Hexachlorobenzene distribution in tissues of swine
Purified hexachlorobenzene (HCB) was administered to third-litter sows at dietary concentrations of 0, 1, or 20 ppm throughout gestation and nursing. Swine receiving 1 ppm were not adversely affected and residue concentrations in tissues other than fat and bone marrow remained at or below the dietar...
Gespeichert in:
| Veröffentlicht in: | Toxicology and applied pharmacology 1979-01, Vol.51 (1), p.1-7 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 7 |
|---|---|
| container_issue | 1 |
| container_start_page | 1 |
| container_title | Toxicology and applied pharmacology |
| container_volume | 51 |
| creator | Hansen, Larry G. Simon, Joseph Dorn, Steven B. Teske, Richard H. |
| description | Purified hexachlorobenzene (HCB) was administered to third-litter sows at dietary concentrations of 0, 1, or 20 ppm throughout gestation and nursing. Swine receiving 1 ppm were not adversely affected and residue concentrations in tissues other than fat and bone marrow remained at or below the dietary concentration. Residues of HCB in the dissectable fat of these pigs accumulated to concentrations five- to seven-fold higher than the dietary concentration. Piglets accumulated fat residues, through both placental transfer and nursing, that were higher than those of the sows. A similar proportional accumulation of HCB in fat occurred in sows receiving 20 ppm in the diet. Other toxic signs included neutrophilia, gastric irritation, fatty replacement of Brunner's gland, and pancreatic periductal fibrosis. Hepatotoxicity was not apparent, perhaps because of age-related changes in both control and treatment groups. |
| doi_str_mv | 10.1016/0041-008X(79)90002-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_74837525</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0041008X79900024</els_id><sourcerecordid>74837525</sourcerecordid><originalsourceid>FETCH-LOGICAL-c379t-9c51ca7bd685dd78a3cc98414d3b3f0c56d487cc195fef5ba94000d898a32abc3</originalsourceid><addsrcrecordid>eNp9kEtLxDAUhYP4Gkf_wSBdiS6qSZO0zUaQQR1hwIUOuAtpcquRTjMmra9fb8YOLl3dxf3O4fAhNCH4nGCSX2DMSIpx-XRaiDOBMc5StoVGBIs8xZTSbTT6Q_bRQQivkRGMkT20yzNG82yEshl8Kv3SOO8qaL-hhcTY0Hlb9Z11bWLbpLMh9BASVyfhw7ZwiHZq1QQ42twxWtxcP05n6fz-9m56NU81LUSXCs2JVkVl8pIbU5SKai1KRpihFa2x5rlhZaE1EbyGmldKsDjPlCKSmao0HaOToXfl3Vsc0MmlDRqaRrXg-iALVtKCZzyCbAC1dyF4qOXK26XyX5JguTYl1xrkWoMshPw1JVmMTTb9fbUE8xca1MT38fCulZPq2dsgFw9ElBhzznMsInA5ABAlvFvwMmgLrQZjPehOGmf_H_ADT5SA7A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>74837525</pqid></control><display><type>article</type><title>Hexachlorobenzene distribution in tissues of swine</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Hansen, Larry G. ; Simon, Joseph ; Dorn, Steven B. ; Teske, Richard H.</creator><creatorcontrib>Hansen, Larry G. ; Simon, Joseph ; Dorn, Steven B. ; Teske, Richard H.</creatorcontrib><description>Purified hexachlorobenzene (HCB) was administered to third-litter sows at dietary concentrations of 0, 1, or 20 ppm throughout gestation and nursing. Swine receiving 1 ppm were not adversely affected and residue concentrations in tissues other than fat and bone marrow remained at or below the dietary concentration. Residues of HCB in the dissectable fat of these pigs accumulated to concentrations five- to seven-fold higher than the dietary concentration. Piglets accumulated fat residues, through both placental transfer and nursing, that were higher than those of the sows. A similar proportional accumulation of HCB in fat occurred in sows receiving 20 ppm in the diet. Other toxic signs included neutrophilia, gastric irritation, fatty replacement of Brunner's gland, and pancreatic periductal fibrosis. Hepatotoxicity was not apparent, perhaps because of age-related changes in both control and treatment groups.</description><identifier>ISSN: 0041-008X</identifier><identifier>EISSN: 1096-0333</identifier><identifier>DOI: 10.1016/0041-008X(79)90002-4</identifier><identifier>PMID: 524362</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adipose Tissue - metabolism ; Animals ; Body Weight ; Brain - metabolism ; Chlorobenzenes - metabolism ; Diet ; Female ; Hexachlorobenzene - metabolism ; Pregnancy ; Swine ; Tissue Distribution</subject><ispartof>Toxicology and applied pharmacology, 1979-01, Vol.51 (1), p.1-7</ispartof><rights>1979</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c379t-9c51ca7bd685dd78a3cc98414d3b3f0c56d487cc195fef5ba94000d898a32abc3</citedby><cites>FETCH-LOGICAL-c379t-9c51ca7bd685dd78a3cc98414d3b3f0c56d487cc195fef5ba94000d898a32abc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0041-008X(79)90002-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/524362$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hansen, Larry G.</creatorcontrib><creatorcontrib>Simon, Joseph</creatorcontrib><creatorcontrib>Dorn, Steven B.</creatorcontrib><creatorcontrib>Teske, Richard H.</creatorcontrib><title>Hexachlorobenzene distribution in tissues of swine</title><title>Toxicology and applied pharmacology</title><addtitle>Toxicol Appl Pharmacol</addtitle><description>Purified hexachlorobenzene (HCB) was administered to third-litter sows at dietary concentrations of 0, 1, or 20 ppm throughout gestation and nursing. Swine receiving 1 ppm were not adversely affected and residue concentrations in tissues other than fat and bone marrow remained at or below the dietary concentration. Residues of HCB in the dissectable fat of these pigs accumulated to concentrations five- to seven-fold higher than the dietary concentration. Piglets accumulated fat residues, through both placental transfer and nursing, that were higher than those of the sows. A similar proportional accumulation of HCB in fat occurred in sows receiving 20 ppm in the diet. Other toxic signs included neutrophilia, gastric irritation, fatty replacement of Brunner's gland, and pancreatic periductal fibrosis. Hepatotoxicity was not apparent, perhaps because of age-related changes in both control and treatment groups.</description><subject>Adipose Tissue - metabolism</subject><subject>Animals</subject><subject>Body Weight</subject><subject>Brain - metabolism</subject><subject>Chlorobenzenes - metabolism</subject><subject>Diet</subject><subject>Female</subject><subject>Hexachlorobenzene - metabolism</subject><subject>Pregnancy</subject><subject>Swine</subject><subject>Tissue Distribution</subject><issn>0041-008X</issn><issn>1096-0333</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLxDAUhYP4Gkf_wSBdiS6qSZO0zUaQQR1hwIUOuAtpcquRTjMmra9fb8YOLl3dxf3O4fAhNCH4nGCSX2DMSIpx-XRaiDOBMc5StoVGBIs8xZTSbTT6Q_bRQQivkRGMkT20yzNG82yEshl8Kv3SOO8qaL-hhcTY0Hlb9Z11bWLbpLMh9BASVyfhw7ZwiHZq1QQ42twxWtxcP05n6fz-9m56NU81LUSXCs2JVkVl8pIbU5SKai1KRpihFa2x5rlhZaE1EbyGmldKsDjPlCKSmao0HaOToXfl3Vsc0MmlDRqaRrXg-iALVtKCZzyCbAC1dyF4qOXK26XyX5JguTYl1xrkWoMshPw1JVmMTTb9fbUE8xca1MT38fCulZPq2dsgFw9ElBhzznMsInA5ABAlvFvwMmgLrQZjPehOGmf_H_ADT5SA7A</recordid><startdate>19790101</startdate><enddate>19790101</enddate><creator>Hansen, Larry G.</creator><creator>Simon, Joseph</creator><creator>Dorn, Steven B.</creator><creator>Teske, Richard H.</creator><general>Elsevier Inc</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19790101</creationdate><title>Hexachlorobenzene distribution in tissues of swine</title><author>Hansen, Larry G. ; Simon, Joseph ; Dorn, Steven B. ; Teske, Richard H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c379t-9c51ca7bd685dd78a3cc98414d3b3f0c56d487cc195fef5ba94000d898a32abc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Adipose Tissue - metabolism</topic><topic>Animals</topic><topic>Body Weight</topic><topic>Brain - metabolism</topic><topic>Chlorobenzenes - metabolism</topic><topic>Diet</topic><topic>Female</topic><topic>Hexachlorobenzene - metabolism</topic><topic>Pregnancy</topic><topic>Swine</topic><topic>Tissue Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hansen, Larry G.</creatorcontrib><creatorcontrib>Simon, Joseph</creatorcontrib><creatorcontrib>Dorn, Steven B.</creatorcontrib><creatorcontrib>Teske, Richard H.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Toxicology and applied pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hansen, Larry G.</au><au>Simon, Joseph</au><au>Dorn, Steven B.</au><au>Teske, Richard H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hexachlorobenzene distribution in tissues of swine</atitle><jtitle>Toxicology and applied pharmacology</jtitle><addtitle>Toxicol Appl Pharmacol</addtitle><date>1979-01-01</date><risdate>1979</risdate><volume>51</volume><issue>1</issue><spage>1</spage><epage>7</epage><pages>1-7</pages><issn>0041-008X</issn><eissn>1096-0333</eissn><abstract>Purified hexachlorobenzene (HCB) was administered to third-litter sows at dietary concentrations of 0, 1, or 20 ppm throughout gestation and nursing. Swine receiving 1 ppm were not adversely affected and residue concentrations in tissues other than fat and bone marrow remained at or below the dietary concentration. Residues of HCB in the dissectable fat of these pigs accumulated to concentrations five- to seven-fold higher than the dietary concentration. Piglets accumulated fat residues, through both placental transfer and nursing, that were higher than those of the sows. A similar proportional accumulation of HCB in fat occurred in sows receiving 20 ppm in the diet. Other toxic signs included neutrophilia, gastric irritation, fatty replacement of Brunner's gland, and pancreatic periductal fibrosis. Hepatotoxicity was not apparent, perhaps because of age-related changes in both control and treatment groups.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>524362</pmid><doi>10.1016/0041-008X(79)90002-4</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0041-008X |
| ispartof | Toxicology and applied pharmacology, 1979-01, Vol.51 (1), p.1-7 |
| issn | 0041-008X 1096-0333 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74837525 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adipose Tissue - metabolism Animals Body Weight Brain - metabolism Chlorobenzenes - metabolism Diet Female Hexachlorobenzene - metabolism Pregnancy Swine Tissue Distribution |
| title | Hexachlorobenzene distribution in tissues of swine |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T13%3A15%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Hexachlorobenzene%20distribution%20in%20tissues%20of%20swine&rft.jtitle=Toxicology%20and%20applied%20pharmacology&rft.au=Hansen,%20Larry%20G.&rft.date=1979-01-01&rft.volume=51&rft.issue=1&rft.spage=1&rft.epage=7&rft.pages=1-7&rft.issn=0041-008X&rft.eissn=1096-0333&rft_id=info:doi/10.1016/0041-008X(79)90002-4&rft_dat=%3Cproquest_cross%3E74837525%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=74837525&rft_id=info:pmid/524362&rft_els_id=0041008X79900024&rfr_iscdi=true |