Purified human fibroblast interferon in vivo: Skin reactions and effect on bone marrow precursor cells
Human interferon from normal diploid fibroblasts, purified by sequential chromatography on concanavalin A-agarose and phenyl-sepharose, was administered parenterally in 4 subjects. Fever, marked skin hypersensitivity reactions and suppression of marrow stem cells (estimated by the count of myeloid c...
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| Veröffentlicht in: | Cancer letters 1979-09, Vol.7 (5), p.243-249 |
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| container_end_page | 249 |
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| container_issue | 5 |
| container_start_page | 243 |
| container_title | Cancer letters |
| container_volume | 7 |
| creator | Carter, William A. Dolen, Jale G. Leong, Susan S. Horoszewicz, Julius S. Vladutiu, Adrian O. Leibowitz, Alan I. Nolan, James P. |
| description | Human interferon from normal diploid fibroblasts, purified by sequential chromatography on concanavalin A-agarose and phenyl-sepharose, was administered parenterally in 4 subjects. Fever, marked skin hypersensitivity reactions and suppression of marrow stem cells (estimated by the count of myeloid colony-forming cells), side-effects common for less purified fibroblast and leukocyte interferons, were absent. Purified fibroblast interferon retained antiviral and immunomodulatory activity, evidenced by reduction of the blastogenic response of peripheral lymphocytes and decrease of hepatitis B virus markers in a patient with chronic hepatitis B infection treated with this substance. |
| doi_str_mv | 10.1016/S0304-3835(79)80050-6 |
| format | Article |
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Fever, marked skin hypersensitivity reactions and suppression of marrow stem cells (estimated by the count of myeloid colony-forming cells), side-effects common for less purified fibroblast and leukocyte interferons, were absent. Purified fibroblast interferon retained antiviral and immunomodulatory activity, evidenced by reduction of the blastogenic response of peripheral lymphocytes and decrease of hepatitis B virus markers in a patient with chronic hepatitis B infection treated with this substance.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/S0304-3835(79)80050-6</identifier><identifier>PMID: 509407</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Colony-Forming Units Assay ; Fibroblasts - immunology ; Hematopoietic Stem Cells - drug effects ; Hepatitis - drug therapy ; Hepatitis - immunology ; Humans ; Hypersensitivity ; Interferons - pharmacology ; Leukocyte Count ; Lymphocyte Activation - drug effects ; Mitogens - pharmacology ; Skin - drug effects ; Skin - immunology ; Skin Tests</subject><ispartof>Cancer letters, 1979-09, Vol.7 (5), p.243-249</ispartof><rights>1979</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c274t-a0d30a8294dcd908b22e22868cd8fe0a65b572a552a3f0dbd37f64d939aee91d3</citedby><cites>FETCH-LOGICAL-c274t-a0d30a8294dcd908b22e22868cd8fe0a65b572a552a3f0dbd37f64d939aee91d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0304383579800506$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/509407$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carter, William A.</creatorcontrib><creatorcontrib>Dolen, Jale G.</creatorcontrib><creatorcontrib>Leong, Susan S.</creatorcontrib><creatorcontrib>Horoszewicz, Julius S.</creatorcontrib><creatorcontrib>Vladutiu, Adrian O.</creatorcontrib><creatorcontrib>Leibowitz, Alan I.</creatorcontrib><creatorcontrib>Nolan, James P.</creatorcontrib><title>Purified human fibroblast interferon in vivo: Skin reactions and effect on bone marrow precursor cells</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>Human interferon from normal diploid fibroblasts, purified by sequential chromatography on concanavalin A-agarose and phenyl-sepharose, was administered parenterally in 4 subjects. Fever, marked skin hypersensitivity reactions and suppression of marrow stem cells (estimated by the count of myeloid colony-forming cells), side-effects common for less purified fibroblast and leukocyte interferons, were absent. Purified fibroblast interferon retained antiviral and immunomodulatory activity, evidenced by reduction of the blastogenic response of peripheral lymphocytes and decrease of hepatitis B virus markers in a patient with chronic hepatitis B infection treated with this substance.</description><subject>Colony-Forming Units Assay</subject><subject>Fibroblasts - immunology</subject><subject>Hematopoietic Stem Cells - drug effects</subject><subject>Hepatitis - drug therapy</subject><subject>Hepatitis - immunology</subject><subject>Humans</subject><subject>Hypersensitivity</subject><subject>Interferons - pharmacology</subject><subject>Leukocyte Count</subject><subject>Lymphocyte Activation - drug effects</subject><subject>Mitogens - pharmacology</subject><subject>Skin - drug effects</subject><subject>Skin - immunology</subject><subject>Skin Tests</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE9vEzEQxS1UaEPgG7SST6gcFmbt9drupUJV-SNVAilwtrz2WBiSdWrvBvXb12miXjnNSO_NzJsfIRctfGih7T-ugEPXcMXFpdTvFYCApn9BFq2SrJFawQlZPFvOyOtS_kA1dVKcklcCdAdyQcKPOccQ0dPf88aONMQhp2Fty0TjOGEOmNNYW7qLu3RFV39rm9G6KaaxUDt6iiGgm2h1DWlEurE5p390m9HNuaRMHa7X5Q15Gey64NtjXZJfn29_3nxt7r5_-Xbz6a5xTHZTY8FzsIrpzjuvQQ2MIWOqV86rgGB7MQjJrBDM8gB-8FyGvvOaa4uoW8-X5N1h7zan-xnLZDax7BPYEdNcjOwU7_sKZEnEwehyKiVjMNsca_YH04LZ4zVPeM2enZHaPOE1fZ07Px6Yhw3656kDzypfH2SsT-4iZlNcxNGhjxXIZHyK_znwCE65i3k</recordid><startdate>197909</startdate><enddate>197909</enddate><creator>Carter, William A.</creator><creator>Dolen, Jale G.</creator><creator>Leong, Susan S.</creator><creator>Horoszewicz, Julius S.</creator><creator>Vladutiu, Adrian O.</creator><creator>Leibowitz, Alan I.</creator><creator>Nolan, James P.</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197909</creationdate><title>Purified human fibroblast interferon in vivo: Skin reactions and effect on bone marrow precursor cells</title><author>Carter, William A. ; Dolen, Jale G. ; Leong, Susan S. ; Horoszewicz, Julius S. ; Vladutiu, Adrian O. ; Leibowitz, Alan I. ; Nolan, James P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c274t-a0d30a8294dcd908b22e22868cd8fe0a65b572a552a3f0dbd37f64d939aee91d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Colony-Forming Units Assay</topic><topic>Fibroblasts - immunology</topic><topic>Hematopoietic Stem Cells - drug effects</topic><topic>Hepatitis - drug therapy</topic><topic>Hepatitis - immunology</topic><topic>Humans</topic><topic>Hypersensitivity</topic><topic>Interferons - pharmacology</topic><topic>Leukocyte Count</topic><topic>Lymphocyte Activation - drug effects</topic><topic>Mitogens - pharmacology</topic><topic>Skin - drug effects</topic><topic>Skin - immunology</topic><topic>Skin Tests</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carter, William A.</creatorcontrib><creatorcontrib>Dolen, Jale G.</creatorcontrib><creatorcontrib>Leong, Susan S.</creatorcontrib><creatorcontrib>Horoszewicz, Julius S.</creatorcontrib><creatorcontrib>Vladutiu, Adrian O.</creatorcontrib><creatorcontrib>Leibowitz, Alan I.</creatorcontrib><creatorcontrib>Nolan, James P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carter, William A.</au><au>Dolen, Jale G.</au><au>Leong, Susan S.</au><au>Horoszewicz, Julius S.</au><au>Vladutiu, Adrian O.</au><au>Leibowitz, Alan I.</au><au>Nolan, James P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Purified human fibroblast interferon in vivo: Skin reactions and effect on bone marrow precursor cells</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>1979-09</date><risdate>1979</risdate><volume>7</volume><issue>5</issue><spage>243</spage><epage>249</epage><pages>243-249</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><abstract>Human interferon from normal diploid fibroblasts, purified by sequential chromatography on concanavalin A-agarose and phenyl-sepharose, was administered parenterally in 4 subjects. Fever, marked skin hypersensitivity reactions and suppression of marrow stem cells (estimated by the count of myeloid colony-forming cells), side-effects common for less purified fibroblast and leukocyte interferons, were absent. Purified fibroblast interferon retained antiviral and immunomodulatory activity, evidenced by reduction of the blastogenic response of peripheral lymphocytes and decrease of hepatitis B virus markers in a patient with chronic hepatitis B infection treated with this substance.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>509407</pmid><doi>10.1016/S0304-3835(79)80050-6</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3835 |
| ispartof | Cancer letters, 1979-09, Vol.7 (5), p.243-249 |
| issn | 0304-3835 1872-7980 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74836638 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Colony-Forming Units Assay Fibroblasts - immunology Hematopoietic Stem Cells - drug effects Hepatitis - drug therapy Hepatitis - immunology Humans Hypersensitivity Interferons - pharmacology Leukocyte Count Lymphocyte Activation - drug effects Mitogens - pharmacology Skin - drug effects Skin - immunology Skin Tests |
| title | Purified human fibroblast interferon in vivo: Skin reactions and effect on bone marrow precursor cells |
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