Colony-stimulating Factor and Inhibitor Levels in Acute Granulocytic Leukemia
Assays were performed on bone marrow colony-stimulating-factor (CSF) levels in the serum and urine of 33 patients with acute granulocytic and myelomonocytic leukemia. Of 251 serum samples, 30% showed elevated CSF levels as did 53% of 1422 urines tested. Levels of serum inhibitors of colony formation...
Gespeichert in:
| Veröffentlicht in: | Blood 1971-08, Vol.38 (2), p.143-152 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 152 |
|---|---|
| container_issue | 2 |
| container_start_page | 143 |
| container_title | Blood |
| container_volume | 38 |
| creator | Metcalf, Donald Chan, Soh Ha Gunz, Frederick W. Vincent, Paul Ravich, Robert B.M. |
| description | Assays were performed on bone marrow colony-stimulating-factor (CSF) levels in the serum and urine of 33 patients with acute granulocytic and myelomonocytic leukemia. Of 251 serum samples, 30% showed elevated CSF levels as did 53% of 1422 urines tested. Levels of serum inhibitors of colony formation were abnormally low or undetectable in 57% of sera from leukemic patients. Patients in relapse were unable to respond to infections by developing high serum CSF levels and low serum-inhibitor levels were more common in patients with a short survival time and in some types of patient during relapses. |
| doi_str_mv | 10.1182/blood.V38.2.143.143 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_74875705</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0006497120816188</els_id><sourcerecordid>74875705</sourcerecordid><originalsourceid>FETCH-LOGICAL-c399t-d30f6e29d7a68032d6c71bd70712d15afd527d5db5a08bdabd78671d5441ffaf3</originalsourceid><addsrcrecordid>eNp9kLtOwzAUhi0EKqXwBAgpE1uCL3GcDAxVRUulIhZgtRzbAUNiFzup1LfHoRUjw6-jo_8yfABcI5ghVOK7unVOZW-kzHCGcjLqBEwRxWUKIYanYAohLNK8YugcXITwCWGMYDoBk5ghEBdT8LRwrbP7NPSmG1rRG_ueLIXsnU-EVcnafpjajN9G73QbEmOTuRx6nay8sEPr5L43MprDl-6MuARnjWiDvjreGXhdPrwsHtPN82q9mG9SSaqqTxWBTaFxpZgoSkiwKiRDtWKQIawQFY2imCmqaipgWSsRrbJgSNE8R00jGjIDt4fdrXffgw4970yQum2F1W4InOUlowzSGCSHoPQuBK8bvvWmE37PEeQjRP4LkUeIHPNIZ1Rs3Rznh7rT6q9zpBb9-4Mfieid0Z4HabSVWhmvZc-VM__u_wAG84Rb</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>74875705</pqid></control><display><type>article</type><title>Colony-stimulating Factor and Inhibitor Levels in Acute Granulocytic Leukemia</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Metcalf, Donald ; Chan, Soh Ha ; Gunz, Frederick W. ; Vincent, Paul ; Ravich, Robert B.M.</creator><creatorcontrib>Metcalf, Donald ; Chan, Soh Ha ; Gunz, Frederick W. ; Vincent, Paul ; Ravich, Robert B.M.</creatorcontrib><description>Assays were performed on bone marrow colony-stimulating-factor (CSF) levels in the serum and urine of 33 patients with acute granulocytic and myelomonocytic leukemia. Of 251 serum samples, 30% showed elevated CSF levels as did 53% of 1422 urines tested. Levels of serum inhibitors of colony formation were abnormally low or undetectable in 57% of sera from leukemic patients. Patients in relapse were unable to respond to infections by developing high serum CSF levels and low serum-inhibitor levels were more common in patients with a short survival time and in some types of patient during relapses.</description><identifier>ISSN: 0006-4971</identifier><identifier>EISSN: 1528-0020</identifier><identifier>DOI: 10.1182/blood.V38.2.143.143</identifier><identifier>PMID: 5283026</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Aged ; Animals ; Bone Marrow - growth & development ; Bone Marrow - immunology ; Bone Marrow Cells ; Clone Cells ; Culture Techniques ; Female ; Humans ; Leukemia, Monocytic, Acute - immunology ; Leukemia, Myeloid, Acute - immunology ; Leukocytes - immunology ; Macrophages - immunology ; Male ; Mice ; Middle Aged</subject><ispartof>Blood, 1971-08, Vol.38 (2), p.143-152</ispartof><rights>1971 American Society of Hematology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-d30f6e29d7a68032d6c71bd70712d15afd527d5db5a08bdabd78671d5441ffaf3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27911,27912</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5283026$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Metcalf, Donald</creatorcontrib><creatorcontrib>Chan, Soh Ha</creatorcontrib><creatorcontrib>Gunz, Frederick W.</creatorcontrib><creatorcontrib>Vincent, Paul</creatorcontrib><creatorcontrib>Ravich, Robert B.M.</creatorcontrib><title>Colony-stimulating Factor and Inhibitor Levels in Acute Granulocytic Leukemia</title><title>Blood</title><addtitle>Blood</addtitle><description>Assays were performed on bone marrow colony-stimulating-factor (CSF) levels in the serum and urine of 33 patients with acute granulocytic and myelomonocytic leukemia. Of 251 serum samples, 30% showed elevated CSF levels as did 53% of 1422 urines tested. Levels of serum inhibitors of colony formation were abnormally low or undetectable in 57% of sera from leukemic patients. Patients in relapse were unable to respond to infections by developing high serum CSF levels and low serum-inhibitor levels were more common in patients with a short survival time and in some types of patient during relapses.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Animals</subject><subject>Bone Marrow - growth & development</subject><subject>Bone Marrow - immunology</subject><subject>Bone Marrow Cells</subject><subject>Clone Cells</subject><subject>Culture Techniques</subject><subject>Female</subject><subject>Humans</subject><subject>Leukemia, Monocytic, Acute - immunology</subject><subject>Leukemia, Myeloid, Acute - immunology</subject><subject>Leukocytes - immunology</subject><subject>Macrophages - immunology</subject><subject>Male</subject><subject>Mice</subject><subject>Middle Aged</subject><issn>0006-4971</issn><issn>1528-0020</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1971</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kLtOwzAUhi0EKqXwBAgpE1uCL3GcDAxVRUulIhZgtRzbAUNiFzup1LfHoRUjw6-jo_8yfABcI5ghVOK7unVOZW-kzHCGcjLqBEwRxWUKIYanYAohLNK8YugcXITwCWGMYDoBk5ghEBdT8LRwrbP7NPSmG1rRG_ueLIXsnU-EVcnafpjajN9G73QbEmOTuRx6nay8sEPr5L43MprDl-6MuARnjWiDvjreGXhdPrwsHtPN82q9mG9SSaqqTxWBTaFxpZgoSkiwKiRDtWKQIawQFY2imCmqaipgWSsRrbJgSNE8R00jGjIDt4fdrXffgw4970yQum2F1W4InOUlowzSGCSHoPQuBK8bvvWmE37PEeQjRP4LkUeIHPNIZ1Rs3Rznh7rT6q9zpBb9-4Mfieid0Z4HabSVWhmvZc-VM__u_wAG84Rb</recordid><startdate>197108</startdate><enddate>197108</enddate><creator>Metcalf, Donald</creator><creator>Chan, Soh Ha</creator><creator>Gunz, Frederick W.</creator><creator>Vincent, Paul</creator><creator>Ravich, Robert B.M.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197108</creationdate><title>Colony-stimulating Factor and Inhibitor Levels in Acute Granulocytic Leukemia</title><author>Metcalf, Donald ; Chan, Soh Ha ; Gunz, Frederick W. ; Vincent, Paul ; Ravich, Robert B.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-d30f6e29d7a68032d6c71bd70712d15afd527d5db5a08bdabd78671d5441ffaf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1971</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Animals</topic><topic>Bone Marrow - growth & development</topic><topic>Bone Marrow - immunology</topic><topic>Bone Marrow Cells</topic><topic>Clone Cells</topic><topic>Culture Techniques</topic><topic>Female</topic><topic>Humans</topic><topic>Leukemia, Monocytic, Acute - immunology</topic><topic>Leukemia, Myeloid, Acute - immunology</topic><topic>Leukocytes - immunology</topic><topic>Macrophages - immunology</topic><topic>Male</topic><topic>Mice</topic><topic>Middle Aged</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Metcalf, Donald</creatorcontrib><creatorcontrib>Chan, Soh Ha</creatorcontrib><creatorcontrib>Gunz, Frederick W.</creatorcontrib><creatorcontrib>Vincent, Paul</creatorcontrib><creatorcontrib>Ravich, Robert B.M.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Blood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Metcalf, Donald</au><au>Chan, Soh Ha</au><au>Gunz, Frederick W.</au><au>Vincent, Paul</au><au>Ravich, Robert B.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Colony-stimulating Factor and Inhibitor Levels in Acute Granulocytic Leukemia</atitle><jtitle>Blood</jtitle><addtitle>Blood</addtitle><date>1971-08</date><risdate>1971</risdate><volume>38</volume><issue>2</issue><spage>143</spage><epage>152</epage><pages>143-152</pages><issn>0006-4971</issn><eissn>1528-0020</eissn><abstract>Assays were performed on bone marrow colony-stimulating-factor (CSF) levels in the serum and urine of 33 patients with acute granulocytic and myelomonocytic leukemia. Of 251 serum samples, 30% showed elevated CSF levels as did 53% of 1422 urines tested. Levels of serum inhibitors of colony formation were abnormally low or undetectable in 57% of sera from leukemic patients. Patients in relapse were unable to respond to infections by developing high serum CSF levels and low serum-inhibitor levels were more common in patients with a short survival time and in some types of patient during relapses.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>5283026</pmid><doi>10.1182/blood.V38.2.143.143</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-4971 |
| ispartof | Blood, 1971-08, Vol.38 (2), p.143-152 |
| issn | 0006-4971 1528-0020 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74875705 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adolescent Adult Aged Animals Bone Marrow - growth & development Bone Marrow - immunology Bone Marrow Cells Clone Cells Culture Techniques Female Humans Leukemia, Monocytic, Acute - immunology Leukemia, Myeloid, Acute - immunology Leukocytes - immunology Macrophages - immunology Male Mice Middle Aged |
| title | Colony-stimulating Factor and Inhibitor Levels in Acute Granulocytic Leukemia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T04%3A31%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Colony-stimulating%20Factor%20and%20Inhibitor%20Levels%20in%20Acute%20Granulocytic%20Leukemia&rft.jtitle=Blood&rft.au=Metcalf,%20Donald&rft.date=1971-08&rft.volume=38&rft.issue=2&rft.spage=143&rft.epage=152&rft.pages=143-152&rft.issn=0006-4971&rft.eissn=1528-0020&rft_id=info:doi/10.1182/blood.V38.2.143.143&rft_dat=%3Cproquest_cross%3E74875705%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=74875705&rft_id=info:pmid/5283026&rft_els_id=S0006497120816188&rfr_iscdi=true |