Somatostatinoma of the duodenum
An adenocarcinoma of the second portion of the duodenum in a ear‐old male is presented. The patient was suffering from pain in the epigastrium. Immunofluorescent studies revealed that it consisted almost exclusively of cells with a distinctly positive somatostatin‐like immunoreactivity. Ultra‐struct...
Gespeichert in:
| Veröffentlicht in: | Cancer 1979-12, Vol.44 (6), p.2273-2279 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2279 |
|---|---|
| container_issue | 6 |
| container_start_page | 2273 |
| container_title | Cancer |
| container_volume | 44 |
| creator | Kaneko, Hiroshi Yanaihara, Noboru Ito, Seiki Kusumoto, Yoshisuke Fujita, Tsuneo Ishikawa, Shinobu Sumida, Toshiko Sekiya, Masao |
| description | An adenocarcinoma of the second portion of the duodenum in a ear‐old male is presented. The patient was suffering from pain in the epigastrium. Immunofluorescent studies revealed that it consisted almost exclusively of cells with a distinctly positive somatostatin‐like immunoreactivity. Ultra‐structurally, the cytoplasm of the tumor cells had numerous large round granules (about 400 μm) with variable electron density. Most of these cells closely resembled the D cells normally seen in the duodenum and the islets of the pancreas, although a few argyrophil cells could be demonstrated by light microscopy. Radioimmunoassay of extracts of the tumor revealed a large amount of somatostatin (2260 pg/mg); substance P and VIP were detected also. Somatostatinoma has been known to occur in the pancreas, but this seems to be the first somatostatinoma found in the intestine. |
| doi_str_mv | 10.1002/1097-0142(197912)44:6<2273::AID-CNCR2820440641>3.0.CO;2-U |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_74831404</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>74831404</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4621-a736c141b300622f1a362f28e2040b816d8554decb9174476128bcefeadb27e3</originalsourceid><addsrcrecordid>eNqVkNtKxEAMhgfxtB7eQHCvRC-6ZjLpTLuKsNTTgrjgAfQq9DDFle1WOy2yb2-XiqAXgldJ-JM_ySfESMJAAuCxhNB4IAkPZWhCiUdEQ32KaNRwOBqfe9FtdIcBAhFokmdqAINocoLe44rofc-uih4ABJ5P6mlTbDn32pYGfbUh1n0IVah7Yv--LOK6dHVcT-dt2i_zfv1i-1lTZnbeFDtiLY9nzu5-xW3xcHnxEF17N5OrcTS68VLSKL3YKJ1KkokC0Ii5jJXGHAPbnghJIHUW-D5lNk1CaYiMlhgkqc1tnCVorNoWB53tW1W-N9bVXExdamezeG7LxrGhQEkCahufu8a0Kp2rbM5v1bSIqwVL4CU6Xr7Py_e5Q8dErHmJjrlFxz_RsWLgaMLIj6333tcRTVLY7Nu5Y9XKWSd_TGd28Z-9f679pahPnGGJDg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>74831404</pqid></control><display><type>article</type><title>Somatostatinoma of the duodenum</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Kaneko, Hiroshi ; Yanaihara, Noboru ; Ito, Seiki ; Kusumoto, Yoshisuke ; Fujita, Tsuneo ; Ishikawa, Shinobu ; Sumida, Toshiko ; Sekiya, Masao</creator><creatorcontrib>Kaneko, Hiroshi ; Yanaihara, Noboru ; Ito, Seiki ; Kusumoto, Yoshisuke ; Fujita, Tsuneo ; Ishikawa, Shinobu ; Sumida, Toshiko ; Sekiya, Masao</creatorcontrib><description>An adenocarcinoma of the second portion of the duodenum in a ear‐old male is presented. The patient was suffering from pain in the epigastrium. Immunofluorescent studies revealed that it consisted almost exclusively of cells with a distinctly positive somatostatin‐like immunoreactivity. Ultra‐structurally, the cytoplasm of the tumor cells had numerous large round granules (about 400 μm) with variable electron density. Most of these cells closely resembled the D cells normally seen in the duodenum and the islets of the pancreas, although a few argyrophil cells could be demonstrated by light microscopy. Radioimmunoassay of extracts of the tumor revealed a large amount of somatostatin (2260 pg/mg); substance P and VIP were detected also. Somatostatinoma has been known to occur in the pancreas, but this seems to be the first somatostatinoma found in the intestine.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/1097-0142(197912)44:6<2273::AID-CNCR2820440641>3.0.CO;2-U</identifier><identifier>PMID: 509396</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adenocarcinoma - metabolism ; Adenocarcinoma - pathology ; Adult ; Cytoplasmic Granules - ultrastructure ; Duodenal Neoplasms - metabolism ; Duodenal Neoplasms - pathology ; Humans ; Male ; Microscopy, Electron ; Somatostatin - biosynthesis ; Substance P - biosynthesis ; Vasoactive Intestinal Peptide - biosynthesis</subject><ispartof>Cancer, 1979-12, Vol.44 (6), p.2273-2279</ispartof><rights>Copyright © 1979 American Cancer Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4621-a736c141b300622f1a362f28e2040b816d8554decb9174476128bcefeadb27e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/509396$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kaneko, Hiroshi</creatorcontrib><creatorcontrib>Yanaihara, Noboru</creatorcontrib><creatorcontrib>Ito, Seiki</creatorcontrib><creatorcontrib>Kusumoto, Yoshisuke</creatorcontrib><creatorcontrib>Fujita, Tsuneo</creatorcontrib><creatorcontrib>Ishikawa, Shinobu</creatorcontrib><creatorcontrib>Sumida, Toshiko</creatorcontrib><creatorcontrib>Sekiya, Masao</creatorcontrib><title>Somatostatinoma of the duodenum</title><title>Cancer</title><addtitle>Cancer</addtitle><description>An adenocarcinoma of the second portion of the duodenum in a ear‐old male is presented. The patient was suffering from pain in the epigastrium. Immunofluorescent studies revealed that it consisted almost exclusively of cells with a distinctly positive somatostatin‐like immunoreactivity. Ultra‐structurally, the cytoplasm of the tumor cells had numerous large round granules (about 400 μm) with variable electron density. Most of these cells closely resembled the D cells normally seen in the duodenum and the islets of the pancreas, although a few argyrophil cells could be demonstrated by light microscopy. Radioimmunoassay of extracts of the tumor revealed a large amount of somatostatin (2260 pg/mg); substance P and VIP were detected also. Somatostatinoma has been known to occur in the pancreas, but this seems to be the first somatostatinoma found in the intestine.</description><subject>Adenocarcinoma - metabolism</subject><subject>Adenocarcinoma - pathology</subject><subject>Adult</subject><subject>Cytoplasmic Granules - ultrastructure</subject><subject>Duodenal Neoplasms - metabolism</subject><subject>Duodenal Neoplasms - pathology</subject><subject>Humans</subject><subject>Male</subject><subject>Microscopy, Electron</subject><subject>Somatostatin - biosynthesis</subject><subject>Substance P - biosynthesis</subject><subject>Vasoactive Intestinal Peptide - biosynthesis</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkNtKxEAMhgfxtB7eQHCvRC-6ZjLpTLuKsNTTgrjgAfQq9DDFle1WOy2yb2-XiqAXgldJ-JM_ySfESMJAAuCxhNB4IAkPZWhCiUdEQ32KaNRwOBqfe9FtdIcBAhFokmdqAINocoLe44rofc-uih4ABJ5P6mlTbDn32pYGfbUh1n0IVah7Yv--LOK6dHVcT-dt2i_zfv1i-1lTZnbeFDtiLY9nzu5-xW3xcHnxEF17N5OrcTS68VLSKL3YKJ1KkokC0Ii5jJXGHAPbnghJIHUW-D5lNk1CaYiMlhgkqc1tnCVorNoWB53tW1W-N9bVXExdamezeG7LxrGhQEkCahufu8a0Kp2rbM5v1bSIqwVL4CU6Xr7Py_e5Q8dErHmJjrlFxz_RsWLgaMLIj6333tcRTVLY7Nu5Y9XKWSd_TGd28Z-9f679pahPnGGJDg</recordid><startdate>197912</startdate><enddate>197912</enddate><creator>Kaneko, Hiroshi</creator><creator>Yanaihara, Noboru</creator><creator>Ito, Seiki</creator><creator>Kusumoto, Yoshisuke</creator><creator>Fujita, Tsuneo</creator><creator>Ishikawa, Shinobu</creator><creator>Sumida, Toshiko</creator><creator>Sekiya, Masao</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197912</creationdate><title>Somatostatinoma of the duodenum</title><author>Kaneko, Hiroshi ; Yanaihara, Noboru ; Ito, Seiki ; Kusumoto, Yoshisuke ; Fujita, Tsuneo ; Ishikawa, Shinobu ; Sumida, Toshiko ; Sekiya, Masao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4621-a736c141b300622f1a362f28e2040b816d8554decb9174476128bcefeadb27e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Adenocarcinoma - metabolism</topic><topic>Adenocarcinoma - pathology</topic><topic>Adult</topic><topic>Cytoplasmic Granules - ultrastructure</topic><topic>Duodenal Neoplasms - metabolism</topic><topic>Duodenal Neoplasms - pathology</topic><topic>Humans</topic><topic>Male</topic><topic>Microscopy, Electron</topic><topic>Somatostatin - biosynthesis</topic><topic>Substance P - biosynthesis</topic><topic>Vasoactive Intestinal Peptide - biosynthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kaneko, Hiroshi</creatorcontrib><creatorcontrib>Yanaihara, Noboru</creatorcontrib><creatorcontrib>Ito, Seiki</creatorcontrib><creatorcontrib>Kusumoto, Yoshisuke</creatorcontrib><creatorcontrib>Fujita, Tsuneo</creatorcontrib><creatorcontrib>Ishikawa, Shinobu</creatorcontrib><creatorcontrib>Sumida, Toshiko</creatorcontrib><creatorcontrib>Sekiya, Masao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kaneko, Hiroshi</au><au>Yanaihara, Noboru</au><au>Ito, Seiki</au><au>Kusumoto, Yoshisuke</au><au>Fujita, Tsuneo</au><au>Ishikawa, Shinobu</au><au>Sumida, Toshiko</au><au>Sekiya, Masao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Somatostatinoma of the duodenum</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>1979-12</date><risdate>1979</risdate><volume>44</volume><issue>6</issue><spage>2273</spage><epage>2279</epage><pages>2273-2279</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><abstract>An adenocarcinoma of the second portion of the duodenum in a ear‐old male is presented. The patient was suffering from pain in the epigastrium. Immunofluorescent studies revealed that it consisted almost exclusively of cells with a distinctly positive somatostatin‐like immunoreactivity. Ultra‐structurally, the cytoplasm of the tumor cells had numerous large round granules (about 400 μm) with variable electron density. Most of these cells closely resembled the D cells normally seen in the duodenum and the islets of the pancreas, although a few argyrophil cells could be demonstrated by light microscopy. Radioimmunoassay of extracts of the tumor revealed a large amount of somatostatin (2260 pg/mg); substance P and VIP were detected also. Somatostatinoma has been known to occur in the pancreas, but this seems to be the first somatostatinoma found in the intestine.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>509396</pmid><doi>10.1002/1097-0142(197912)44:6<2273::AID-CNCR2820440641>3.0.CO;2-U</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0008-543X |
| ispartof | Cancer, 1979-12, Vol.44 (6), p.2273-2279 |
| issn | 0008-543X 1097-0142 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74831404 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adenocarcinoma - metabolism Adenocarcinoma - pathology Adult Cytoplasmic Granules - ultrastructure Duodenal Neoplasms - metabolism Duodenal Neoplasms - pathology Humans Male Microscopy, Electron Somatostatin - biosynthesis Substance P - biosynthesis Vasoactive Intestinal Peptide - biosynthesis |
| title | Somatostatinoma of the duodenum |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T09%3A46%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Somatostatinoma%20of%20the%20duodenum&rft.jtitle=Cancer&rft.au=Kaneko,%20Hiroshi&rft.date=1979-12&rft.volume=44&rft.issue=6&rft.spage=2273&rft.epage=2279&rft.pages=2273-2279&rft.issn=0008-543X&rft.eissn=1097-0142&rft_id=info:doi/10.1002/1097-0142(197912)44:6%3C2273::AID-CNCR2820440641%3E3.0.CO;2-U&rft_dat=%3Cproquest_cross%3E74831404%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=74831404&rft_id=info:pmid/509396&rfr_iscdi=true |