Biosynthesis of Prostaglandin D2,15-ketoprostaglandin E2, and Hydroxy Fatty Acids by Ram Seminal Vesicle Microsomes

At high arachidonic acid concentrations (164 μM) and without exogenous cofactors, ram seminal vesicle microsomes produced prostaglandin E2 and two less polar products, identified as prostaglandin D2 and 15-ketoprostaglandin E2. The ratio of the biosynthetic products formed depended on the exogenous...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1979-10, Vol.68 (10), p.1302-1306
Hauptverfasser:	Ravikumar, P.R., Pai, J.K., Zmijewski, M.J., Sih, C.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	15-Ketoprostaglandin E2-biosynthesis 15-Ketoprostaglandin E2—biosynthesis, ram seminal vesicles, dependence on arachidonic acid, cofactors Animals arachidonic acid metabolism Arachidonic Acids - metabolism cofactors dependence on arachidonic acid Fatty Acids - biosynthesis In Vitro Techniques Male Microsomes - metabolism Microsomes-seminal vesicles Microsomes—seminal vesicles, prostaglandin synthesis, arachidonic acid metabolism Prostaglandin D2-biosynthesis Prostaglandin D2—biosynthesis, ram seminal vesicle microsomes, dependence on arachidonic acid, cofactors prostaglandin synthesis Prostaglandins - biosynthesis Prostaglandins D - biosynthesis Prostaglandins E - biosynthesis ram seminal vesicle microsomes ram seminal vesicles Seminal Vesicles - metabolism Seminal Vesicles - ultrastructure Seminal vesicles-microsomes Seminal vesicles—microsomes, prostaglandin synthesis, arachidonic acid metabolism Sheep
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