Changes in CDP-diglyceride:inositol transferase activity during rabbit lung development
During fetal and neonatal development the specific activity of the enzyme, CDP-diglyceride:inositol transferase in rabbit lung tissue increased 8- to 9-fold from day 17 of gestation to adulthood. This developmental increase in enzyme activity was not specific for lung tissue since a similar increase...
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| Veröffentlicht in: | Pediatric research 1979-10, Vol.13 (10), p.1182-1183 |
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| container_title | Pediatric research |
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| creator | Bleasdale, J E Wallis, P MacDonald, P C Johnston, J M |
| description | During fetal and neonatal development the specific activity of the enzyme, CDP-diglyceride:inositol transferase in rabbit lung tissue increased 8- to 9-fold from day 17 of gestation to adulthood. This developmental increase in enzyme activity was not specific for lung tissue since a similar increase was also observed in liver tissue. The properties of CDP-diglyceride:inositol transferase in microsomes prepared from either fetal or adult rabbit lung tissue appeared to be the same. The increase in CDP-diglyceride:inositol transferase activity in rabbit lung tissue during development appeared to be reflective of synthesis of new enzyme rather than activation of pre-existing enzyme. |
| doi_str_mv | 10.1203/00006450-197910000-00022 |
| format | Article |
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This developmental increase in enzyme activity was not specific for lung tissue since a similar increase was also observed in liver tissue. The properties of CDP-diglyceride:inositol transferase in microsomes prepared from either fetal or adult rabbit lung tissue appeared to be the same. The increase in CDP-diglyceride:inositol transferase activity in rabbit lung tissue during development appeared to be reflective of synthesis of new enzyme rather than activation of pre-existing enzyme.</description><identifier>ISSN: 0031-3998</identifier><identifier>EISSN: 1530-0447</identifier><identifier>DOI: 10.1203/00006450-197910000-00022</identifier><identifier>PMID: 503648</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Animals, Newborn - metabolism ; Cytidine Diphosphate Diglycerides ; Fetus - enzymology ; Liver - enzymology ; Lung - enzymology ; Lung - growth & development ; Phosphotransferases - metabolism ; Rabbits</subject><ispartof>Pediatric research, 1979-10, Vol.13 (10), p.1182-1183</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c291t-8a2aec6a3392697101965562e42843b162680e6ecd8f699614b3a55410f09003</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/503648$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bleasdale, J E</creatorcontrib><creatorcontrib>Wallis, P</creatorcontrib><creatorcontrib>MacDonald, P C</creatorcontrib><creatorcontrib>Johnston, J M</creatorcontrib><title>Changes in CDP-diglyceride:inositol transferase activity during rabbit lung development</title><title>Pediatric research</title><addtitle>Pediatr Res</addtitle><description>During fetal and neonatal development the specific activity of the enzyme, CDP-diglyceride:inositol transferase in rabbit lung tissue increased 8- to 9-fold from day 17 of gestation to adulthood. This developmental increase in enzyme activity was not specific for lung tissue since a similar increase was also observed in liver tissue. The properties of CDP-diglyceride:inositol transferase in microsomes prepared from either fetal or adult rabbit lung tissue appeared to be the same. The increase in CDP-diglyceride:inositol transferase activity in rabbit lung tissue during development appeared to be reflective of synthesis of new enzyme rather than activation of pre-existing enzyme.</description><subject>Animals</subject><subject>Animals, Newborn - metabolism</subject><subject>Cytidine Diphosphate Diglycerides</subject><subject>Fetus - enzymology</subject><subject>Liver - enzymology</subject><subject>Lung - enzymology</subject><subject>Lung - growth & development</subject><subject>Phosphotransferases - metabolism</subject><subject>Rabbits</subject><issn>0031-3998</issn><issn>1530-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtLAzEQx4P4qtVv4CEnb6t5b-JN6hMKeih4DNnd2RrZR02yhX57t7Z2YJj5w39mmB9CmJJbygi_I2MoIUlGTW7oVmVjMnaEJlTyUQiRH6MJIZxm3Bh9ji5i_CaECqnFGTqVhCuhJ-hz9uW6JUTsOzx7_Mgqv2w2JQRfwb3v-uhT3-AUXBdrCC4CdmXya582uBqC75Y4uKLwCTfD2FewhqZftdClS3RSuybC1b5O0eL5aTF7zebvL2-zh3lWMkNTph1zUCrHuWHK5JRQo6RUDATTghdUMaUJKCgrXStjFBUFd1IKSmpixuem6Ga3dhX6nwFisq2PJTSN66Afos2F5lzwfDTqnbEMfYwBarsKvnVhYymxW6L2n6g9ELV_RMfR6_2NoWihOgzuEPJfKmtwQg</recordid><startdate>197910</startdate><enddate>197910</enddate><creator>Bleasdale, J E</creator><creator>Wallis, P</creator><creator>MacDonald, P C</creator><creator>Johnston, J M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197910</creationdate><title>Changes in CDP-diglyceride:inositol transferase activity during rabbit lung development</title><author>Bleasdale, J E ; Wallis, P ; MacDonald, P C ; Johnston, J M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c291t-8a2aec6a3392697101965562e42843b162680e6ecd8f699614b3a55410f09003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Animals</topic><topic>Animals, Newborn - metabolism</topic><topic>Cytidine Diphosphate Diglycerides</topic><topic>Fetus - enzymology</topic><topic>Liver - enzymology</topic><topic>Lung - enzymology</topic><topic>Lung - growth & development</topic><topic>Phosphotransferases - metabolism</topic><topic>Rabbits</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bleasdale, J E</creatorcontrib><creatorcontrib>Wallis, P</creatorcontrib><creatorcontrib>MacDonald, P C</creatorcontrib><creatorcontrib>Johnston, J M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bleasdale, J E</au><au>Wallis, P</au><au>MacDonald, P C</au><au>Johnston, J M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in CDP-diglyceride:inositol transferase activity during rabbit lung development</atitle><jtitle>Pediatric research</jtitle><addtitle>Pediatr Res</addtitle><date>1979-10</date><risdate>1979</risdate><volume>13</volume><issue>10</issue><spage>1182</spage><epage>1183</epage><pages>1182-1183</pages><issn>0031-3998</issn><eissn>1530-0447</eissn><abstract>During fetal and neonatal development the specific activity of the enzyme, CDP-diglyceride:inositol transferase in rabbit lung tissue increased 8- to 9-fold from day 17 of gestation to adulthood. This developmental increase in enzyme activity was not specific for lung tissue since a similar increase was also observed in liver tissue. The properties of CDP-diglyceride:inositol transferase in microsomes prepared from either fetal or adult rabbit lung tissue appeared to be the same. The increase in CDP-diglyceride:inositol transferase activity in rabbit lung tissue during development appeared to be reflective of synthesis of new enzyme rather than activation of pre-existing enzyme.</abstract><cop>United States</cop><pmid>503648</pmid><doi>10.1203/00006450-197910000-00022</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-3998 |
| ispartof | Pediatric research, 1979-10, Vol.13 (10), p.1182-1183 |
| issn | 0031-3998 1530-0447 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74833437 |
| source | MEDLINE; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Animals, Newborn - metabolism Cytidine Diphosphate Diglycerides Fetus - enzymology Liver - enzymology Lung - enzymology Lung - growth & development Phosphotransferases - metabolism Rabbits |
| title | Changes in CDP-diglyceride:inositol transferase activity during rabbit lung development |
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