Mode of action of dipyridamole on human platelets

The effects of dipyridamole were investigated on platelet aggregation, ( 14C)-5 hydroxytryptamine release, cyclic nucleotide metabolism and malonyldialdehyde and thromboxane B2 production. Pre-incubation of platelet-rich plasma with dipyridamole inhibited platelet aggregation in response to ADP, epi...

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Veröffentlicht in:	Thrombosis research 1979, Vol.16 (3), p.367-379
Hauptverfasser:	Best, L.C., McGuire, M.B., Jones, P.B.B, Holland, T.K., Martin, T.J., Preston, F.E., Segal, D.S., Russell, R.G.G.
Format:	Artikel
Sprache:	eng
Schlagworte:	3',5'-Cyclic-AMP Phosphodiesterases 3',5'-Cyclic-GMP Phosphodiesterases Adenosine Diphosphate - pharmacology Adenylyl Cyclases - metabolism Blood Platelets - drug effects Cell Membrane - enzymology Cyclic AMP Cyclic GMP Dipyridamole - pharmacology Epinephrine - pharmacology Epoprostenol - pharmacology Humans Malondialdehyde - biosynthesis Platelet Aggregation - drug effects Thromboxane B2 - biosynthesis Time Factors
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