The ecdysteroids from the tobacco hornworm during pupal-adult development five days after peak titer of molting hormone activity
Six naturally occurring C 27 ecdysteroids were isolated and identified from the tobacco hornworm during pupal-adult development five days after peak titer of molting hormone activity. In order of decreasing quantities the hormones were: 20,26-dihydroxyecdysone, 3-epi-20-hydroxyecdysone, 20-hydroxyec...
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| Veröffentlicht in: | Steroids 1979, Vol.34 (3), p.333-345 |
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| creator | Kaplanis, J.N. Thompson, M.J. Dutky, S.R. Robbins, W.E. |
| description | Six naturally occurring C
27 ecdysteroids were isolated and identified from the tobacco hornworm during pupal-adult development five days after peak titer of molting hormone activity. In order of decreasing quantities the hormones were: 20,26-dihydroxyecdysone, 3-epi-20-hydroxyecdysone, 20-hydroxyecdysone, 3-epi-20,26-dihydroxyecdysone, 3-epi-ecdysone, and ecdysone. 20-Hydroxyecdysone, in an earlier study, was the major molting hormone present at peak titer during pupal-adult development. The major ecdysteroid present during embryonic development in this insect, 26-hydroxyecdysone, was not detected. The copresence of all six of these ecdysteroids from a single developmental stage of an insect provides information on the metabolic interrelationships that exist among these steroids and on their possible function(s) in insects. The 3
α-ecdysteroids were far less active than the 3
β-epimers in the house fly assay. The significance of epimerization is discussed. |
| doi_str_mv | 10.1016/0039-128x(79)90084-9 |
| format | Article |
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27 ecdysteroids were isolated and identified from the tobacco hornworm during pupal-adult development five days after peak titer of molting hormone activity. In order of decreasing quantities the hormones were: 20,26-dihydroxyecdysone, 3-epi-20-hydroxyecdysone, 20-hydroxyecdysone, 3-epi-20,26-dihydroxyecdysone, 3-epi-ecdysone, and ecdysone. 20-Hydroxyecdysone, in an earlier study, was the major molting hormone present at peak titer during pupal-adult development. The major ecdysteroid present during embryonic development in this insect, 26-hydroxyecdysone, was not detected. The copresence of all six of these ecdysteroids from a single developmental stage of an insect provides information on the metabolic interrelationships that exist among these steroids and on their possible function(s) in insects. The 3
α-ecdysteroids were far less active than the 3
β-epimers in the house fly assay. The significance of epimerization is discussed.</description><identifier>ISSN: 0039-128X</identifier><identifier>EISSN: 1878-5867</identifier><identifier>DOI: 10.1016/0039-128x(79)90084-9</identifier><identifier>PMID: 494370</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>2 β,14 α,20R22R25-Pentahydroxy-5 β-cholest-7-ene-3,6-dione ; 2 β,14 α,22R,25-Tetrahydroxy-5 β-cholest-7-ene-3,6-dione ; 2 β,3 α,14 α,20R,22R,25-Hexahydroxy-5 β-cholest-7-en-6-one ; 2 β,3 α,14 α,20R22R25,26-Heptahydroxy-50-choiest-7-en-6-one ; 2 β,3 α,14 α,22R,25-Pentahydroxy-5 β-cholest-7-en-6-one ; 2 β,3 β,14 α,20R,22R,25-Hexahydroxy-5 β-cholest-7-en-6-one ; 2 β,3 β,14 α,22R,25,26-Hexahydroxy-5 β-cholest-7-en-6-one ; 2 β,3 β,14 α,22R,25-Pentahydroxy-5 β-cholest-7-en-6-one ; 2 β,3 β,14 α20R,22R,25,26-Heptahydroxy-5 β-cholest-7-en-6-one ; 20,26-Dihydroxyecdysone ; 20-Hydroxyecdysone ; 26-Hydroxyecdysone ; 3-Dehydro-20-hydroxyecdysone ; 3-Dehydroecdysone ; 3-Epi-20,26-dihydroxyecdysone ; 3-Epi-20-hydroxyecdysone ; 3-Epi-ecdysone ; adult insects ; Animals ; Chromatography ; Ecdysone ; Ecdysone - analogs & derivatives ; Ecdysone - isolation & purification ; Ecdysone - metabolism ; ecdysteroids ; epimerization ; epimers ; hormonal regulation ; insect development ; Lepidoptera - growth & development ; Lepidoptera - metabolism ; Magnetic Resonance Spectroscopy ; Manduca sexta ; Pupa - metabolism ; pupae ; pupal development ; stereoisomers</subject><ispartof>Steroids, 1979, Vol.34 (3), p.333-345</ispartof><rights>1979</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c413t-795f4671a1daf50fe4bc767a2a58e56a159b02cb9e1749c9f4910bd8ed9092f73</citedby><cites>FETCH-LOGICAL-c413t-795f4671a1daf50fe4bc767a2a58e56a159b02cb9e1749c9f4910bd8ed9092f73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0039128X79900849$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/494370$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kaplanis, J.N.</creatorcontrib><creatorcontrib>Thompson, M.J.</creatorcontrib><creatorcontrib>Dutky, S.R.</creatorcontrib><creatorcontrib>Robbins, W.E.</creatorcontrib><creatorcontrib>Comissao Reguladora dos Produtos Quimicos e Farmaceuticos, Lisbon (Portugal)</creatorcontrib><title>The ecdysteroids from the tobacco hornworm during pupal-adult development five days after peak titer of molting hormone activity</title><title>Steroids</title><addtitle>Steroids</addtitle><description>Six naturally occurring C
27 ecdysteroids were isolated and identified from the tobacco hornworm during pupal-adult development five days after peak titer of molting hormone activity. In order of decreasing quantities the hormones were: 20,26-dihydroxyecdysone, 3-epi-20-hydroxyecdysone, 20-hydroxyecdysone, 3-epi-20,26-dihydroxyecdysone, 3-epi-ecdysone, and ecdysone. 20-Hydroxyecdysone, in an earlier study, was the major molting hormone present at peak titer during pupal-adult development. The major ecdysteroid present during embryonic development in this insect, 26-hydroxyecdysone, was not detected. The copresence of all six of these ecdysteroids from a single developmental stage of an insect provides information on the metabolic interrelationships that exist among these steroids and on their possible function(s) in insects. The 3
α-ecdysteroids were far less active than the 3
β-epimers in the house fly assay. The significance of epimerization is discussed.</description><subject>2 β,14 α,20R22R25-Pentahydroxy-5 β-cholest-7-ene-3,6-dione</subject><subject>2 β,14 α,22R,25-Tetrahydroxy-5 β-cholest-7-ene-3,6-dione</subject><subject>2 β,3 α,14 α,20R,22R,25-Hexahydroxy-5 β-cholest-7-en-6-one</subject><subject>2 β,3 α,14 α,20R22R25,26-Heptahydroxy-50-choiest-7-en-6-one</subject><subject>2 β,3 α,14 α,22R,25-Pentahydroxy-5 β-cholest-7-en-6-one</subject><subject>2 β,3 β,14 α,20R,22R,25-Hexahydroxy-5 β-cholest-7-en-6-one</subject><subject>2 β,3 β,14 α,22R,25,26-Hexahydroxy-5 β-cholest-7-en-6-one</subject><subject>2 β,3 β,14 α,22R,25-Pentahydroxy-5 β-cholest-7-en-6-one</subject><subject>2 β,3 β,14 α20R,22R,25,26-Heptahydroxy-5 β-cholest-7-en-6-one</subject><subject>20,26-Dihydroxyecdysone</subject><subject>20-Hydroxyecdysone</subject><subject>26-Hydroxyecdysone</subject><subject>3-Dehydro-20-hydroxyecdysone</subject><subject>3-Dehydroecdysone</subject><subject>3-Epi-20,26-dihydroxyecdysone</subject><subject>3-Epi-20-hydroxyecdysone</subject><subject>3-Epi-ecdysone</subject><subject>adult insects</subject><subject>Animals</subject><subject>Chromatography</subject><subject>Ecdysone</subject><subject>Ecdysone - analogs & derivatives</subject><subject>Ecdysone - isolation & purification</subject><subject>Ecdysone - metabolism</subject><subject>ecdysteroids</subject><subject>epimerization</subject><subject>epimers</subject><subject>hormonal regulation</subject><subject>insect development</subject><subject>Lepidoptera - growth & development</subject><subject>Lepidoptera - metabolism</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Manduca sexta</subject><subject>Pupa - metabolism</subject><subject>pupae</subject><subject>pupal development</subject><subject>stereoisomers</subject><issn>0039-128X</issn><issn>1878-5867</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE2L1TAUhoP4db36DwbNatBF9aRNm2YjyOAXDLhwBtyFNDmZibZNTdLr3J0_3daObgQXISHneV8ODyEnDF4yYM0rgEoWrGxvngv5QgK0vJB3yI61oi3qthF3ye4P8uUheZTSVwBoKlk-IPe55JWAHfl5cY0UjT2mjDF4m6iLYaB5-c2h08YEeh3i-CPEgdo5-vGKTvOk-0Lbuc_U4gH7MA04Zur8AanVx0S1W8rohPobzX59BkeH0Oc1vbQNYUSqTfYHn4-PyT2n-4RPbu89uXz39uLsQ3H-6f3HszfnheGsyoWQteONYJpZ7WpwyDsjGqFLXbdYN5rVsoPSdBKZ4NJIxyWDzrZoJcjSiWpPTrfeKYbvM6asBp8M9r0eMcxJCd5CxZazJ3wDTQwpRXRqin7Q8agYqNW7WqWqVaoSUv32ruQSO7ntn7sB7d_QJnoZP9vGTgelr6JP6vJzCayCEmQFslmIp_8STLYM6laUki3A6w3ARdPBY1TJeBwNWh_RZGWD__-KvwAbBqdT</recordid><startdate>1979</startdate><enddate>1979</enddate><creator>Kaplanis, J.N.</creator><creator>Thompson, M.J.</creator><creator>Dutky, S.R.</creator><creator>Robbins, W.E.</creator><general>Elsevier Inc</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1979</creationdate><title>The ecdysteroids from the tobacco hornworm during pupal-adult development five days after peak titer of molting hormone activity</title><author>Kaplanis, J.N. ; Thompson, M.J. ; Dutky, S.R. ; Robbins, W.E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413t-795f4671a1daf50fe4bc767a2a58e56a159b02cb9e1749c9f4910bd8ed9092f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>2 β,14 α,20R22R25-Pentahydroxy-5 β-cholest-7-ene-3,6-dione</topic><topic>2 β,14 α,22R,25-Tetrahydroxy-5 β-cholest-7-ene-3,6-dione</topic><topic>2 β,3 α,14 α,20R,22R,25-Hexahydroxy-5 β-cholest-7-en-6-one</topic><topic>2 β,3 α,14 α,20R22R25,26-Heptahydroxy-50-choiest-7-en-6-one</topic><topic>2 β,3 α,14 α,22R,25-Pentahydroxy-5 β-cholest-7-en-6-one</topic><topic>2 β,3 β,14 α,20R,22R,25-Hexahydroxy-5 β-cholest-7-en-6-one</topic><topic>2 β,3 β,14 α,22R,25,26-Hexahydroxy-5 β-cholest-7-en-6-one</topic><topic>2 β,3 β,14 α,22R,25-Pentahydroxy-5 β-cholest-7-en-6-one</topic><topic>2 β,3 β,14 α20R,22R,25,26-Heptahydroxy-5 β-cholest-7-en-6-one</topic><topic>20,26-Dihydroxyecdysone</topic><topic>20-Hydroxyecdysone</topic><topic>26-Hydroxyecdysone</topic><topic>3-Dehydro-20-hydroxyecdysone</topic><topic>3-Dehydroecdysone</topic><topic>3-Epi-20,26-dihydroxyecdysone</topic><topic>3-Epi-20-hydroxyecdysone</topic><topic>3-Epi-ecdysone</topic><topic>adult insects</topic><topic>Animals</topic><topic>Chromatography</topic><topic>Ecdysone</topic><topic>Ecdysone - analogs & derivatives</topic><topic>Ecdysone - isolation & purification</topic><topic>Ecdysone - metabolism</topic><topic>ecdysteroids</topic><topic>epimerization</topic><topic>epimers</topic><topic>hormonal regulation</topic><topic>insect development</topic><topic>Lepidoptera - growth & development</topic><topic>Lepidoptera - metabolism</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Manduca sexta</topic><topic>Pupa - metabolism</topic><topic>pupae</topic><topic>pupal development</topic><topic>stereoisomers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kaplanis, J.N.</creatorcontrib><creatorcontrib>Thompson, M.J.</creatorcontrib><creatorcontrib>Dutky, S.R.</creatorcontrib><creatorcontrib>Robbins, W.E.</creatorcontrib><creatorcontrib>Comissao Reguladora dos Produtos Quimicos e Farmaceuticos, Lisbon (Portugal)</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Steroids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kaplanis, J.N.</au><au>Thompson, M.J.</au><au>Dutky, S.R.</au><au>Robbins, W.E.</au><aucorp>Comissao Reguladora dos Produtos Quimicos e Farmaceuticos, Lisbon (Portugal)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The ecdysteroids from the tobacco hornworm during pupal-adult development five days after peak titer of molting hormone activity</atitle><jtitle>Steroids</jtitle><addtitle>Steroids</addtitle><date>1979</date><risdate>1979</risdate><volume>34</volume><issue>3</issue><spage>333</spage><epage>345</epage><pages>333-345</pages><issn>0039-128X</issn><eissn>1878-5867</eissn><abstract>Six naturally occurring C
27 ecdysteroids were isolated and identified from the tobacco hornworm during pupal-adult development five days after peak titer of molting hormone activity. In order of decreasing quantities the hormones were: 20,26-dihydroxyecdysone, 3-epi-20-hydroxyecdysone, 20-hydroxyecdysone, 3-epi-20,26-dihydroxyecdysone, 3-epi-ecdysone, and ecdysone. 20-Hydroxyecdysone, in an earlier study, was the major molting hormone present at peak titer during pupal-adult development. The major ecdysteroid present during embryonic development in this insect, 26-hydroxyecdysone, was not detected. The copresence of all six of these ecdysteroids from a single developmental stage of an insect provides information on the metabolic interrelationships that exist among these steroids and on their possible function(s) in insects. The 3
α-ecdysteroids were far less active than the 3
β-epimers in the house fly assay. The significance of epimerization is discussed.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>494370</pmid><doi>10.1016/0039-128x(79)90084-9</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0039-128X |
| ispartof | Steroids, 1979, Vol.34 (3), p.333-345 |
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| recordid | cdi_proquest_miscellaneous_74803180 |
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| subjects | 2 β,14 α,20R22R25-Pentahydroxy-5 β-cholest-7-ene-3,6-dione 2 β,14 α,22R,25-Tetrahydroxy-5 β-cholest-7-ene-3,6-dione 2 β,3 α,14 α,20R,22R,25-Hexahydroxy-5 β-cholest-7-en-6-one 2 β,3 α,14 α,20R22R25,26-Heptahydroxy-50-choiest-7-en-6-one 2 β,3 α,14 α,22R,25-Pentahydroxy-5 β-cholest-7-en-6-one 2 β,3 β,14 α,20R,22R,25-Hexahydroxy-5 β-cholest-7-en-6-one 2 β,3 β,14 α,22R,25,26-Hexahydroxy-5 β-cholest-7-en-6-one 2 β,3 β,14 α,22R,25-Pentahydroxy-5 β-cholest-7-en-6-one 2 β,3 β,14 α20R,22R,25,26-Heptahydroxy-5 β-cholest-7-en-6-one 20,26-Dihydroxyecdysone 20-Hydroxyecdysone 26-Hydroxyecdysone 3-Dehydro-20-hydroxyecdysone 3-Dehydroecdysone 3-Epi-20,26-dihydroxyecdysone 3-Epi-20-hydroxyecdysone 3-Epi-ecdysone adult insects Animals Chromatography Ecdysone Ecdysone - analogs & derivatives Ecdysone - isolation & purification Ecdysone - metabolism ecdysteroids epimerization epimers hormonal regulation insect development Lepidoptera - growth & development Lepidoptera - metabolism Magnetic Resonance Spectroscopy Manduca sexta Pupa - metabolism pupae pupal development stereoisomers |
| title | The ecdysteroids from the tobacco hornworm during pupal-adult development five days after peak titer of molting hormone activity |
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