAc9h2mabqNtokmK7L-36y6CCJ6G4f2Y4UHomOAzgjk-x5gWeU5KgcW480LsoCnJcZaWBS920XStp6OB7qODEF7xuFPO9tCE0ZyTKbp66iD0kIDSEaJOlLNK2-ghGmdDUg_e2GWiwBqrkxZ077xvYWlUElqn3g7RpIEu6KPtnKGX25vn-X26eLx7mF8vUkUJiymtSq1rLkTBKM-JgoxmtIJSAcV5neXVeF5xwpkoMtUwlVWMaEYzAM4qwXM6Q6eb3nfvPgYdouxNULrrwGo3BFkyXgpO1kayMSrvQvC6ke_e9OBXkmC5Jib_EBszJ9vyoep1_ZP4RjSqlxvV2Mb5Hj6d72oZYdU533iwygRJ_yu_-BVvNXSxVeC1fHWDtyO1f177AuRGiyc</recordid><startdate>197911</startdate><enddate>197911</enddate><creator>Kveim, Morten</creator><creator>Nesbakken, Ragnar</creator><creator>Bredesen, Jan Erik</creator><general>Informa Healthcare</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197911</creationdate><title>Plasma acetate concentrations during canine haemorrhagic shock</title><author>Kveim, Morten ; Nesbakken, Ragnar ; Bredesen, Jan Erik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c314t-3b7eed899643851ca2323ba7ca305d25bacec8184962cf4c2b41e432aa84b9853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>acetate</topic><topic>Acetates - blood</topic><topic>Acid-Base Equilibrium</topic><topic>acidosis</topic><topic>Animals</topic><topic>Blood Glucose - analysis</topic><topic>Blood Pressure</topic><topic>Dogs</topic><topic>Fatty Acids, Nonesterified - blood</topic><topic>Female</topic><topic>Hydrogen-Ion Concentration</topic><topic>Hypotension, Controlled</topic><topic>lactate</topic><topic>Lactates - blood</topic><topic>Male</topic><topic>metabolism of shock</topic><topic>Partial Pressure</topic><topic>Pyruvates - blood</topic><topic>Shock, Hemorrhagic - blood</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kveim, Morten</creatorcontrib><creatorcontrib>Nesbakken, Ragnar</creatorcontrib><creatorcontrib>Bredesen, Jan Erik</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Scandinavian journal of clinical and laboratory investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kveim, Morten</au><au>Nesbakken, Ragnar</au><au>Bredesen, Jan Erik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma acetate concentrations during canine haemorrhagic shock</atitle><jtitle>Scandinavian journal of clinical and laboratory investigation</jtitle><addtitle>Scand J Clin Lab Invest</addtitle><date>1979-11</date><risdate>1979</risdate><volume>39</volume><issue>7</issue><spage>645</spage><epage>652</epage><pages>645-652</pages><issn>0036-5513</issn><eissn>1502-7686</eissn><abstract>Acetate, pyruvate, lactate and NEFA concentrations, as well as acid-base-parameters were followed during bleeding, stable hypotension and re-infusion in five dogs. Mean arterial blood pressures were kept at 30 mmHg during the shock phase. An increase in acetate concentrations (P<0.01) was found in arterial as well as in venous plasma samples. The maximal mean acetate concentration was 0.19 mmol/1 (during reinfusion) as compared to 0.06 mmol/1 prior to bleeding. There was no difference between arterial and inferior caval venous concentrations. A definite correlation (r = 0.81, P<0.02) was found between blood pyruvate and plasma acetate concentrations. There was no correlation between plasma glucose or NEFA and acetate concentrations or between blood excess lactate and plasma acetate. The plasma acetate accumulation was negligible compared to the concomitant lactate accumulation (1:60), and did not contribute to the metabolic acidosis of shock. The correlation between acetate and pyruvate concentrations may indicate that pyruvate is the main substrate of acetate production in hypovolemic shock.</abstract><cop>England</cop><pub>Informa Healthcare</pub><pmid>43581</pmid><doi>10.1080/00365517909108869</doi><tpages>8</tpages></addata></record> |
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| ispartof | Scandinavian journal of clinical and laboratory investigation, 1979-11, Vol.39 (7), p.645-652 |
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| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | acetate Acetates - blood Acid-Base Equilibrium acidosis Animals Blood Glucose - analysis Blood Pressure Dogs Fatty Acids, Nonesterified - blood Female Hydrogen-Ion Concentration Hypotension, Controlled lactate Lactates - blood Male metabolism of shock Partial Pressure Pyruvates - blood Shock, Hemorrhagic - blood Time Factors |
| title | Plasma acetate concentrations during canine haemorrhagic shock |
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