Fate of Hydralazine in Man. I. Reactions under Gastric Conditions

Tetrazolo [5, 1-α] phthalazine (Tetra-P) was detected by GC and GC-MS in extracts of incubation mixtures of hydralazine (HP) in human saliva with simulated gastric juice (SGJ), while 3-methyl-s-triazolo [3, 4-α] phthalazine (MTP) and s-triazolo [3, 4-α] phthalazine (Tri-P) were identified as the mai...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1979/11/25, Vol.27(11), pp.2820-2826
Hauptverfasser:	NODA, ATSUKO, MATSUYAMA, KENJI, YEN, SHUHWAI, SOGABE, KEIZO, ASO, YOSHINORI, IGUCHI, SADAO, NODA, HIROSHI
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals formation mechanism of Tetra-P Gastric Mucosa - metabolism Humans Hydralazine - metabolism In Vitro Techniques Male Rabbits Saliva - metabolism
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