Pretreatment with δ 1-tetrahydrocannabinol and psychoactive drugs: Effects on uptake of biogenic amines and on behavior

Injection of δ 1-tetrahydrocannabinol (THC) into mice increased the uptake into brain synaptosomes of radio-active DA, NE, 5-HT and GABA, with the effect on GABA being the greatest; uptake of leucine was not stimulated, indicating that THC does not facilitate the transport of amino acids in general....

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Veröffentlicht in:	European journal of pharmacology 1979-11, Vol.59 (3), p.267-276
Hauptverfasser:	Hershkowitz, Moshe, Szechtman, Henry
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apomorphine - pharmacology Behavior, Animal - drug effects Biogenic amines Biogenic Amines - metabolism Brain Chemistry - drug effects Dopamine - metabolism Dronabinol - pharmacology gamma-Aminobutyric Acid - metabolism Humans In vivo vitro uptake Leucine - metabolism Male Mice Norepinephrine - metabolism Psychotropic activity Psychotropic Drugs - pharmacology Rats Serotonin - metabolism Stereotyped Behavior - drug effects Stereotyped behaviors THC—receptor interaction δ 1-Tetrahydrocannabinol
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