Prolonged paradoxical effect of aspirin on platelet behaviour and bleeding time in man

A single high dose of aspirin(3.9 g orally) was administered to subjects and the time course of the effects on bleeding time, platelet aggregation and platelet production of thromboxane A 2 was followed over a period of one week. Two hours after treatment the bleeding time remained unchanged althoug...

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Veröffentlicht in:	Thrombosis research 1979, Vol.16 (1), p.69-79
Hauptverfasser:	Amezcua, J.L., O'Grady, J., Salmon, J.A., Moncada, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aspirin - pharmacology Bleeding Time Blood Platelets - drug effects Collagen - pharmacology Dose-Response Relationship, Drug Female Humans Male Partial Thromboplastin Time Platelet Aggregation - drug effects Salicylates - blood Thromboxane A2 - biosynthesis Time Factors
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